CTSAs at five University of California medical campuses (Davis, Irvine, Los Angeles, San Diego and San Francisco) have formed the UC Biomedical Research Acceleration, Integration, and Development (UC BRAID) consortium to enhance UC-wide research collaboration. UC BRAID is streamlining policies and infrastructure in the following key areas:
Go to UC BRAID website
Lead by UCLA’s Dr. Sarah Dry, the UC BRAID Biobanking Initiative was established in order for biobanks to meet emerging federal standards and help accelerate the pace of translational research. It aims to aid in the creation of best practice documentation and a governance model for high-quality biospecimens banks. Through an inclusive governance model and standard processes for “UC-recognized” biobanks, this initiative hopes to ensure biosamples are the highest possible quality and that biobanks are operating ethically and meet professional accredited standards. It also aims to develop biobanking educational programs. Biobanking resources include standard operating procedures for distribution, procurement and storage as well as shared resources on developing efficient and ethical approaches to biobanking research within the UC, governance of biobanks, and outlining best practices for establishing biobanks at UC facilities.
Go to the UC BRAID website to learn more about the biobanking initiative.
Led by UCLA and UCSF CTSIs in 2013, EngageUC was a collaboration that brought together researchers, health care providers, University of California leaders, and community members to develop policies about the management of leftover blood and tissue samples collected for research; redesign the process of asking patient permission for research use of leftover biological samples, including research using genetic information; and create community-guided governance for biobanks across the five University of California medical campuses at Davis, Irvine, Los Angeles, San Diego and San Francisco. It was supported by a $2-million grant from the National Center for Advancing Translational Sciences (NCATS) at NIH.
P-SCANNER, a collaboration of UCLA CTSI; the CTSAs at UC Davis, Irvine, San Diego and San Francisco; the Veteran Health Administration; San Francisco State University; USC and RAND, received a $7-million, 18-month award from the Patient Centered Outcomes Research Institute in December 2013. The project integrated data from three networks covering 21 million patients. UCLA CTSI participated in developing novel methods for distributed analyses that took place without moving patient data to a central location.
A consortium of the five University of California medical campuses at Davis, Irvine, Los Angeles, San Diego and San Francisco has been designated as one of three Centers for Accelerated Innovations by the National Heart, Lung and Blood Institute (NHLBI). The UC Center for Accelerated Innovation (UC CAI) is supported by the CTSAs on each campus. The UC CAI provides entrepreneurship training and up to $200K in funding to advance technologies toward commercialization.
For more information, go to UC CAI website.
The University of California Research eXchange (UC-ReX) is a joint activity of the 5 University of California (UC) CTSAs, charged with fostering multi-site clinical research by providing access to harmonized clinical data from the 5 health systems. The UC-ReX Data Explorer is a secure online system designed to enable UC clinical investigators to identify potential research study cohorts spanning the five UC medical centers. The Data Explorer allows investigators to conduct interactive searches of data derived from patient care activities at Davis, Irvine, Los Angeles, San Diego and San Francisco. Search criteria can include demographics, diagnosis and procedure codes (ICD-9 and CPT), labs, and medications. The output of each query from the UC-ReX Data Explorer is a numeric count of patients by site that match the criteria identified in the query. The numeric count helps investigators assess the feasibility of their study idea by identifying whether there are sufficient numbers of prospective subjects within the UC system.
For more information, go to UC-ReX website.
The California CTSA Education Consortium is comprised of the directors of the training and workforce development programs of California institutions that are presently recipients of Clinical Translational Science Awards (CTSA), and whose intent is to collaborate on common key interests related to education and training in California and the resulting diversity of the populations involved in our research. The collaborating CTSA institutions include Scripps Research Institute, University of Southern California, Stanford University, UC Davis, UC Irvine, UC Los Angeles, UC San Diego, UC San Francisco and Oregon Health and Science University. The Consortium has a common goal of advancing the health of residents of California through our activities and has developed an agenda of shared activities considered to be highly relevant for all of their institutions and also nationally.
Activities underway or in development are:
The UCLA CTSI participates in the Greater Los Angeles Consortium to co-design and develop education and training curricula. There are three CTSA hubs in the Greater Los Angeles CTSA Consortium: University of California, Irvine, University of California, Los Angeles, and University of Southern California. The consortium offers a great opportunity to work together in activities that leverage our local talents and benefit both our local communities and our approaches to clinical research. Our collective goal is to collaborate to develop curricula and online courses that can ultimately be shared with the national consortia online while supporting collaborative efforts across the Greater Los Angeles area through onsite, in-person programs and seminars.
Curricula underway or in development include:
Our hub shares a commitment to improving health in our diverse population with the University of Southern California CTSA. Beginning in 2012 our hubs have collaborated with Los Angeles County on 10 fully partnered team science projects as well as a postdoctoral fellowship training program in mental health. Our hubs have recently broadened this collaboration to form a “research triangle” with Los Angeles County that includes connecting the county’s clinical data warehouse with LADR, which the USC CTSA joined in 2014. LADR, developed and implemented by the UCLA CTSI, will provide unprecedented access to de-identified clinical data and spur both clinical trial accrual and health-services research within the diverse population of Los Angeles. This informatics collaboration also will support projects in the Innovation and Implementation Core.
The UCLA and UMinn CTSIs co-funded three pilot studies in 2013 that address health disparities and health systems problems of importance to Southern California and Minnesota. The awards promote productive, ongoing partnerships between researchers, clinicians and community organizations.
To learn more about these projects, follow this link: http://www.ctsi.ucla.edu/patients-community/pages/research_projects.
The Clinical and Translational Science Award (CTSA) program currently has 62 medical research institutions in 31 states and the District of Columbia. Click here for the list of institutions working together to accelerate discoveries toward better health.
The National Center for Advancing Translational Sciences (NCATS) is one of the 27 institutes and centers (ICs) at the National Institutes of Health (NIH). The mission of NCATS is to transform the translational science process so that new treatments and cures for disease can be delivered to patients faster. NCATS supports the national CTSA program.
CTSA Central is the portal for the national Clinical and Translational Science Awards. It is administered by the CTSA Consortium Coordinating Center at Vanderbilt University. The coordinating center supports collaboration and communication among the CTSAs and provides administrative support for national CTSA committees.