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Funding

CTSI Funding Opportunities & Awardees

For detailed information, open the below tabs.

Catalyst Award

Catalyst Grants support team-building activities that advance translational science and promote collaborations across disciplines and CTSI institutions. Awards range from $100 to $5,000, depending on the nature scope of the project. 2017 application deadlines are April 1, August 1 and December 1. The next application submission period is November 1 - December 1, 2017. Read the RFA and apply here.

Questions? Contact rfp-support@ctrl.ucla.edu

How to Co-fund a Team Science Award

Team Science Awards support, multidisciplinary teams and enable them to obtain preliminary data for extramural grants. They are co-funded by CTSI and other entities (e.g., departments or centers) and issued in amounts ranging from $25,000 to $200,000 for one or two years. They are non-renewable and awarded through competitive, peer-review using an open RFA.

Partnering with CTSI

To initiate the process, a department, center, ORU, etc. must send a letter of intent (LOI) to Dion Baybridge, Director of Research, David Geffen School of Medicine, dbaybridge@mednet.ucla.edu. The programmatic department, institute, center, ORU, etc. must raise and provide matching funds that would be available to all CTSI partner institutes. Faculty are not eligible to apply individually for this LOI as it is intended only for departments, institutes, centers, ORUs, etc. to develop the RFA.

The LOI must include:

  1. the scientific focus of the proposed RFA
  2. an administrative leadership plan
  3. total award and total non-CTSI co-funding (minimum non-CTSI share is 50% of award)

Previous Team Science Awards

CTSI has partnered with departments, centers to develop Team Science RFAs and issue competitive, peer- reviewed, co-funded awards. Examples include:

  • CTSI-UCLA Department of Medicine, Department of Anesthesiology
    • Yibin Wang, “Systems Genetics of Heart Failure: Paving the Road to Translation.”
  • CTSI-UCLA Department of Medicine, Division of Infectious Disease
    • Debika Bhattacharya, “Cardiovascular and Metabolic Complications of HIV and HCV Co-Infection”
  • CTSI-UCLA Department of Human Genetics
    • Steve Horvath, “Diagnostic and Prognostic Biomarkers for HIV-Associated Non-AIDS (HANA) Condition”

Business of Science Venture Team Awards

2016

Principal Investigator PI Institution Project Title
Jau-Nian Chen, Ohyun Kwon UCLA Efsevin: A Novel Small Molecule Suppressor of Cardiac Fibrillation

2012

Principal Investigator PI Institution Project Title
Xiao Hu UCLA TCD-IH: Noninvasive Intracranial Hypertension (IH) Diagnosis

2011

Principal Investigator PI Institution Project Title
Richard Gatti UCLA Development of Small Molecular Readthrough Compounds (SM-RTCs) for Treating Genetic Diseases Involving Nonsense Mutations
Arion Hadjioannou UCLA A System for Vascular Access in Preclinical Models

Catalyst Award

2017

Awardees can be viewed here.              

2016

Awardees can be viewed here.

2015

Awardees can be viewed here.

2014

Awardees can be viewed here.

2013

Awardees can be viewed here.

2012

Awardees can be viewed here.

2011

Awardees can be viewed here.

Core Voucher

2017

Awardees can be viewed here.    

2016

Awardees can be viewed here.

2015

Awardees can be viewed here.

2014

Awardees can be viewed here.

2013

Awardees can be viewed here.

2012

Awardees can be viewed here.

2011

Awardees can be viewed here.

CTRC Seed Grant Awardees

2014

Principal Investigator PI Institution Project Title
Christian Roberts UCLA Effects of Exercise Training on Cardiac Structure and Function in Prediabetes Using 3D Cardiac MRI Technology
Simon Beaven UCLA Development of a novel biomarker for liver fibrosis
Sahib Khalsa UCLA A new anxiety treatment through augmented interoceptive exposure training
Jennie Tsao
Kirsten Tillisch
UCLA Brain connectivity and structure pain inhibition and gut microbiota in pediatric irritable bowel syndrome

2013

Principal Investigator PI Institution Project Title
Erik Dutson UCLA Brain Responses Associated with Ingestive Behavior in Obese Patients: The Effects of Bariatric Surgery, and their Association with Behavioral and Satiety Signal Responses
Albert Shieh UCLA The Effects of Vitamin D3 versus 25OHD3 Supplementation on Serum Vitamin D Metabolites and Markers of Mineral Metabolism and Immune Function
Kattayoun Kordy UCLA Dose-Response Relationship of Tenofovir with HIV-1 Suppression in Ex-Vivo Model of Tissue Infectibility in Adolescents
Lara Ray
UCLA Repositioning Ivermectin for the Treatment of Alcohol Use Disorders
Murray Kwon
UCLA Mechanism of B-cell Activation and Hyperreactivity-Induced Sensitization Post Mechanical Circulatory Support Device Insertion
Aleksey Matveyenko UCLA Does Reversal of Melatonin Deficiency in Patients with Type 2 Diabetes Lead to Preservation of Insulin Secretion and Glucose Control?

CTSI / UCLA David Geffen School of Medicine Team Science - Additional Topics (Mental Illness)

2017

Principal Investigator PI Institution Project Title
Philippe Bourgois, Joel Braslow UCLA Integrating Policy and Research on Homelessness, Incarceration and Severe Mental Illness

CTSI / UCLA David Geffen School of Medicine Team Science - Cancer Theme

2017

Principal Investigator PI Institution Project Title
Roshan Bastani UCLA Liver Cancer Prevention and Control - Understanding and Addressing Disparities
Harvey Herschman UCLA A New Therapeutic Approach for Multiple Myeloma, Based on a Unique Biochemical Feature

CTSI / UCLA David Geffen School of Medicine Team Science - Cardiovascular Theme

2017

Principal Investigator PI Institution Project Title
Huan Meng UCLA Development of CRISPR/Cas9 Nanotherapeutics to Treat Cardiac Dysfunction in Duchenne Muscular Dystrophy
Susanne Nicholas UCLA Investigation of the effect of chronic kidney disease on the development of atherosclerosis and vascular calcification

CTSI / UCLA David Geffen School of Medicine Team Science - Immunity, Inflammation, Infection, and Transplantation Theme

2017

Principal Investigator PI Institution Project Title
Samuel Weigt UCLA Using X-ray-based Functional Lung Imaging Technology to Detect Lung Allograft Dysfunction
Dimitrios Iliopoulis UCLA Development and effectiveness of HDAC9-specific pharmacological inhibitors to suppress the inflammatory response in Inflammatory Bowel Diseases
Airie Kim UCLA The Role of Zip8 in Host Defense Against Pulmonary Infection
Caroline Kuo UCLA Gene Correction of X-Linked Agammaglobulinemia Using Targeted Endonucleases
Elizabeta Nemeth UCLA The mechanism of adverse interaction between iron and inflammation in pregnancy
Dinesh Rao UCLA The role of the RNA binding protein, IGF2BP3, in B-cell activation

CTSI / UCLA David Geffen School of Medicine Team Science - Metabolism Theme

2017

Principal Investigator PI Institution Project Title
David Nathanson UCLA Integrated metabolic and molecular profiling of malignant gliomas

CTSI / UCLA David Geffen School of Medicine Team Science - Neuroscience Theme

2017

Principal Investigator PI Institution Project Title
Alcino Silva UCLA Molecular, cellular, and circuit mechanisms of the role of memory linking in causal reasoning
Josh Trachtenberg UCLA Dissecting the Neuronal Microcircuits of Decision-Making Using 2 Photon Ca++ Imaging
Neil Harris UCLA The role of astrocyte network function in concussive brain injury
Melissa Spencer UCLA Investigation of a Non-canonical WNT Activator that Increases Muscle Growth

CTSI / UCLA David Geffen School of Medicine Team Science - Regenerative Medicine Theme

2017

Principal Investigator PI Institution Project Title
Amander Clark UCLA Regenerating germline cells from pluripotent stem cells
Brigitte Gomperts UCLA Using a 4-D stretchable scaffold to identify new therapies for lung fibrosis
Leanne Jones UCLA Assessing intestinal stem cell aging utilizing the epigenetic clock
Hanna Mikkola UCLA Transcription elongation as a regulator of human HSC stemness
Paul Weiss UCLA High-Throughput Vector-Free Delivery of Gene-Editing Payloads via Rapid Mechanical Deformation Enabled by Omniphobic Microfluidic Systems

Iris Cantor Women's Health Center / CTSI - Augmentation Awards

2015

Principal Investigator PI Institution Project Title
Edythe London,
Nicole Peterson
UCLA Sex/gender differences in the neural and behavioral response to reduced nicotine cigarettes
Kirsten Tillisch UCLA Sex differences in gut microbiota-gut brain axis
Madhuri Wadehra UCLA Determination of EMP2 antibody drug conjugates for treatment of triple negative breast cancer

Iris Cantor Women's Health Center / CTSI - Cervical Cancer Awards

2016

Principal Investigator PI Institution Project Title
Adriana Vidal
Cedars-Sinai
Increasing human papilloma virus vaccine uptake via general health messaging
Otto Yang
UCLA Novel therapeutic vaccine that elicits cellular immunity to clear human papilloma virus (HPV) infection

Iris Cantor Women's Health Center / CTSI - Pilot Awards

2017

Principal Investigator PI Institution Project Title
Margaret Mohr, Paul Micevych UCLA Hypothalamic astrocyte proliferation: Role in female reproduction (Puberty)
Kurt Zeyneb, Xia Yang UCLA Understanding sexual dimorphism of non-alcoholic fatty liver disease via big data integration
Elizabeth Evans, Alison Hamilton U.S. Department of Veterans Affairs, UCLA A mixed methods approach to understanding gender differences in pain and behavioral responses to complementary and integrative health (CIH/CAM) in military veterans
Stephanie Correa UCLA A female specific brain-bone axis: Investigating bone regulating neurons in the hypothalamus
Amander Clark UCLA Exploring the use of stem cells to overcome infertility after cancer therapy

2016

Principal Investigator PI Institution Project Title
Otto Yang, Anna Barbara Moscicki UCLA Novel Therapeutic Vaccine that Elicits Cellular Immunity to Clear Human Papilloma Virus (HPV) Infection
Adriana Vidal, Peter Szilagyi UCLA Increasing Human Papilloma Virus Vaccine Uptake via General Health Massaging

2015

Principal Investigator PI Institution Project Title
Hillary Coller UCLA Is switching from long to short form RECK an important contributor to breast cancer progression and metastasis for triple negative breast cancer?
Mansoureh Eghbali UCLA The estrogen paradox and the role of micro-RNA-193 I the rescue action of phytoestrogen genistein in pulmonary hypertension
Mark Goodarzi Cedars-Sinai A systems genetics investigation of adipose tissue dysfunction in the pathogenesis of polycystic ovary syndrome
Sandra Orsulic Cedars-Sinai Collagen remodeling during ovarian aging
Kathrin Plath
Anna Sahakyan
UCLA CRISPR/Cas9 screen for the establishment of human naïve pluripotent stem cell culture conditions
Claudia SanMiguel,
Emeran Mayer
UCLA Brain activity associated with hunger and satiation and in response to food-cues in obese women, and its relation to weight loss after bariatric surgery
Mary Sehl UCLA Studying age accelerating effects in breast tissue and their relationship to breast cancer risk: How methylation patterns in female breast change with hormone exposure

Iris Cantor Women's Health Center / CTSI - Young Investigator Awards

2013

Principal Investigator PI Institution Project Title
Alexandra Dupont,
Julienne Bower
UCLA Early life influences on adulthood health: exploring the association in breast cancer survivors and young adults
Zhenqi Zhou,
Andrea Hevener
UCLA Impact of skeletal muscle Lmcd1 expression on Era action in the maintenance of metabolic homeostatsis

Junior Faculty Mentored-Research Award

2013

Principal Investigator PI Institution Project Title
Alan Chiem Olive View Point-of-Care Echocardiography and Pulmonary Ultrasound to Identify, Manage, and Risk-Stratify Patients with Acute Heart Failure Syndrome Presenting to the Emergency Department
Breena Taira UCLA Determinants of Pediatric Scald Risk in the Latino community: A Foundation for the Development of Evidence-based Community Scald Prevention Initiatives
Anna Milanesi UCLA/VA Greater Los Angeles Healthcare System Thyroid hormone receptor isoforms specificity in skeletal muscle differentiation and regeneration
Florian Rader Cedars-Sinai Default Medication Intensification to Overcome Physician Inertia in the Treatment of Hypertension
Vivian Chang UCLA Exome Sequencing of Pediatric Patients with Cancer Predisposition
Ted Hutman UCLA Visual Scan Patterns in Response to Self- and Other-Modeled Emotion in Children with Autism Spectrum Disorders
Eduard Panosyan LA BioMed Use of Enzymatic Depletion of Amino Acids to Enhance the Effect of Cytotoxic Chemotherapy Against Brain Tumors
Satiro de Oliveira UCLA Anti-leukemic Immunotherapy Using Modification of Hematopoietic Stem Cells
Stephen Shiao Cedars-Sinai Effects of Chemotherapy and Radiation on Intestinal Inflammation and Microbiota
Alice Chung Cedars-Sinai The effect of basal gene expression on prognosis and Herceptin resistance in operable Her2+ invasive breast cancer
Mitchell Kamrava UCLA Molecular and multiparametric-MRI image profiling of sensitivity to neoadjuvant androgen deprivation therapy (ADT) during definitive radiation treatment for high risk prostate cancer

2012

Principal Investigator PI Institution Project Title
Chrisandra Shufelt Cedars-Sinai Estrogen Deficiency and Cardiovascular Disease in Premenopausal Women
Heather Jones Cedars-Sinai Acute Lung Injury and Effects of NAMPT and NAM in Modulating Lung Inflammation
Bahman Chavoshan UCLA The role of neuronal nitric oxide synthase (nNOS) in the pathophysiology of COPD skeletal muscle dysfunction
Anuja Shah UCLA Metabolic Effect of Different Sources of Dietary Phosphorus
James Byrne UCLA Investigating the Potential of Reprogrammed Pluripotent Stem Cells for Patien-Specific Cellular Immunophenotyping to Differentiate Infection from Rejecting in Inestinal Transplantation
Laura Wozniak UCLA Immunophenotyping to Differentiate Infection from Rejection in Intestinal Transplantation
Elizabeth Bromley UCLA Intervention for Individuals with Severe Mental Illness
Denis Evseenko UCLA Inhibition of the lysophoshatidic acid signaling as a novel strategy for restoration of posttraumatic cartilage
Edward Lee UCLA Potential application of Irreversible Electroporation (IRE) in the treatment of pancreatic cancer
Yoon-Hee Cha UCLA Functional Neuroimaging and Neuromodulation in Mal de Debarquement Syndrome
Paul Tumeh UCLA A Needle-Free Nanovaccine Against Melanoma
Thao Nguyen UCLA Fibrosis, Stress, and Ventricular Arrhythmias

Multi-CTSI Team Science - (UCLA/University of Minnesota) Cross-Institutional Award

2012

UM Scholar UCLA Scholar Project Title
Josheph E. Gaugler Joshua Chodosh Alzheimer's Disease Coordinated Care for Hispanic and Latino Seniors
William Riley Hector Rodriguez HIE Use in Small- and Medium-Sized Primary Care Practices: Understanding & Eliminating the Disparity
Robert Simon Jones Francisco J. Ramos-Gomez Correlation of Early Childhood Caries Risk and Obesity in Preschool Age Children Via Salivary Testing

Multi-CTSI Team Science - (UCLA and USC/CHLA) Healthy Aging in Los Angeles Team Science Award

2014

Principal
Investigator
PI Institution Project Title
Catherine
Sarkisian
UCLA Process and Impact Evaluation of the Healthy Communities LA! - A Community Chronic Disease Self-Management Program for Older Adults in Los Angeles County
William Vega USC The Los Angeles Healthy Aging Indicator Project
Maria Aranda USC Bringing Evidenced-Based Depression Treatment to Historically Underrepresented Older Minorities
Arleen Brown UCLA The Use of Evidence-based Aging Initiatives in LA County and Developing Community-Informed Metrics of their Effectiveness
Steven Wallace UCLA Assessing Community Needs and Capacity to Increase the Use of Clinical Preventive Services by Underserved Adults Ages 50 Years and Older in South Los Angeles

Older Americans Independence Center (OAIC) and CTSI Career Development Award (CDA)

2016

Principal Investigator PI Institution Project Title
Joanna Schaenman UCLA Evaluation of T Cell Immune Function Impairment in Elderly Solid Organ Transplant Recipients (year 3)

2015

Principal Investigator PI Institution Project Title
Joseph Dzierzewski UCLA/VA Greater Los Angeles Healthcare System Cognitive Response to Improved Sleep in Late-Life: the Role of Inflammation (year 3)
Lee Jennings UCLA Evaluation of a Comprehensive Dementia Care Program: Quality, Health Outcomes, Cost and Utilization (year 3)
Joanna Schaenman UCLA Evaluation of T Cell Immune Function Impairment in Elderly Solid Organ Transplant Recipients (year 2)

2014

Principal Investigator PI Institution Project Title
Joseph Dzierzewski UCLA/VA Greater Los Angeles Healthcare System Cognitive Response to Improved Sleep in Late-Life: the Role of Inflammation (year 2)
Lee Jennings UCLA The UCLA Alzheimer's and Dimentia Care Program: A Comprehensive, Coordinated, Patient-Centered Care for an Incurable Disorder (year 2)
Joanna Schaenman UCLA Evaluation of T Cell Immune Function Impairment in Elderly Solid Organ Transplant Recipients (year 1)

2013

Principal Investigator PI Institution Project Title
Joseph Dzierzewski UCLA/VA Greater Los Angeles Healthcare System Cognitive Response to Improved Sleep in Late-Life: the Role of Inflammation (year 1)
Lee Jennings UCLA The UCLA Alzheimer's and Dimentia Care Program: A Comprehensive, Coordinated, Patient-Centered Care for an Incurable Disorder (year 1)
Jordan Lake UCLA Addressing Chronic Inflammation and Comorbidity in HIV-infected Aging Adults (year 1)

Older Americans Independence Center (OAIC) and CTSI Rapid Grants Program

2015

Principal Investigator PI Institution Project Title
Ramesh Halder UCLA Impact of Aging on Hydrocarbon Oil-induced Pulmonary Vascular Inflammation and Alveolar Hemorrhage
Theodore Kelesidis UCLA Ex Vivo/In Vitro Studies of Novel Therapeutics for HIV-Related Accelerated Aging
Zhenqi Zhou UCLA The Role of DJ1 in Regulating Metabolic Homeostasis, Adiposity, and Inflammation with Aging

2014

Principal Investigator PI Institution Project Title
Pritha Gupta UCLA Soluble CD200 may Positively Correlate with Age and CAD Severity
Sangeeta Dhawan UCLA Promoting Beta Cell Regeneration in Aging with Growth Factor GDF11
Vera Chesnokova Cedars-Sinai Gro1 Promotes Senescence of Hippocampal Neural Progenitors in Aging Brain
Miklos Peterfy Cedars-Sinai Hematopoietic Rejuvenation as a Therapeutic Approach in Aging Associated Inflammation and Metabolic Dysfunction
Homero E. del Pino Charles R. Drew University Evaluating the Usability of an Alcohol SBI (CARET-HIV) for Older Adults with HIV Infection
Ram Singh UCLA Changes in Non-conventional T-cells that Reach Against Lipids with Aging: Role in Inflammation and Immune Suppression
Theodore Robles UCLA Social Engagement and Health in Assisted Living Facilities

2013

Principal Investigator PI Institution Project Title
Pia Banerjee UCLA Neurocognitive, Functional, and Neuroimaging Predictors of Radiation-Induced Neurocognitive Decline in Elderly Malignan Glioma Patients
Albert Shieh UCLA Assessing the Balance Between Bone Formation and Resorption: An Index of Net Bone Formation
Christian Roberts UCLA Characterization of Myocellular Lipids in Older Obese Adults Using Novel MR Spectroscopic Imaging
Joanna Schaenman UCLA Immunologic Control of Infection in the Elderly Kidney Transplant Recipient
Jonathan Wanagat UCLA Characterization of Myocellular Lipids in Older Obese Adults Using Novel MR Spectroscopic Imaging
David Casero UCLA Identification of Protective Factors for the Regenerative Recovery of Immune System Function: the Molecular Signatures of Murine and Human Thymic Aging

2012

Principal Investigator PI Institution Project Title
Meredith Braskie UCLA Growth Factors, Neuroinflammation, Exercise, and Brain Integrity
David Black UCLA RCT of Mindful Awareness Practices for Sleep and inflammation in Older Adults
Marissa Caudill UCLA RCT of Mindful Awareness Practices for Sleep and inflammation in Older Adults
Gelareh Gabayan UCLA Emergency Department Crowding and Community Determinants and Patient Outcomes
Donald Lamkin UCLA Stress-Induced Inflammatory Signaling in Leukemia
Lee Jennings UCLA Perspectives of Persons Aging with HIV
Eric Hayden UCLA Structural Determination of Aβ40 and Aβ42 Oligomers of Specific Size (Order)

Pathfinder Awards

2015

Principal Investigator PI Institution Project Title
William Hsu UCLA Building Research Maps for Catalyzing Translational Medicine
Susanne Nicholas UCLA Validation of a Clinical Biomarker and a Novel Point-of-Care Device for Diabetic Kidney Disease
Aydogan Ozcan UCLA Dual-Color Mobile Phone-based Fluorescence Microscopy Platform for the Detection of IS6110 Insertion Fragment in Mycobacterium Tuberculosis DNA 
Sean Young UCLA An Automated Platform for Mining Social Data and Predicting Behaviors

Team Science - Basic and Clinical Approaches to HIV/AIDS

2015

Principal Investigator PI Institution Project Title
Dimitrios Vatakis UCLA Digital genomic quantification of CD8 T-Cell subset clonality in HIV infection
Matthew Marsden UCLA Evaluating HIV latency and persistence in vivo using genetically barcoded

2013

Principal Investigator PI Institution Project Title
Debika Bhattacharya UCLA Cardiovascular and Metabolic Complications of HIV/HCV Co-infection
Irvin Chen UCLA Genetic engineering of a multifactorial approach to cure AIDS
Genhong Cheng UCLA 25-Hydroxycholesterol and its analogs as novel broad antiviral agents
David Gere UCLA Mixed methods secondary data analysis for AMP!
Risa Hoffman UCLA Understanding retention in Malawi's Option B+ Program
Ian Holloway UCLA Network influences on HIV risk and technology use among Dominican MSM sex workers
Steve Horvath UCLA Diagnostic and prognostic biomarkers for HIV-Associated Non-AIDS (HANA) condition
Sung-Jae Lee UCLA Enhancing linkage to care for MSM through provider-outreach worker paired teams
Anne Rimoin UCLA Understanding the Relationship between HIV and Schistosomaisis in the Congo Basin

2012

Principal Investigator PI Institution Project Title
Genhong Cheng UCLA 25-Hydroxycholesterol and its analogs as novel broad antiviral agents
Steve Horvath UCLA Diagnostic and prognostic biomarkers for HIV-Associated Non-AIDS (HANA) condition
Debika Bhattacharya UCLA Cardiovascular and Metabolic Complications of HIV/HCV Co-infection
Irvin Chen UCLA Genetic engineering of a multifactorial approach to cure AIDS

Team Science - Cardiac Fibrosis: Basic Biology and Translation to Human Heart Disease

2015

Principal Investigator PI Institution Project Title
Arjun Deb UCLA
Understanding heart fibrosis: from genetics to imaging and therapy

Team Science - Cardiovascular Theme Team Science

2015

Principal Investigator PI Institution Project Title
Thomas Vondriska UCLA Epigenomic diagnosis and treatment of cardiovascular disease
Mansoureh Eghbali UCLA Role of oxidized lipids and miR193 in pulmonary hypertension

2012

Principal Investigator PI Institution Project Title
Yibin Wang
Jake Lusis
UCLA Systems Genetics of Heart Failure: Paving the Road to Translation

Team Science - Center for Duchenne Muscular Dystrophy

2015

Principal Investigator PI Institution Project Title
Daniel Ennis UCLA Measuring cardiomyocyte performance in vivo with MRI
Huan Meng UCLA Custom design of polyrotaxane nanocarrier for CRISPR/Cas9 delivery in DMD
Stan Nelson UCLA Assessment of vacuum needle biopsy system for sampling in muscle disease
Frank Petrigliano UCLA (not available)
Melissa Spencer UCLA Generation of a humanzed mouse model of DMD

2014

Principal Investigator PI Institution Project Title
Karen Reue,
Andrea Hevener
UCLA Genetic and molecular determinants of statin related myopathy in the mouse
Bridgitte Gomperts,
April Pyle
UCLA Improving our understanding of Duchenne Muscular Dystrophy by modeling the muslce niche
Rachelle Crosbie-Watson,
Ken Roos
UCLA Restoration of muscle cell adhesion to treat cardiomyopathy in muscular dystrophy
M. Carrie Miceli,
Stanley Nelson,
April Pyle,
Rachelle Crosbie-Watson,
Melissa Spencer,
Linda Baum
UCLA Stem cell approaches for combination DMD Exon skipping therapy

Team Science - Children's Discovery and Innovation Institute (CDI) and CTSI Children’s Health

2015

Principal Investigator Project Title
Isidro Salusky Roles of iron, phosphate, and chronic kidney disease in the regulation of fibroblast growth factor 23
Rashmi Shetgiri A primary care-based, family-focused intervention to reduce Latino youth violence

2014

Principal Investigator Project Title
Donald Kohn Stem cell gene therapy for sickle cell disease
Joanna Jen Improving the Diagnosis and Treatment of Enigmatic Pediatric Neurological Disorders
Sheryl Katoaka Redesigning depression detection and treatment for low-income minority adolescents in school health clinic
Harley Kornblum Neural stem cells in autism pathophysiology
Biagio Saitta Patient-Derived Induced Pluripotent Stem Cells and Mouse Models to Identify Regulatory Mechanisms of Skeletal Dysplasias

Team Science - Immunity, Inflammation, Infection and Transplantation (I3T)

2014

Principal Investigator PI Institution Project Title
Dino Di Carlo,
Jeffrey Zink
UCLA Magnetic-nanoparticle induced mechanical and thermal disruption to eradicate indwelling biofilms
Marcus Horwitz UCLA Development of a new class of antibiotics: near atomic resolution of the Francisella T6SS structure and identification of inhibitors of assembly and secretion

Team Science - Neuroscience

2013

Principal Investigator PI Institution Project Title
Thomas Carmichael
UCLA Stem Cell Therapy for Intracerebral Hemorrhage

Translational Neurodegeneration and Neural Repair Research

2014

Principal Investigator PI Institution Project Title
Michael Basso UCLA A new model of the slowly progressing degeneration in Parkinson's disease
Peyman Golshani UCLA Imaging pathological network dynamics in Huntington's disease
Jason Hinman UCLA Determining molecular synergism between white matter stroke and Alzheimer's disease
Feliz Schweizer UCLA Neuronal effects of PD related pesticides

UCLA California Behavioral Health Center of Exellence / CTSI Rapid Research Advances for Progress In Disparities (RRAPID) Mental Health Awards

2015

Principal Investigator PI Institution Project Title
Armen Arevian UCLA Personalized, Predictive Markers of Clinical Outcome in Mental Illness through Speech Analysis
Joseph Rojas UCLA Defining the myogenic niche for rotator cuff skeletal muscle regeneration by administration of hPSC-pericytes
Kate Wolitzky-Taylor UCLA Engaging Stakeholders to Identify Barriers to Delivering Evidence Based Treatment for Anxiety Disorders in Community Mental Health

UCLA Center for Autism Research and Treatment (CART) Pilot Awards

2016

Principal Investigator PI Institution Project Title
Weize Hong UCLA Investigating The Role of Amygdala Circuitry in ASD-Related Behavior
Michael Gandal UCLA Targeting Microglial Activation for Treatment of Autism Spectrum Disorder (ASD): A Proof-of-Concept, Target-engagement Study
David Hayes-Bautista, Amanda Gulsrud UCLA Latino Parents of Children with Autism: Understanding how Innovative Mobile Internet Technology can Increase Access to Care

2015

Principal Investigator PI Institution Project Title
Marco Iacoboni UCLA From seeing to participating: dysregulation of fuctional connectivity during action perception and imitation in autism spectrum disorder

2014

Principal Investigator PI Institution Project Title
Shafali Jeste,
Amanda Gulsrud
UCLA Early intervention targeting social communication in infants with tuberous sclerosis complex
Sandra Loo UCLA Brain oscillatory patterns associated with GABA/Glutamate signaling and cognition in ASD
Alcino Silva UCLA Immune activation during pre- and post-natal development causes social phenotypes in a mouse model of Tuberous

2013

Principal Investigator PI Institution Project Title
Hongjing Lu UCLA Impact of autism on action perception
Danny J.J. Wang UCLA Perfusion MRI and functional connectivity in ASD
Beate Rtiz UCLA The link between pre-conceptual and prenatal supplementary folic acid intake and ASD in the Danish National Birth Cohort (DNBC)

2012

Principal Investigator PI Institution Project Title
Nigel Maidment UCLA Role of endogenous opioids in cocaine and opiate abuse
Jennifer Levitt UCLA Glutamate in autism and early development

UCLA Center for Ulcer Research and Education (CURE): Digestive Diseases Research Center Pilot and Feasibility Study (PFS)

2016

Principal Investigator PI Institution Project Title
Jill Hoffman UCLA The role of CRHR2 signaling in enteric glial cell function during colitis
Elaine Hsiao UCLA Dissecting Molecular and Cellular Mechanisms for Communication Across the Microbiota-Gut-Brain Axis
Marina Koutsioumpa UCLA Characterization and therapeutic targeting of ING3 chromatin pathway in pancreatic cancer
David Padua UCLA The Role of the Long-Noncoding RNA, CKDN2B-AS1, in Inflammatory Bowel Disease

2015

Principal Investigator PI Institution Project Title
Kyriaki Bakirtzi UCLA Identification and characterization of IBD-associated exosomes; horizontal gene transfer between the adipose and intestinal tissues
John Colicelli UCLA Regulation of RAB5 GTPase activity during Listeria monocytogenes infection
Alexandra Drakaki UCLA Molecular mechanisms and targeting of miR-9 in hepatocellular oncogenesis
Maria Hatziapostolou UCLA (not available)
Jonathan Jacobs UCLA The effect of an inflammatory bowel disease associated enterotype and metabotype on colitis in humanized gnotobiotic mice
Leanne Jones UCLA Characterizing the role of Tricellulin in intestinal disease
Swapna Joshi UCLA Colonic mucosal micro RNA and gene expression associated pathways and their correlation with dysbiosis in colonic mucosa in Irritable bowel Syndrome
Yoko Kidani UCLA Investigating the effect of lipid metabolism on Th17/Treg balance in gut immunity
DeChen Lin Cedars-Sinai Identification and characterization of super-enhancer driven transcripts in esophageal cancer through functional genomic approaches
Claudia San Miguel UCLA The role of adipokines as moderators and mediators of brain structure/activity signatures and their association with ingestive behaviors and weight loss after bariatric surgery
Claudio Scaofglio UCLA Combination treatments with sodium-glucose transporter 2 inhibitors in pancreatic cancers
Ali Sedarat UCLA Randomized controlled study of patients with severe refractory or recurrent peptic ulcer bleeding
Heloisa Soares UCLA Negative feedback loops by MEK/ERK and PI3K/AKT/mTOR in pancreatic cancer
Iina Tuomenin UCLA Determining the functional role of Stard3nl in liver fibrosis
Elizabeth Volkman UCLA Integrative analysis of the colonic microbiota and gastrointestinal dysfunction in systemic sclerosis

2014

Principal Investigator PI Institution Project Title
Stavroula Baritaki UCLA Effects of corticotrophin releasing hormone receptor 2 (CRHR2) in modulating colon cancer immunoescape through Fas/FasL regulation
Kai Fang UCLA Regulation of colitis by miR-221-5p and miR-222 3p-neurokinin receptor interactions
Cynthia Hong UCLA Regulation of intestinal lipid metabolism by IDOL
Haofeng Ji UCLA Neuroregulation in hepatic ischemia/reperfusion injury in orthotopic liver transplantation: immunomodulation via PKA-CREB-KL4 pathway
Thomas Vallim UCLA Central role of FXR-MAFG in bile acid homeostasis and inflammation

2013

Principal Investigator PI Institution Project Title
Christos Polytarchou UCLA The role of miR-21 expression in ulcerative colitis-associated colorectal cancer initiation and progression
Kathleen Hertzer UCLA Understanding the link between diet, inflammation, and pancreatic cancer
Katrin Hacke UCLA A novel chemoselection strategy for hematopoetic stem cell transplantation in IBD
Martin Martin UCLA Peptidomic survey of regulated hormone secretion from human small intestinal mucosa derived from a subject with a germ-line mutation of PCSK1
Timothy Donahue UCLA Targeting micro RNA 21 in human pancreatic cancer

UCLA/CDU Resource Centers for Minority Aging Research Center for Improvement of Minority Elderly (RCMAR/CHIME) and CTSI

2016

Principal Investigator Institution Project Title
Maria Marquine UC San Diego Successful Aging among Latinos (SAL)
Courtney Thomas UCLA Racial Identity as a Resource for Healthy Aging: Improving Psychosocial Resilience among Older African Americans
April Thames UCLA Accelerated Cognitive Aging as a Function of HIV and Lifetime Stress/Adversity

2015

Principal Investigator Institution Project Title
Cleopatra Abdou-Kamperveen USC Psychosocial mediators and moderators of healthcare stereotype threat in older African Americans and Latinos
Brandon Brown UC Riverside Differences in age and ethnicity in HIV testing and perceptions of HIV risk in the Coachella Valley
Annie Lu Nguyen USC HIV management and successful aging in men from communities of color
Yuying Tsong Cal State Fullerton Vietnamese American older adults’ mental health literacy and help seeking
Arturo Vargas Bustamante UCLA Factors affecting hypertension risk awareness and self-management among socially isolated Mexican-American older adults

2014

Principal Investigator Institution Project Title
Homero del Pino UCLA Exploring the sexual risk behaviors of older HIV+ men who have sex with men
Maisha T. Robinson UCLA Closing the gap about crossing over: Addressing the disparity in advance-care planning in elderly African Americans
Efrain Talamantes UCLA The impact of age, race and ethnicity on kidney transplant mortality

2013

Principal Investigator Institution Project Title
Nazleen Bharmal UCLA Cultural adaptation of stroke risk reduction curriculum for low-income South-Asian older adults
Jung-Ah Lee UC Irvine The use of innovative mobile health technology among elderly Hispanics on anticoagulation therapy
Annie Lu Nguyen USC Behaviors related to diabetes management among elderly Latino patients see at a federally qualified health center

2012

Principal Investigator Institution Project Title
Luisa Blanco RAND/Pepperdine Financial exclusion and the wellbeing of minority elders in the United States
Sarah Choi UC Irvine Diabetes self-care program for older Korean immigrants and their spouses
Homero del Pino UCLA Exploring the social support of gay men in sobriety

2011

Principal Investigator Institution Project Title
Adrianna Izquierdo UCLA Familism, social support, stress, and depressive symptoms among older Latinos in the United States: The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) Study
Aurelia Macabasco-O’Connell Azusa Pacific University Testing the effectiveness of an intensive dietary sodium intervention in elderly Latinos with chronic health failure
Sylvia Paz UCLA Language equivalence in Patient-Reported Outcomes Measurement Information System (PROMIS®) physical functioning measure
Sarah Song Rush University A community partnered approach to improving stroke symptom recognition and response in elderly Korean-Americans

UCLA CTSI-Los Angeles County Department of Health Services Collaboration Grants

2013

Principal Investigator PI Institution Project Title
Tony Kuo LA County Dept pf Public Health Identifying Opportunities and Examining Evidence-Based Programs to Improve the Health of Youth in Los Angeles County
Kenny Yat-Choi Kwong LA BioMed/Harbor Prospective study of asthma control, asthma morbidity, quality of life (QOL) and health care expenditure in asthmatic children during transition from acute care at Harbor-UCLA Medical Center (HUMC) back to community managed care organizations
Carol Mangione UCLA Implementation of a Primary Care-Based Teleretinal Screening Protocol for the Los Angeles County Safety Net
Kenneth Wells
Kristin Ochoa
UCLA Los Angeles County Psychiatric Emergency Room Outcomes Study
Theodore Friedman UCLA An innovative program to deliver obesity services at DHS facilities

UCLA CTSI-USC-Los Angeles County Department of Health Services Implementation Science Award

2017

Principal Investigator PI Institution Project Title
Dong Chang LA BioMed Time Limited Trials to Reduce Non‐Beneficial Intensive Care Unit Treatments Among Critically‐Ill Patients with Advanced Medical Illnesses
Eizabeth Pyatak USC Addressing Uncontrolled Diabetes in Primary Care: A Lifestyle Redesign Approach
Kenneth Zangwill LA BioMed Discontinuation of Antimicrobial Prophylaxis After Surgical Incision Closure

Business of Science Venture Team Awards

CTSI supports the Business of Science Center Venture Team Program, which pairs faculty inventors with graduate students from such areas as law, business, medicine, life science, physical science and engineering. The teams compete for proof-of-concept awards, which are partly funded by CTSI. More information about the Venture Team Program can be found here.

Core Voucher Award

The UCLA Clinical and Translational Science Institute (CTSI) provides the infrastructure to translate scientific discoveries into innovations that improve health in Los Angeles and the nation. To achieve its mission and advance translational research, the CTSI periodically awards vouchers to defray the cost of core services. Under this RFA, the CTSI will award vouchers worth up to $10,000 in core services to investigators at all CTSI partner institutions (UCLA Westwood, Cedars-Sinai, LA BioMed at Harbor-UCLA, and Charles R. Drew University).

Eligibility

Principal Investigator

  • UCLA Westwood: All full-time faculty with appointments in any of the Professorial Series, as well as clinical instructors in the School of Medicine, are eligible to apply. Junior Investigators (within 5 years of their academic appointment) will receive priority consideration. More information regarding the Professorial Series may be obtained at: https://www.apo.ucla.edu/policies/the-call/professorial-series.

    Investigators with appointments in the Professional Research Series (defined at: https://www.apo.ucla.edu/policies/the-call/professional-research-series) may apply by one of two mechanisms. (1) Those participating in supervised research should apply under their lab mentor’s name as a Co-Investigator. (2) Those requesting support for projects that are independent of their lab mentor may be eligible to apply directly, but must first contact Elvira Liclican (eliclican@mednet.ucla.edu) no later than March 17, 2017, prior to submitting their application.

  • Cedars-Sinai: All Cedars-Sinai faculty are eligible to apply; junior faculty (Assistant Professor or equivalent) will receive priority consideration. For questions about eligibility, please contact Debby Peterson (debby.peterson@cshs.org).

  • LA BioMed at Harbor-UCLA: All full-time investigators are eligible to apply; junior investigators (within 5 years of their academic appointment) will receive priority consideration. For questions, please contact Raquel Gutierrez (gutierrez@labiomed.org ).

  • Charles R. Drew University (CDU): All CDU faculty are eligible to apply.

Each eligible Principal Investigator may submit one and only one application.

Co-Investigator (1 per application)

  • Non-faculty researchers (professional researchers, project scientists, research scientists, postdoctoral fellows, and graduate students) are eligible to be listed as a Co-Investigator on a faculty member’s application. Please note that a faculty member may still only submit one application.

Previous voucher recipients may apply only if a different proposal is being submitted. Continuations/extensions of previously awarded proposals are not eligible.

Application Requirements and Processes

All applications must be submitted through the online system. Applications may be submitted March 6 – April 7, 2017 only. Please carefully follow all instructions on the application.

Applicants must have a UCLA logon ID (previously known as BOL) to access the online application. One may be obtained at: https://logon.ucla.edu. Applicants are encouraged to complete this process well in advance of the application deadline.

Investigators must be pursuing a project that could immediately benefit from access to the more than 65 cores located on the LA BioMed at Harbor-UCLA, Cedars-Sinai, or UCLA Westwood campuses. A partial list of cores can be found here. For questions about cores not listed, please contact Elvira Liclican.

Applicants must provide the following:

  • Project description demonstrating need for specific core(s). (maximum 2000 characters including white spaces, ≈ 300 words)
  • Budget justification for the requested core(s). (maximum 500 characters including white spaces, ≈ 80 words)
  • Description of the availability of samples, specialized reagents, constructs, technology, etc. required for the core services requested. If not currently available, describe the timeline for obtaining such material. (maximum 500 characters including white spaces, ≈ 80 words)
  • For previous voucher awardees, justification for any possible overlap between this proposal and previously awarded voucher. (maximum 500 characters including white spaces, ≈ 80 words)
  • Current biosketch(es) that includes a list of current and pending funding in PDF format – please merge Principal Investigator and Co-Investigator biosketches into one PDF file, if applicable.

Applicants must adhere to the strict character limit and biosketch file format to ensure a successful submission.

Proposals will be reviewed and ranked based on:

  1. Translatability – Does the proposal directly address a significant problem in human health? Will the project provide valuable information and likely advance towards clinical utilization in the near future? Will the knowledge gained from this proposal transform clinical practice?
  2. Innovation – Does the project address the health problem with a novel, unique approach? This component is given the highest priority.
  3. Core Utilization – Is the project feasible? Does the experimental approach optimally utilize the capabilities of the core(s)? Can the requested core services be completed within the next 6 months? If your research requires IRB and/or IACUC approval, are the relevant protocol approvals in place?

Applicants are highly encouraged to discuss their proposals and budget with the relevant cores and core directors prior to submitting the application.

An acknowledgment e-mail will be automatically sent once an application is successfully submitted.

Additional Requirements

Awarded investigators will be required to provide their NIH eRA Commons ID, their field of specialization, and their IRB, IACUC, and/or ESCRO numbers if applicable. Proposals must be ready to begin using core services as soon as vouchers are awarded - all IRB, IACUC, and ESCRO approvals must be in place at the time of award.

Voucher awards must be expended within 8 months of award notification. Recipients must disclose the UCLA CTSI grant number UL1TR001881 as a funding source to the IRB and/or ARC as applicable, and must cite the grant in all publications that result from this CTSI-supported research. In addition, voucher recipients must report the following information to the UCLA CTSI by November 30 each year:

  1. All publications that resulted from CTSI-supported research with PubMed ID
  2. All PHS and non-PHS federal support that contributed to the CTSI-supported research

Deadlines

Completed applications must be submitted March 6 – April 7, 2017 only. Submission closes at 5 pm on Friday, April 7, 2017. Awards are expected to be announced late June 2017.

Contact Information

For questions regarding the content and scope of this RFA, or faculty eligibility, please contact:

For technical difficulties regarding the online application process, please contact:

Core Voucher Award - LA BioMed Only

The UCLA Clinical and Translational Science Institute (CTSI) provides the infrastructure to translate scientific discoveries into innovations that improve health in Los Angeles and the nation. Under this RFA, the CTSI will award vouchers worth up to $5,000 in CTRC services (Nursing, Bionutrition, DEXA, Lab, biomedical informatics, study design and biostatistical analyses and other clinical cores on campus etc.), for a maximum of two different core services, to investigators at LA BioMed at Harbor-UCLA. For a full list of core services, please access the application link. 

Eligibility
All full-time LA BioMed investigators are eligible to apply; junior investigators (within 5 years of their academic appointment) will receive priority consideration.

Each eligible Principal Investigator may submit only one application.

Applications are due by August 31, 2017. Awards are expected to be announced late September 2017.

For questions, please contact Raquel Gutierrez gutierrez@labiomed.org, or (310) 222-2503.

Core Voucher Award - UCLA Westwood Only

The UCLA Clinical and Translational Science Institute (CTSI) provides the infrastructure to translate scientific discoveries into innovations that improve health in Los Angeles and the nation. To achieve its mission and advance translational research, the CTSI periodically awards vouchers to defray the cost of core services. Under this RFA, the CTSI will award vouchers worth up to $8,000 in core services to investigators from UCLA Westwood only (investigators located at the Cedars-Sinai, Charles R. Drew University and LA BioMed at Harbor-UCLA campuses are not eligible to apply for this RFA). This rolling RFA will stay open while funds exist or until December 1, 2015 at the latest. Applications will be reviewed and scored in the order in which they are submitted. Each eligible PI may submit only one application through the rolling RFA.

Eligibility

Principal Investigator

All UCLA Westwood full-time faculty with appointments in any of the Professorial Series, as well as UCLA Westwood clinical instructors in the School of Medicine, are eligible to apply. Junior Investigators (within 5 years of their academic appointment) will receive priority consideration. More information regarding the Professorial Series may be obtained at: https://www.apo.ucla.edu/policies/the-call/professorial-series.

UCLA Westwood Investigators with appointments in the Professional Research Series (defined at: https://www.apo.ucla.edu/policies/the-call/professional-research-series) may apply by one of two mechanisms. (1) Those participating in supervised research should apply under their lab mentor's name as a Co-Investigator. (2) Those requesting support for projects that are independent of their lab mentor may be eligible to apply directly, but must first contact the CTSI Center for Translational Technologies (CTT) prior to submitting their application. Eligibility decisions will be made on a case-by-case basis within 1-2 days of contacting the CTT.

Each eligible Principal Investigator may submit one and only one application.

Co-Investigator (1 per application)

UCLA Westwood Non-faculty researchers (professional researchers, project scientists, research scientists, postdoctoral fellows, and graduate students) are eligible to be listed as a Co-Investigator on a faculty mentor's application. Please note that a faculty member may still only submit one application.

Previous voucher recipients may apply only if a different proposal is being submitted. Continuations/extensions of previously awarded proposals are not eligible.

Application Requirements and Processes

All applications must be submitted through the online system. Please carefully follow all instructions on the application. Applicants will be notified of award status within 2 - 3 weeks from submission. Each eligible PI may submit only one application through the rolling RFA.

Applicants must have a UCLA logon ID (previously known as BOL) to access the online application. One may be obtained at: https://logon.ucla.edu

Investigators must be pursuing a project that could immediately benefit from access to the more than 65 cores located on the LA BioMed at Harbor-UCLA, Cedars-Sinai, or UCLA Westwood campuses. A partial list of cores can be found here. For questions about cores not listed, please contact CTT

  • Project description demonstrating need for specific core(s) (maximum 2000 characters including white spaces, - 300 words)
  • Budget justification for the requested core(s) (maximum 500 characters including white spaces, - 80 words)
  • For previous voucher awardees, justification for any possible overlap between this proposal and previously awarded voucher (maximum 500 characters including white spaces, - 80 words)
  • Current biosketch(es) in NIH format. Please merge Principal Investigator and Co-Investigator biosketches into one PDF file, if applicable

Applicants must adhere to the strict character limit and biosketch file format to ensure a successful submission

Proposals will be reviewed and ranked based on:

  1. Translatability - Does the proposal directly address a significant problem in human health? Will the project provide valuable information and likely advance towards clinical utilization in the near future? Will the knowledge gained from this proposal transform clinical practice?
  2. Innovation - Does the project address the health problem with a novel, unique approach? This component is given the highest priority.
  3. Core Utilization -Is the project feasible? Does the experimental approach optimally utilize the capabilities of the core(s)? Can the requested core services be completed within the next 6 months? If your research requires IRB and/or IACUC approval, are the relevant protocol approvals in place?

Applicants are highly encouraged to discuss their proposals and budget with the relevant cores and core directors prior to submitting the application.

An acknowledgment e-mail will be automatically sent once an application is successfully submitted.

Additional Requirements

Awarded investigators will be required to provide their NIH eRA Commons ID, their field of specialization, and their IRB, IACUC, and/or ESCRO numbers if applicable. Proposals must be ready to begin using core services as soon as vouchers are awarded - all IRB, IACUC, and ESCRO approvals must be in place at the time of award.

Voucher awards must be expended within 10 months of award notification. Recipients must disclose the UCLA CTSI grant number UL1TR000124 as a funding source to the IRB and/or ARC as applicable, and must cite the grant in all publications that result from this CTSI-supported research. In addition, voucher recipients must report the following information to the UCLA CTSI by November 30 each year:

  1. All publications that resulted from CTSI-supported research with PubMed ID
  2. All PHS and non-PHS federal support that contributed to the CTSI-supported research

Deadlines

This rolling RFA will stay open while funds exist or until December 1, 2015 at the latest. Applicants will be notified of award status within 2 -3 weeks from submission.

Contact Information

For questions regarding the content and scope of this RFA or faculty eligibilty, please contact:

Elvira Liclican, PhD
Science Officer, UCLA CTSI Center for Translational Technologies
Office: (310) 825-3518
E-Mail: eliclican@mednet.ucla.edu

For technical difficulties regarding the online application process, please contact Computing Technologies Research Lab (CTRL) at (310) 206-6556 or rfp-support@ctrl.ucla.edu.

CTRC Seed Grant

Apply Here

The CTRC Seed Grant Program is designed to foster pilot studies that use CTRC facilities and staff with the goal of developing these into larger, successful, extramurally funded projects. CTSI expects to fund up to five proposals at each site under this RFP.

These Seed Grant Awards are expected to (1) lead to investigator initiated larger projects that will be appropriate for independent extramural funding, (2) make significant use of the CTRC services, especially nursing and nutrition, and (3) result in at least one peer-reviewed publication.

About the CTRC 
The Clinical and Transitional Research Centers (CTRC) at Cedars-Sinai, Charles R. Drew University, LA BioMed/Harbor-UCLA and the UCLA Westwood campus provide nursing, nutrition and laboratory support for outstanding clinical research, including clinical trials at all stages—phase I studies to multi-center trials. The centers are funded by the CTSI grant (NCATS UL1TR000124) to promote and assist in the conduct of clinical and translational research. The various sites have different expertise and availability of services, including inpatient stays, outpatient visits, bionutrition services and other servcies. www.ctsi.ucla.edu/ctrc

Seed Grant Program Eligibility
 To apply, applicants or mentors must be on the faculty at one of the UCLA CTSI partner institutions; faculty with academic appointments at UCLA, CDU, or Cedars-Sinai, are eligible. Collaboration among researchers at multiple campuses is encouraged and can be facilitated if needed. Researchers or emerging investigators focused on health disparities and/or disabilities are encouraged to apply.

LOI Submission 
The LOI is limited to 2500 characters in addition to NIH formatted biosketches for all investigators and collaborators. The LOI will need to be submitted in PDF format electronically. Applicants will be notified of their eligibility to submit a full application.

Deadlines
 Awards will be determined based on letter of intent (LOI) and project proposal with a maximum duration of 18 months.

  • Release of call for proposals March 14, 2014
  • Letter of intent due April 21, 2014
  • Notification of request for full proposal May 9, 2014
  • Full project proposal, if requested, due June 4, 2014
  • Projects awarded July 15, 2014 for immediate implementation

Future cycles of proposals are anticipated twice per year dependent on funding.

Please direct CTRC questions to:

For technical difficulties, contact Computing Technologies Research Lab (CTRL) at (310) 206-6556 or rfp-support@ctrl.ucla.edu.

For more information http://www.ctsi.ucla.edu/funding/pages/ctrcseed.

David Geffen School of Medicine Seed Grant Program

The David Geffen School of Medicine Research Themes have been charged with increasing the impact of basic, translational, clinical, and community research at UCLA in high-priority and broadly defined biomedical research areas. The Research Themes are also catalyzing the establishment of multidisciplinary teams that can promote innovative thinking and lead to groundbreaking discoveries. To allow UCLA faculty and teams of faculty to pursue their innovative new ideas, we are pleased to announce the establishment of a greatly enhanced David Geffen School of Medicine (DGSOM) Seed Grant Program, developed in close collaboration with the DGSOM Research Themes, the Jonsson Comprehensive Cancer Center, the Clinical and Translational Science Institute, and key donors.

The results obtained in studies funded by the seed grants promise to advance our understanding of fundamental biological processes and human disease, lead to novel therapeutic or diagnostic strategies to improve human health, or suggest improved strategies for healthcare delivery or for reducing healthcare disparities. The results are also expected to lead to larger extramural grants from the National Institutes of Health or from other funding agencies or foundations.

Important Dates:
April 15, 5PM - Letters of Intent (LOI) Due
April 30 - LOI Decisions Announced
May 31, 5PM - Full Applications Due (By Invitation Only)
June 30 - Final Decisions Announced
August 1 - Earliest Funding Date 

Applications from both individual faculty and research teams are encouraged via a centralized mechanism that has been established for the submission of Letters of Intent (LOIs) and full applications. Submitted LOIs and applications will be reviewed by committees assembled by each of the six Research Themes:
  • Cancer (Jonsson Comprehensive Cancer Center)
  • Cardiovascular Medicine
  • Immunity, Inflammation, Infection, and Transplantation (I3T)
  • Metabolism
  • Neuroscience
  • Regenerative Medicine (Broad Stem Cell Research Center)
Each Theme will distribute a total of at least $400,000 for the 2017 competition. A seventh review committee will evaluate LOIs and applications that do not fit under the umbrella of any of the six Themes. The lead Principal Investigator on each application must hold a primary appointment on the UCLA campus (specifically, their extramural grant applications must typically be submitted through the UCLA Office of Contract and Grant Administration).

The leadership of each of the six Themes has defined funding amounts and specific criteria for solicited applications. Please see the “Theme-Specific Programs and Criteria” on the DGSOM Seed Grant Program page for additional information.

Read the complete details and submit your LOI here.  

Generous funding for this program is provided by the Spitzer Family Foundation, the Jonsson Cancer Center Foundation (for Cancer grants), the UCLA Clinical and Translational Sciences Institute, and the DGSOM Dean’s Office.

Contact Information
Please direct questions to Dion Baybridge at DBaybridge@mednet.ucla.edu.

Iris Cantor Women's Health Center / CTSI - Augmentation Awards

Funding Available for Augmentation of Major Research Grants:
Iris Cantor-UCLA Women’s Health Center / CTSI - Executive Advisory Board Awards

Pilot funding is available to augment currently funded NIH or major foundation grants for UCLA researchers, this includes researchers at the Westwood/Santa Monica Campus, Cedars Sinai Medical Center, LA BioMed at Harbor-UCLA and Charles R. Drew University of Medicine and Science, to promote exploration of sex and gender-based differences and women’s health research. Funds can be used to focus on, expand, or strengthen a research project’s applicability to women’s health.

Research Proposed through Funding from the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health should be consistent with the mission of the Center:

The Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health seeks to promote comprehensive health care for women by providing support for research to understand human sex differences in health and disease and medical issues and diseases unique to women, as well as to develop and test clinical interventions for women. An equally important component of the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health mission is training future leaders in women’s health research. Specific aims include:

  • To encourage and support interdisciplinary research in the field of women’s health and gender-based medicine, including:
    • To study medical issues (including reproductive issues) and diseases unique to women and more common in women 
    • To use established methods of health, utility, and cost measurement to assess and suggest ways to improve the cost effectiveness of clinical interventions for women. 
    • To promote research on sex at the cellular level, including how genetic sex differences influence cells, organs, organ systems, and organisms 
    • To study sex differences across the life span 
    • To study sex differences and similarities for human diseases that affect both sexes 
  • To train researchers capable of leading and conducting research programs that are consistent with the mission of the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health 
  • To extend resources into the UCLA campus to increase the quality of women’s health research throughout the campus and to attract new and established researchers into women’s health research 
  • To study a wide range of populations in these research efforts, including women of diverse racial and ethnic backgrounds, and those who have been traditionally underrepresented in research studies 
  • To translate research findings into improvements in health care practice for women

A list of prior awarded projects is available at the Iris Cantor-UCLA Women’s Health Center Website.

Co-Sponsorship: The UCLA Clinical and Translational Science Institute (UCLA CTSI) is co-sponsoring this award made available by the Iris Cantor-UCLA Women’s Health Center. The CTSI provides the infrastructure to bring UCLA innovations and resources to bear on the greatest health needs of Los Angeles and the nation. It is a dynamic partnership among UCLA Westwood, Charles Drew University of Medicine and Science, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, the Burns and Allen Research Institute at Cedars-Sinai Medical Center and our Los Angeles community. It is one of more than 60 NIH-funded CTSIs nationwide.

Funding Amount Available: $30,000 one-year awards.

Pilot Submission Timeline and Selection Process
Submit a one-page letter of intent and biosketch by e-mail for review. All submissions from interested UCLA faculty must be received by noon, Tuesday, January 24, 2017 (see contact information below). The letter should indicate/include:

  • Abstract of planned pilot research project
  • Relationship of planned project to Center mission and aims
  • Long range research goals for this pilot work for future research 
  • Whether the research is a new or augmented pilot research project
  • For applications that are attempting to collect additional preliminary data in response to recent grant application reviews: include a complete copy of the grant application review (attachment) and specifically identify the critique that will be addressed by the proposed work (in the letter of intent). 
  • For any augmentation requests, how additional funds will strengthen current pilot and specify how increased budget amount would be used in your pilot work
  • Budget amount requested 
  • NIH biosketch(s) of investigators (attachments)
  • Contact information for investigators (street address, email address, and phone number)

Investigators may request up to $30,000 for a one-year period.

The Review Committee will review letters of intent and contact investigators whom they wish to submit full pilot proposals by Monday, March 20, 2017. Funded projects will begin July 1, 2017 for the period July 1, 2017 through June 30, 2018

Criteria for selection include: (a) quality of the proposed research; (b) credentials of PI and Co-investigators (if included); (c) relatedness to the relevant Center theme and mission. Funding may be requested for any purpose which meets the needs of the investigator (s) and complies with UCLA policies for expenditure of funds.  Please note that highest priority for the pilots will be given to pilots that would likely lead to R01s (or equivalent level funding from extramural sources) consistent with the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health mission within 2-3 years. 

Successful applicants may be asked to attend a team science training.

Submission of Letter of Intent
The letter of intent, biosketch(s), and other attachments should be e-mailed to the attention of Karen Singh, ktsingh@mednet.ucla.edu; (310-794-8063). The letter of intent, biosketch(s), and other requested materials must be received by noon, Tuesday, January 24th, 2017. Any materials received after noon, Tuesday, January 24th, 2017 will not be considered

Iris Cantor Women's Health Center / CTSI - Cervical Cancer Awards


Marcia Leavitt Cervical Cancer Research Fund:
Pilot Funding Available from the Iris Cantor-UCLA Women’s Health Center

This award is open to the four CTSI partner institutions.

Pilot funding is available for research related to the prevention and treatment of cervical cancer.  Basic scientists, clinical researchers, and public health and health services researchers are strongly encouraged to apply.

The Iris Cantor-UCLA Women’s Health Center invites submission of projects for pilot funding addressing the following issues:

  • To encourage and support research, including interdisciplinary research, in the field of cervical cancer, including:
    • To study medical issues (including reproductive issues) and diseases unique to women and more common in women
    • To use established methods of health, utility, and cost measurement to assess and suggest ways to improve the cost effectiveness of clinical interventions for women.
    • To promote research on sex at the cellular level, including how genetic sex differences influence cells, organs, organ systems, and organisms
    • To study sex differences across the life span
    • To study sex differences and similarities for human diseases that affect both sexes
  • To train researchers capable of leading and conducting cervical cancer research programs
  • To extend resources to increase the quality of cervical cancer research throughout UCLA and affiliated institutions

Funding Amount Available: Up to $75,000 for a two year period

Pilot Submission Timeline and Selection Process
a. Submit a one-page letter of intent and NIH biosketch by email for review. All submissions from interested UCLA faculty must be received by noon, Tuesday, January 26, 2016 (see contact information below). The letter should indicate/include:

  • Abstract of planned pilot research project
  • Long range research goals for this pilot work for future research
  • Whether the research is a new or augmented pilot research project
  • For any augmentation requests, how additional funds will strengthen current research and specify how increased budget amount would be used in your pilot work
  • Budget amount requested
  • NIH biosketch(s) of investigators (attachments)

Investigators may request up to $50,000 for a one-year period, or $75,000 for a two-year period.

The Review Committee will review letters of intent and contact investigators whom they wish to submit full pilot proposals by Monday, March 21, 2016. Funded projects will begin Friday, July 1, 2016.

Criteria for selection include: (a) quality of the proposed research; (b) potential of the research to expand understanding of cervical cancer; (c) potential of the pilot funding to expand capacity for research on this topic at UCLA and affiliated sites; and (d) credentials of PI and Co-investigators (if included). Funding may be requested for any purpose which meets the needs of the investigator(s) and complies with UCLA policies for expenditure of funds. Please note that highest priority for the pilots will be given to pilots that would likely lead to R01s (or equivalent level funding from extramural sources) within 2-3 years.

Successful applicants may be asked to attend a team science training. 

Submission of Letter of Intent
The letter of intent, biosketch(s), and other attachments should be emailed to the attention of Ani Isayan, aisayan@mednet.ucla.edu; (310-794-8063). The letter of intent, biosketch(s), and other requested materials must be received by noon, Tuesday, January 26, 2016. Any materials received after noon, Tuesday, January 26, 2016 will not be considered.

Iris Cantor Women's Health Center / CTSI - Pilot Awards


Pilot Funding Available for Research in Women’s Health:
Iris Cantor-UCLA Women’s Health Center Executive Advisory Board/CTSI Awards

Pilot funding is available for UCLA researchers, this includes researchers at the Westwood/Santa Monica Campus, Cedars-Sinai Medical Center, LA BioMed at Harbor-UCLA and Charles R. Drew University of Medicine and Science, who perform women’s health research, and/or research where exploration of sex and gender-based differences is relevant.  

Research Proposed through Funding from the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health should be consistent with the mission of the Center:

The Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health seeks to promote comprehensive health care for women by providing support for research to understand human sex differences in health and disease and medical issues and diseases unique to women, as well as to develop and test clinical interventions for women. An equally important component of the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health mission is training future leaders in women’s health research. Specific aims include:

  • To encourage and support interdisciplinary research in the field of women’s health and gender-based medicine, including:
    • To study medical issues (including reproductive issues) and diseases unique to women and more common in women
    • To use established methods of health, utility, and cost measurement to assess and suggest ways to improve the cost effectiveness of clinical interventions for women.
    • To promote research on sex at the cellular level, including how genetic sex differences influence cells, organs, organ systems, and organisms
    • To study sex differences across the life span
    • To study sex differences and similarities for human diseases that affect both sexes
  • To train researchers capable of leading and conducting research programs that are consistent with the mission of the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health
  • To extend resources into the UCLA campus to increase the quality of women’s health research throughout the campus and to attract new and established researchers into women’s health research
  • To study a wide range of populations in these research efforts, including women of diverse racial and ethnic backgrounds, and those who have been traditionally underrepresented in research studies
  • To translate research findings into improvements in health care practice for women

A list of prior awarded projects is available at the Iris Cantor-UCLA Women’s Health Center Website.

Co-Sponsorship: The UCLA Clinical and Translational Science Institute (UCLA CTSI) is co-sponsoring this award made available by the Iris Cantor-UCLA Women’s Health Center. The CTSI provides the infrastructure to bring UCLA innovations and resources to bear on the greatest health needs of Los Angeles and the nation. It is a dynamic partnership among UCLA Westwood, Charles Drew University of Medicine and Science, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, the Burns and Allen Research Institute at Cedars-Sinai Medical Center and our Los Angeles community. It is one of more than 60 NIH-funded CTSIs nationwide.

Funding Amount Available
: $30,000 one-year pilot awards for all types of research

Pilot Submission Timeline and Selection Process
a. Submit a one-page letter of intent and biosketch by e-mail for review. All submissions from interested UCLA faculty must be received by noon, Tuesday, January 24, 2017 (see contact information below). The letter should indicate/include:
  • Abstract of planned pilot research project
  • Relationship of planned project to Center mission and aims
  • Long range research goals for this pilot work for future research
  • Whether the research is a new or augmented pilot research project
  • For applications that are attempting to collect additional preliminary data in response to recent grant application reviews: include a complete copy of the grant application review (attachment) and specifically identify the critique that will be addressed by the proposed work (in the letter of intent).
  • For any augmentation requests, how additional funds will strengthen current pilot and specify how increased budget amount would be used in your pilot work
  • Budget amount requested
  • NIH biosketch(s) of investigators (attachments)
  • Contact information for investigators (street address, email address, and phone number)

Investigators may request up to $30,000 for a one-year period.

The Review Committee will review letters of intent and contact investigators whom they wish to submit full pilot proposals by Monday, March 20, 2017. Funded projects will begin July 1, 2017 for the period July 1, 2017 through June 30, 2018.

Criteria for selection include: (a) quality of the proposed research; (b) credentials of PI and Co-investigators (if included); (c) relatedness to the relevant Center theme and mission. Funding may be requested for any purpose which meets the needs of the investigator (s) and complies with UCLA policies for expenditure of funds. Please note that highest priority for the pilots will be given to pilots that would likely lead to R01s (or equivalent level funding from extramural sources) consistent with the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health mission within 2-3 years.

Successful applicants may be asked to attend a team science training. 

Submission of Letter of Intent
The letter of intent, biosketch(s), and other attachments should be e-mailed to the attention of Karen Singh, ktsingh@mednet.ucla.edu; (310-794-8063).  The letter of intent, biosketch(s), and other requested materials must be received by noon, Tuesday, January 24th, 2017.  Any materials received after noon, Tuesday, January 24th, 2017 will not be considered.

Iris Cantor Women's Health Center / CTSI - Young Investigator Awards


Fellowship Funding Available for Research in Women’s Health:
Iris Cantor-UCLA Women’s Health Center/CTSI Young Investigator Award

Fellowship funding is available for one Ph.D. candidate (including M.D. Ph.D. or other dual degree) or post-doctoral student engaged in research related to women’s health at UCLA, this includes candidates and students at the Westwood/Santa Monica Campus, Cedars-Sinai Medical Center, LA BioMed at Harbor-UCLA and Charles R. Drew University of Medicine and Science. 

Funding from the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health should be consistent with the mission of the Center:

The Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health seeks to promote comprehensive health care for women by providing support for research to understand human sex differences in health and disease and medical issues and diseases unique to women, as well as to develop and test clinical interventions for women. An equally important component of the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health mission is training future leaders in women’s health research. Specific aims include:

  • To encourage and support interdisciplinary research in the field of women’s health and gender-based medicine, including:
    • To study medical issues (including reproductive issues) and diseases unique to women or more common in women
    • To use established methods of health, utility, and cost measurement to assess and suggest ways to improve the cost effectiveness of clinical interventions for women.
    • To promote research on sex at the cellular level, including how genetic sex differences influence cells, organs, organ systems, and organisms
    • To study sex differences across the life span
    • To study sex differences and similarities for human diseases that affect both sexes
  • To train researchers capable of leading and conducting research programs that are consistent with the mission of the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health
  • To extend resources into the UCLA campus to increase the quality of women’s health research throughout the campus and to attract new and established researchers into women’s health research
  • To study a wide range of populations in these research efforts, including women of diverse racial and ethnic backgrounds, and those who have been traditionally underrepresented in research studies
  • To translate research findings into improvements in health care practice for women

Co-Sponsorship: The UCLA Clinical and Translational Science Institute (UCLA CTSI) is co-sponsoring this award made available by the Iris Cantor-UCLA Women’s Health Center. The CTSI provides the infrastructure to bring UCLA innovations and resources to bear on the greatest health needs of Los Angeles and the nation. It is a dynamic partnership among UCLA Westwood, Charles Drew University of Medicine and Science, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, the Burns and Allen Research Institute at Cedars-Sinai Medical Center and our Los Angeles community. It is one of more than 60 NIH-funded CTSIs nationwide.

Fellowship Funding Amount Available: $20,000 one-year fellowship

Pilot Submission Timeline and Selection Process
Submit a one-page letter of intent, full CV and NIH biosketch of applicant, and letter of support and NIH biosketch of principal mentor by email for review.  All submissions from interested UCLA students must be received by noon, Tuesday, January 24, 2017 (see contact information below).  The letter should indicate/include:

  • Summary of current research
  • Long range research goals and plans for future research
  • Budget specifying how the funds will be used
  • CV of proposed fellow and NIH biosketch (attachments)
  • Letter of support from principal mentor (attachment)
  • NIH biosketch of principal mentor (attachments)
  • Contact information for investigators (street address, email address, and phone number)

The Review Committee will review letters of intent and contact investigators whom they wish to submit additional information by Monday, March 20, 2017.  The fellowship will begin July 1, 2017 for the period July 1, 2017 through June 30, 2018.

Criteria for selection include: (a) Potential of the applicant’s work to further research in women’s health; (b) credentials of the applicant and mentor, and (c) relatedness to the Center mission. Funding may be requested for any purpose which meets the needs of the investigator and complies with UCLA policies for expenditure of funds. Please note that highest priority for the fellowship will be given to applicants whose research trajectory makes it likely that they will ultimately qualify for a faculty position at UCLA or at another academic medical center or research institute as an independently funded researcher consistent with the mission of the Iris Cantor-UCLA Women’s Health Center/UCLA National Center of Excellence in Women’s Health.

Successful applicants may be asked to attend a team science training.  

Submission of Letter of Intent
The letter of intent, biosketch(s), and other attachments should be e-mailed to the attention of Karen Singh, ktsingh@mednet.ucla.edu; (310-794-8063).  The letter of intent, biosketch(s), and other requested materials must be received by noon, Tuesday, January 24th, 2017.  Any materials received after noon, Tuesday, January 24th, 2017 will not be considered.

Junior Faculty Mentored-Research Award

Junior Faculty Mentored-Research Awards are available for junior faculty in any series within their first three years of appointment to support mentored training in translational research in all areas of investigation. Grants of a maximum of $30,000 will be awarded for a one-year period. Funding from this program cannot be used to support the PI’s salary. Applications will be accepted from MD or PhD junior faculty in any series at UCLA CTSI partnered and affiliated institutions, within their first 3 years of appointment.

The criteria for the selection include quality of the scientific proposal, the candidate’s potential for an independent translational research career, potential translational impact of the research and relevance to the overall translational research mission of the UCLA CTSI. Awarded Scholars will participate in CTSI research education and career development opportunities. Scholars will complete an annual progress report as part of their award requirements.

Multi-CTSI Team Science - (UCLA and University of Minnesota) Cross-Institutional Award

The Clinical and Translational Science Institutes (CTSIs) of UCLA and the University of Minnesota announce the 2012 Cross-Institutional Awards for Health Disparities Research and Health Systems Change. The awards are designed to improve health and health care in diverse communities through productive partnerships among researchers, clinicians, and community-based organizations.

Award Description

The Cross-Institutional Award for Health Disparities Research and Health Systems Change supports pilot projects that address health disparities and health systems problems of importance to Southern California and Minnesota. Awards are expected to lead to submission of an application for extramural funding. This opportunity will provide up to three, one-year awards of $50,000–$75,000 each.

Background

Translational research is focused on “translating” basic scientific discoveries into health interventions, and then moving those interventions into clinical practice to improve patient care and population health. Translational research aims to accelerate the pace of discovery, speed the application of new knowledge to novel prevention strategies, diagnostics and treatments, and transfer these innovations to health care providers and the public.

Clinical and Translational Science Institutes (CTSIs) provide the research infrastructure to support translational research. The CTSIs support pilot studies, train young researchers, and engage schools and communities in health improvement. The CTSI program is led by the National Center for Advancing Translational Sciences, part of the National Institutes of Health.

An important goal of the CTSI program is to effectively engage communities in translational research. This RFA seeks projects in which community-based organizations participate fully with faculty in the research process. Research questions must be relevant to community needs and community organizations must be involved in the formulation, execution, analysis, interpretation and dissemination of the research.

RFA is available hereLetters of Intent are due by October 1, 2012Click here to submit your LOI.

Multi-CTSI Team Science - (UCLA and USC/CHLA) Healthy Aging in Los Angeles

In partnership with the Los Angeles County Department of Health Services (LAC DHS) and the Department of Public Health (LAC DPH), the University of California, Los Angeles (UCLA) Clinical and Translational Science Institute (CTSI), and the Southern California Clinical and Translational Science Institute (SC CTSI) at the University of Southern California (USC) and Children’s Hospital Los Angeles (CHLA), announce the 2014 Multi-CTSI (UCLA; and USC/CHLA) Healthy Aging in Los Angeles Team Science Award to advance aging research and to promote healthy aging for older adults throughout Los Angeles County.

Purpose

The awards are designed to: (i) pursue the goal of healthy aging in Los Angeles County through collaborations with communities and community members; all appropriate levels of government; and practitioners of medicine, nursing, dentistry, physical therapy, occupational therapy, public health and mental health; and (ii) to advance the effort to develop, evaluate and disseminate a coordinated set of interventions intended to promote healthy aging in Los Angeles County.

Healthy aging is broadly conceived as relating to physical, emotional and social health. It involves diverse constructs such as physical activity and fitness, mobility, ability to age "in place," ability to take care of basic needs, maintenance of meaningful social interaction with others, and health care interventions that prevent, slow or mitigate the impact of chronic conditions among older populations, including mental health and substance use.

The target population of successful proposals should not focus exclusively on elderly populations. Applicants are encouraged to consider accelerated aging in minority and socioeconomically disadvantaged communities in selecting the target population. Populations aged 50 years and older should be the primary focus, recognizing that health benefits in the younger part of the continuum may not be immediately evident. Applicants are encouraged to consider multi-generational approaches to healthy aging, such as involving older individuals with school-age children or youth. While the primary focus is older populations, a life course orientation is encouraged within teams.

Examples of topical areas include but are not limited to: health behaviors, health literacy and self-management, and special/vulnerable populations. Proposals that focus exclusively on medical treatment for older adults without attention to other domains of health and well-being will not be considered responsive to this guidance. Multidisciplinary approaches are a requirement of team science funding.

Award

Each research team will receive up to $50,000 for a period of up to one year. These funds must be matched by an equal dollar amount or in-kind support from the home institution(s)/departments(s)/community partner. NIH guidelines for annual and end-of-project reporting will apply. Carry forward of funds is not allowed. Up to four awards will be funded.

Eligibility

Each application must include Co-PIs, with one from LAC DHS or DPH, and at least one associated from either the UCLA CTSI or SC CTSI at USC/CHLA.

Teams must include a partner from at least one community-based organization, including but not limited to health or service agencies and organizations, community clinics, health care or public health providers, policy makers and lay groups with health concerns. It is expected that investigators and community partners will participate fully and equitably in the research process. A CBO or FBO partner is eligible to serve as Co-PI.

UCLA CTSI
As PI: Faculty associated with UCLA and UCLA CTSI institutional partners (Cedars-Sinai Medical Center, Charles R. Drew University of Medicine and Science and Los Angeles Biomedical Institute at Harbor-UCLA Medical Center), and UCLA affiliates (VA Greater Los Angeles Healthcare System, Olive View-UCLA Medical Center, Santa Monica-UCLA Medical Center and RAND), in any series (including adjunct and professional research)

As Co-PI (with eligible faculty PI): All personnel who are eligible to serve as PI, community partners, and postdoctoral scholars.

SC CTSI at USC/CHLA
As PI: Faculty associated with USC in any series (tenured/non-tenured, including adjunct and professional research); and CHLA investigators with a faculty-equivalent appointment

As Co-PI (with eligible faculty PI): All personnel who are eligible to serve as PI, community partners, postdoctoral scholars, residents, and clinical fellows

Priority

Proposals that facilitate research across UCLA, USC, CHLA and partner institutions or national CTSA consortium institutions will receive the highest priority.

Application

Format

Arial, 11-point font, half-inch margins on all sides, 8 ½ x 11 standard letter size

Requirements

All proposals must propose a new area of inquiry not currently supported by existing funding. This mechanism will not fund the continuation of an existing project unless the applicant can demonstrate how the proposed project is different from their current efforts.

Applicants should specify how the funding will strengthen the capacity of the CTSI program at their institution to undertake partnered research to pursue the goal of healthy aging in Los Angeles County. The intent is to prepare applicants for future research funding; applicants should specify the extramural funding mechanism being targeted. Acceptable funding mechanisms include but are not limited to NIH R01, R21, R03, PCORI, AHRQ, CDC, and CMS Center for Innovation.

Letter of Intent (LOI)

Co-PIs must submit their NIH biographical sketches along with a one-page LOI by March 10, 2014. Apply here.

The LOI must provide:

  1. Title of research proposal
  2. Names, institutions, telephone numbers and emails of the Co-PIs
  3. Rationale, significance, overall aims, innovation and impact
  4. Extramural multi-PI funding mechanism being targeted
  5. Statement of how the project meets the program intent
  6. CTSI program resources to be utilized at their institution. Examples include Health Services Research (HSR) consultation and biostatistical consultation.
  7. Total budget and source of institutional support (minimum 50% co-funding is required). LOIs will be scored using NIH criteria and local criteria (see Review Criteria). High-scoring LOIs will be invited to submit proposals.

Proposal Components

Narrative
Consists of a 250-word statement on how the project meets the program intent; one page of specific aims; and a research plan of three to five pages. There is no page limit for references.

The Research Plan will be scored based on the following criteria:

  1. Significance
  2. Innovation and impact
  3. Approach to be taken, including, but not confined to, study design; milestones to be achieved during the course of the project (a timeline is strongly recommended)
  4. Community engaged research aims addressed.
    • Promote and sustain bidirectional knowledge-sharing between community and academia.
    • Strengthen community infrastructure for sustainable, partnered research.
    • Drive innovation in community engagement that accelerates the volume and impact of partnered research in diverse communities.
    • Build health services research (HSR) methods into partnerships to accelerate design, production and wide adoption of evidence-based practice and behavior.
  5. Likely impact on the capacity of the CTSI and its partners to develop coordinated activities to implement, assess and disseminate interventions that will promote healthy aging in Los Angeles County
  6. UCLA CTSI and SC CTSI at USC/CHLA resources to be utilized
  7. Targeted, extramural multi-PI grant application with estimated submission and award dates
  8. Investigators and collaborative environment (this section must specifically address interactions between the teams and metrics to be employed to measure the success of the interaction).

Budgets
Budget and budget justification including personnel costs and other costs in NIH format are required. 50% matching is required. In-kind operational support is considered co-funding. Faculty from all partner institutions who receive salary support from the UCLA CTSI or SC CTSI at USC/CHLA should not request any additional salary support in the budget. No indirect costs are allowed.

Biographical Sketches
Compile all biographical sketches after the budget, starting with the Co-PIs followed by additional investigators in alphabetical order (limit 3 pages per biographical sketch).

Review Criteria

LOIs and proposals will be reviewed by a study section comprised of faculty and representatives from all sponsors (LAC DHS and DPH, UCLA CTSI, and SC CTSI at USC/CHLA), using NIH review criteria and the following additional criteria: likelihood of obtaining extramural funding, project sustainability, and alignment with program goals.

Funding Decisions

Allocation of funds will be based on scientific and technical merit, availability of funds, and relevance of the proposed project to program priorities as delineated above.

Submission Dates and Times

RFA release: February 3, 2014
Letter of Intent due: March 10, 2014
Letter of Intent acceptance notification: March 17, 2014
Proposal due: May 15, 2014
Awards announced: June 30, 2014
Earliest start date: July 1, 2014

Additional Information

Awardees must provide their field of specialization, their NIH Commons ID and their IRB and/or IACUC numbers, if applicable, before funds are released. Recipients must credit NCATS and cite grant number UL1TR000124 (UCLA CTSI) and UL1TR000130 (SC CTSI at USC/CHLA) in publications that result from this funding.

Questions

UCLA CTSI
Contact Elvira Liclican, eliclican@mednet.ucla.edu. The CTSI Community Engagement Program will support linkage between LAC DHS and CTSI investigators who are seeking partners.

SC CTSI at USC/CHLA
Please contact the SC CTSI Pilot Funding program team (rd@sc-ctsi.org)

About the Sponsors

LAC Department of Health Services

The Department of Health Services provides acute and rehabilitative patient care, trains physicians and other health care clinicians, and conducts patient care-related research. It provides health services to over 700,000 residents in the Los Angeles County and operates four hospitals, including some of the nation's premiere academic medical centers through their affiliations with the University of Southern California School Of Medicine, UCLA School of Medicine and the Charles R. Drew University of Medicine and Science. In addition, DHS operates six comprehensive health centers and multiple health centers throughout Los Angeles County, many in partnership with private, community-based providers.

LAC Department of Public Health

Los Angeles County Department of Public Health protects health, prevents disease, and promotes health and well being for all persons in Los Angeles County. Our focus is on the Los Angeles County population as a whole, and we conduct our activities through a network of public health professionals throughout the community. Every day, the population of Los Angeles is protected by hundreds of public health measures.

UCLA CTSI

UCLA CTSI is an academic-clinical partnership of UCLA, Cedars-Sinai Medical Center, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center and Charles R. Drew University of Medicine and Science. Its mission is to translate scientific discoveries into health interventions that improve the well-being of Los Angeles residents. To achieve this mission, UCLA CTSI supports pilot studies, trains young researchers, and engages schools and communities in health improvement. It belongs to a national, NIH-supported network of 62 CTSIs.

SC CTSI at USC/CHLA

www.sc-ctsi.org

SC CTSI is part of the 62-member Clinical and Translational Science Award (CTSA) national network funded through the National Center for Advancing Translational Sciences (NCATS) at the National Institute of Health (NIH). Under the mandate of "Translating Science into Solutions for Better Health," SC CTSI provides a wide range of services, funding, and education for researchers and the community, and promotes online collaboration tools such as USC Profiles.

NIDCR KL2 Career Development Award

UCLA CTSI KL2 Program

Dental, Oral and Craniofacial Clinical and Translational Research Career Development Award Request for Applications (RFA)

This is an internal competition to select up to two candidates for final submission of administrative supplements to NIDCR.

Important Dates (Phase 1 - all applicants)

  • Information session: August 18, 2016 12:00-1:00pm Moss Auditorium (A2-342 MDCC)
  • UCLA CTSI Letter of Intent deadline: September 1, 2016 by 5PM Pacific Time (PT)
  • UCLA CTSI Full Application deadline: September 15, 2016 by 5PM PT
  • Supplement application selection date: October 1, 2016

Important Dates (Phase 2 - selected candidates from Phase 1)

  • CTSI Finance Office administrative grant review deadline: October 18, 2016 by 5PM PT
  • NIH/NIDCR submission deadline: November 1, 2016 by 5PM PT
  • Grant start date: February 1, 2017 (expected and contingent on NIDCR administrative supplement)

National Institute of Dental and Craniofacial Research (NIDCR) Career Development Award The UCLA CTSI KL2 Program seeks 1-2 highly qualified junior faculty from one of the four partnered institutions (UCLA, Cedars-Sinai, Charles R. Drew University, and LA BioMed at Harbor-UCLA) to conduct mentored, interdisciplinary, patient-oriented research training to improve dental, oral and craniofacial health.

The objectives of this program are:

  • Conduct translational and clinical investigations to improve dental, oral, and craniofacial health.
  • Support research toward precise classification, prevention, and treatment of dental, oral, and craniofacial health and disease; NIDCR encourages leveraging existing clinical research infrastructure supported by other NIH Institutes and Centers. One important resource is the NIH Clinical and Translational Science Award (CTSA) program, which aims to accelerate translation of laboratory discoveries into treatments for patients, to engage communities in clinical research.
  • Support research, training, and career development programs that value team science, transformative approaches, and diversity at all levels.

Supplement to the National Center for Advancing Translational Sciences (NCATS) CTSA KL2 Program This award will be a supplement to the UCLA KL2 Program, which is designed to support high-impact research careers in translational research. The KL2 program combines formal course work with direct research experience, and an opportunity to pursue additional advanced degrees. All scholars, including those at CTSA partner institutions, have access to CTSA research facilities, which may include:

  • Training courses, seminars and workshops
  • Use of specialized core facilities, laboratories, and databases
  • Access to a team of clinical research mentors
  • Administrative and regulatory support for research protocols
  • Funding for pilot research projects

NIDCR KL2 Supplement Award

This award will be contingent on the successful competition of the NIDCR administrative supplement to the NCATS KL2 Program. If funded, NIDCR KL2 supplement awardees will receive up to 3 years of funding or until receipt of an individual NIH K award (or equivalent grant from the Veterans Administration or foundation), whichever comes first. The award is renewable for up to a total of 3 years. Continued KL2 support in years 2 and 3 will be contingent the awardee's performance during the prior year(s). The following table lists the maximum allowable amounts per year for salary, fringe benefits, research expenses, tuition/career development, travel, and statistical support:

KL2 Scholar Salary (75% effort) $75,000
KL2 Scholar Fringe Benefits (capped at 30%) $22,500
Research Expenses $25,000
Tuition/Career Development $4,000
Travel $2,000
Statistical Support $1,500
MAXIMUM DIRECT COSTS/YEAR $130,000

Eligibility Criteria

  • Possess a research or health-professional doctoral-level degree (e.g., MD, PhD, Pharm D, DDS, DMD) and be a junior faculty member at one of the four UCLA CTSI partnered institutions in any series at or above the clinical instructor level by the grant start date.
  • U.S. citizen or permanent resident at time of application. Individuals on temporary or student visas are not eligible.
  • Commit a minimum of 9-person months (75% of full-time professional effort) to conduct dental, oral or craniofacial translational research. The remaining effort may be devoted to clinical, teaching, or other research pursuits and activities consistent with the objectives of the KL2 research career development program.
  • Former PD/PIs on NIH research project (R01), program project (P01), center grants, FIRST Awards (R29), sub-projects of program project (P01) or center grants are not eligible. Former PD/PIs on NIH career development awards (K–awards), or the equivalent, are not eligible, EXCEPT for Dentists who were awarded an NIDCR K08 to support dissertation research that resulted in a PhD, who remain eligible for KL2 support. Former PDs/PIs of an NIH Small Grant (R03), Exploratory/Developmental Grant (R21), Dissertation Award (R36), or SBIR/STTR (R41, R42, R43, R44) remain eligible.
  • May not have a pending application for any other PHS mentored career development award (e.g., K08, K23) that duplicates any of the provisions of the KL2 administrative supplement.

UCLA CTSI Letter of Intent & Full Application Submission Information

  • Letters of Intent will be accepted through 5:00PM PT on September 1, 2016. These letters are optional. However, applicants are strongly encouraged to submit a Letter of Intent to help the CTSI identify the best reviewers and enhance the review process of the application.
  • Full Applications are due by 5:00PM PT on September 15, 2016.
  • The links to the submission website for the Letter of Intent and Full Application will be available at: http://www.ctsi.ucla.edu/education/pages/kprogram and see "Request for Applications (RFA)" tab.

The Letter of Intent must include:

  • The specific areas of expertise that are needed to review the proposal.
  • NIH-formatted Biosketch of the scholar (must be in the new format).
  • Specific aims for the proposed project (1 page maximum)
  • List of mentors (name, title, institution, department) for the career development.

To be considered, the Full Application packet must include the items below. Please refer to the NIH Application Guide for general instructions.

  1. Project Summary/Abstract (30 lines of text maximum).
  2. NIDCR KL2 Scholar NIH-formatted Biosketch (must be in the new format). The personal statement of the scholar's biographical sketch should include a description of his/her research objectives and career goals, and why their experience and qualifications make them particularly well-suited to receive an NIDCR KL2 supplement award. Relevant factors include previous training and research accomplishments in dental, oral and craniofacial research and any source(s)
  3. NIDCR KL2 Scholar NIH-formatted Other Support Pages with current, past and pending grants. Please see the NIH policy concerning concurrent support from a K award and a research grant.
  4. Program Plan (11 pages maximum). The proposed research career development plan should align with the mission of the NIDCR and the KL2 program. The research experience should challenge the scholar's scientific curiosity while introducing a creative, novel, and clinically significant approach to dental, oral or craniofacial research. The plan should augment the scholar's research development yet be individualized to their scientific discipline and expertise. Describe key activities during the supplement, including mentored team science activities, didactic coursework, and technical training to enhance skills and proficiency in conducting translational research. Address specific training in dental, oral, or craniofacial clinical disease and describe how it will be incorporated into the research career development plan. Present a timeline for activities and potential publications and grant applications for independent research support. The application must also address the following:
    • Program Faculty: Provide information about the program faculty who will be involved in the scholar's activities, including the complementary expertise and experiences, active research and other scholarly activities in which the faculty are engaged, as well as experience mentoring individuals at the proposed career stage. If any co-mentor is not located at the sponsoring institution, describe the frequency and type of communication that will be used to engage the scholar.
    • Proposed Research Career Development Plan: The proposed research career development plan should align with the mission of the NIDCR and the mission of the UCLA CTSI KL2 program, which is to develop independent translational scientists. The research experience should challenge the scholar's scientific curiosity while introducing a creative, novel, and clinically significant approach to dental, oral or craniofacial research. The plan should augment the scholar's research development yet be individualized to their scientific discipline and expertise. Describe key activities during the supplement, including mentored team science activities, didactic coursework, and technical training to enhance skills and proficiency in conducting translational research. Address specific training in dental, oral, or craniofacial clinical disease and describe how it will be incorporated into the research career development plan. Present a timeline for activities, such as potential publications and grant applications for independent research support. Format for this career development plan should include a candidate's statement, educational/training plan and research plan similar to a traditional NIH career development award proposal.
    • Institutional Environment and Commitment to Training: Include a signed letter, on institutional letterhead, that describes the applicant institution's commitment to the planned KL2 supplement program. The letter should provide assurance that the scholar will be able to devote a minimum of 9 person-months (75% of full-time professional effort) to their KL2 research career development program. The remaining effort should be devoted to activities related to the development of the scholar's career as an independent investigator or clinician- scientist, e.g., clinic responsibilities, teaching and administration, and/or additional research activities. Suggested 1 page in length and is included in the 11-page maximum of the program plan.
  5. Training in the Responsible Conduct of Research (1 page maximum).
  6. Letters of Support from the Primary Mentor and Co-mentors(s) (6 pages maximum) detailing the scholar's capabilities, accomplishments, and commitment to developing an academic career in translational research; a preliminary research training plan, including area of focus and specific projects; potential associate mentors to enhance training expertise; additional plans for the scholar's professional development; departmental support for the scholar's future academic career development.
  7. Letters of Support from Collaborators, Contributors, and Consultants (6 pages maximum). Attach appropriate letters from all individuals confirming their roles in the proposed KL2 supplement program.
  8. Mentoring Team NIH-formatted Biosketches of each of the individuals who will comprise the scholar's mentoring team (must be in the new format). The personal statement of the individuals who will serve on the scholar's mentoring team should include a description of his/her specific role in mentoring the scholar, how the mentoring will occur (e.g., frequency and mode), and how the scholar's progress will be monitored during the supplement award period.
  9. NIH-formatted Detailed Budget and Budget Justification for each year of the three years of support. Please use a separate Form Page 4 for the detailed budget for each year.
  10. Data and Safety Monitoring Plan. Please visit http://www.nidcr.nih.gov/Research/ToolsforResearchers/Toolkit/DataandSafetyMonitoring.htm for more details.
  11. Human Subjects. Complete this section if the scholar will design and conduct their own independent human subjects research and indicate that the proposed research experience was approved by the human subjects Institutional Review Board (IRB) at the grantee institution. Adherence to the NIH policy for including women and minorities in clinical studies must also be ensured, if additional human subjects' involvement is planned for the supplement component. If available, also include a copy of the IRB approval notice.
  12. Vertebrate Animals. Complete this section if the scholar will design and conduct their own independent vertebrate animal research and indicate that the proposed research experience was approved by the Institutional Animal Care and Use Committee (IACUC) at the grantee institution. If available, also include a copy of the IACUC approval notice.
  13. Facilities and Other Resources. Describe how the scientific environment in which the research will be done contributes to the probability of the scholar's success (e.g., institutional support, physical resources, and intellectual rapport).
  14. Bibliography & References Cited (optional).
  15. Appendix (optional).

NIH Fonts and Margins Tips

  • Use an Arial, Helvetica, Palatino Linotype, or Georgia typeface, a black font color, and a font size of 11 points or larger. (A Symbol font may be used to insert Greek letters or special characters; the font size requirement still applies.)
  • Type density, including characters and spaces, must be no more than 15 characters per inch. Type may be no more than six lines per inch. Use standard paper size (8 1/2 x 11"). Use at least one-half inch margins (top, bottom, left, and right) for all pages. No information should appear in the margins.

Proposal enhancement: Selected KL2 applications will be discussed with the UCLA CTSI KL2 program director, Dr. Mitchell Wong in the first week of October based on the review critiques aiming to enhance the competitiveness of the supplement application to NIDCR.

Questions about the RFA can be directed to Lisa Chan at KL2@ctsi.ucla.edu.

Older Americans Independence Center Career Development Award

UCLA Claude D. Pepper Older Americans Independence Center (OAIC) and
UCLA Clinical and Translational Science Institute (CTSI)
Career Development Award (CDA)

Request for Letters of Intent

June 13, 2014

We are requesting letters of intent (LOI) that will provide up to three years of funding for a junior faculty member who is conducting aging-related research consistent with the UCLA OAIC’s theme of “Preventing Disease and Disability in Vulnerable Populations: A Translational Approach”. We define vulnerable populations as 1) underserved (i.e., low income, uninsured, and minorities) or 2) at increased risk of losing independence because of chronic diseases or conditions, advanced age, or functional impairment. We define translational as overcoming two barriers to effective research. The first is the inability to transfer new understandings of disease mechanisms gained in the laboratory into new diagnostic, therapeutic, and preventive care. The second is the inability to get results from clinical studies into everyday clinical practice and health decision making. In studying vulnerable populations, the UCLA OAIC emphasizes research that extends across the full spectrum of translational research. Within this theme, an important focus of the UCLA OAIC is on understanding the role of inflammation in disease and disability.

The UCLA OAIC addresses health disparities that vulnerable older persons face because of 1) inadequate understanding of contributors (e.g., socioeconomic status, inflammation) to health and specific illnesses (e.g., HIV, sleep disorders, depression), 2) lack of effective preventive or therapeutic approaches (biomedical and behavioral), or 3) inadequate ability to get needed treatment to vulnerable older populations (e.g., cultural barriers, ineffective health systems). It also helps overcome the barriers between the promise of basic science research and the delivery of better health.

The awardee is expected to devote at least 75% of his/her time to research. The total amount of the award is $75,000 of which $25,000 is provided by the OAIC, $25,000 is provided by CTSI, and $25,000 must be provided by the awardee’s Department, Division or Mentor. This amount of support is guaranteed for at least one year. Subsequent years of funding will depend on the availability of funds and the renewal of UCLA CTSI (in 2015), and UCLA OAIC (in 2016).

Candidates for this program must be UCLA M.D. or Ph.D. faculty in their first to fifth years, whose aim is to become an independent investigator in aging research, and working with a UCLA senior faculty mentor.

Selection criteria include:

  • Strong commitment to an academic career in aging research
  • Skills and interests compatible with a training program in an interdisciplinary, translational research approach with special emphasis on preventing disease and disability in vulnerable aging populations
  • Research experience and productivity to date
  • Willingness to develop and adhere to specific learning and research goals and timelines including participation in OAIC training activities
  • Proposed research and training plan and the qualifications and commitment of the primary mentor
  • Proposed and ongoing research that addresses the OAIC theme and has compelling significance, innovation and impact
  • Strong support letter from the proposed primary mentor
  • Commitment by the sponsoring department, division, or mentor to provide matching financial support for the recipient ($25,000/year) and guarantee 75% protected time for research and career development activities

APPLICATION PROCESS

  1. Submit an initial application packet via e-mail for review by the OAIC Executive Committee. All initial application packet submissions must be received by 8:00A.M. PST on Wednesday, July 2, 2014 (see contact information below).
  2. The initial application packet must include:
    1. A letter of intent (up to 2 pages) from the candidate indicating her/his research and training goals for the CDA program, how these goals align with the OAIC center theme, what OAIC resource cores (i.e., RRC, IBC, ACEC, ROC) they envision using, and future career plans, and how this award would advance their careers in academic aging-related research.
    2. A letter of support (up to 3 pages) from the candidate's potential Primary Mentor detailing the candidate's capabilities, accomplishments and commitment to an academic career in aging; the proposed research and training plan, potential associate mentors; departmental support for the candidate's future academic career development, and a commitment to provide matching support and release time.
    3. CVs of potential CDA candidate and proposed Primary Mentor
  3. We will review the initial application packets and select candidates to be scheduled for an interview after July 11 with 2-3 OAIC Executive Committee members.
  4. Selected candidates will be asked to work with their mentors to prepare an application (up to 10 pages) that details the candidate's research and training plans, including specific learning goals, research objectives and timelines.
  5. The candidates' applications will be due on Monday, August 25 and reviewed by the UCLA OAIC Executive Committee and the External Selection Panel. The candidate selected will be notified by September 8 and funding for the selected candidate will begin immediately.

The initial application packet should be e-mailed to:
Lucio Arruda
UCLA Division of Geriatrics
larruda@mednet.ucla.edu
(310) 825-8253

For more information on the OAIC mission and services, please click here.

For more information on the CTSI mission, programs and services, please click here.

Older Americans Rapid Pilot Grants Program

UCLA Older Americans Independence Center (OAIC) and UCLA Clinical and Translational Science Institute (CTSI)

January 7, 2016 Announcement

The UCLA OAIC and the UCLA CTSI are soliciting applications for the Rapid Pilot Grants Program for aging-related basic, clinical and health services research. Award size will range from $1,000 to $10,000, dependent on scope of work.

A "rolling applications process" will be used. Applications will be accepted until the allocated funds for this program have been spent.

Eligibility criteria:

  • Junior Investigators: The PI must be a UCLA junior faculty member or advanced trainee at the post-doctoral level (pre-doctoral students are not eligible) with an identified and committed UCLA faculty mentor (the mentor will be the PI of record and responsible for the project).
  • Senior Investigators: The PI must be a UCLA senior faculty member who wishes to use this pilot funding to create a new area of emphasis in her/his work that is aging-related.
  • Because this award will provide limited, targeted support for a discrete need, applicants must provide tangible evidence that the infrastructural environment to conduct the research is adequate.

Award criteria:

  • Proposed work must be responsive to the UCLA OAIC research theme (see below). Applications that are not directly responsive to the mission will not be reviewed.
  • If the investigator is junior, the work must advance their independent research goals.
  • Results must have high likelihood of resulting in preliminary data for a larger research grant application and/or first-authored publication by the junior investigator.
  • Applications that are aimed at collecting additional preliminary data in response to a recent, favorably scored, but not funded grant application are of particular interest.
  • Also of interest are proposals that will used data from existing cross-sectional and longitudinal studies of aging and age-related disorders, to understand factors that exacerbate and mitigate inflammation in aging.
  • If the rapid pilot entails the study of human or animal subjects, an active IRB or IACUC approval must be in place at the time of the submission of the pilot application.
  • Requested funding amount must be appropriate for the proposed work.
  • Funds must be expended by June 30, 2016.

UCLA Claude D. Pepper Older Americans Independence Center Theme

The theme of the UCLA OAIC is “Inflammation, Aging, and Independence.”

The UCLA OAIC will support both observational and interventional research on factors that contribute to increased inflammation in aging and its consequences to:
  1. Determine how inflammatory markers change with normal aging and with specific diseases and how these changes in inflammation affect diseases and outcomes related to independence;
  2. Link inflammatory markers to genetic and epigenetic profiles; and
  3. Develop and test interventions to reduce inflammatory burden and determine the effects of these interventions on health and functional outcomes.
The relation between inflammation and aging is complex. “Usual” aging is associated with rising markers of inflammation. Indeed, the term “inflammaging” has been coined to describe the low-grade, chronic, systemic inflammation in aging, in the absence of overt infection (“sterile” inflammation). Many other contributing factors affect inflammation including specific diseases as well as social and lifestyle factors. Some (e.g., sedentary lifestyle, poor sleep) exacerbate inflammation whereas others (e.g., participation in social and physical activities) mitigate inflammation. Conversely, exposure to higher levels of inflammation may contribute to accelerated aging and the development or progression of common diseases of aging (e.g., coronary artery disease, diabetes) and adverse outcomes (e.g., disability, loss of independence, and premature mortality).

The pathways that control age-related inflammation across multiple systems, the interactions of risk factors, and how these increase adverse outcomes are poorly understood. Even less is known about the pathways by which these factors alter the signaling and transcriptional pathways that drive chronic inflammation, which is critical for the development of precision-medicine interventions that selectively target risk factors based on individuals’ distinct profiles.

The Center stimulates scientific discovery through 4 Resource Cores (Recruitment and Retention, Research Operations, Analysis and Cost-effectiveness, and Inflammatory Biology), a Pilot and Exploratory Studies Core, a Research Career Development Core, and a Leadership/Administrative Core.

For investigators interested in doing secondary data analysis, we suggest you visit http://geronet.ucla.edu/research/dap to learn about available data sets that contain inflammatory biomarkers.

RAPID GRANT APPLICATION PROCESS

Submit an application packet via e-mail to Lucio Arruda. Note that awards will be made on an ongoing basis until program funds are exhausted. Interested applicants should contact Lucio Arruda before submitting to ensure that funds are still available and to obtain information about rolling submission due dates. (Please see contact information below).

The application packet must include the following:

A 3-page application, single spaced using Arial font 11-point typeface, with one-inch margins, which includes the following:

  1. Relevance: explicit statement about responsiveness of the research to OAIC theme
  2. Primary research questions and hypotheses
  3. Brief background and significance
  4. Brief methods including discussion of sample size (applications without a justification of sample size will not be reviewed)
  5. Timeline (note expenditure deadline)
  6. Specific statement about how data will result in one or more of the following: a revised grant application; a new grant application; a manuscript
  7. Proposed use of pilot funding (~5 sentences describing the amount of funding requested, the exact intended use of the funds, and why this funding is instrumental to the success of the project)

Also include:

  1. Biosketches and the NIH Commons username of all investigators and junior faculty mentor(s)
  2. IRB or Animal Use approval numbers as appropriate (because of the rapid turnaround time, proposals that require IRB or Animal Use approval must have this approval at the time of application).
  3. For Junior Faculty Applicants: A mentor’s letter that includes explicit description of the infrastructural support that will be available to the pilot project and the nature and amount of mentorship that will be provided.
  4. For Senior Faculty Applicants: A cover letter that describes how the pilot funding will be used to newly bring an aging focus to your area of research.
  5. For applications that are attempting to collect additional preliminary data in response to recent grant application reviews: include a complete copy of the grant application review and specifically identify the critique that will be addressed by the proposed work.

Funding decisions will be make within 8 weeks of receipt. Successful applicants may be asked to attend a team science training and must agree to submit progress reports, present their findings at local Pepper Center meetings, and cite the UCLA Pepper Center and the UCLA CTSI on all publications related to the support.

The application packet should be e-mailed to the attention of:
Lucio Arruda
UCLA Division of Geriatrics
larruda@mednet.ucla.edu
310-825-8253

Co-Sponsorship

The UCLA Clinical and Translational Science Institute (CTSI)

The UCLA Clinical and Translational Science Institute (UCLA CTSI) is co-sponsoring the UCLA-OAIC rapid pilot program.  A brief description of the UCLA-CTSI follows.  Please note that the successful UCLA OAIC-CTSI rapid pilot applicant must be responsive to the UCLA OAIC research mission, described above. 

The UCLA Clinical and Translational Science Institute (UCLA CTSI) provides the infrastructure to bring UCLA innovations and resources to bear on the greatest health needs of Los Angeles and the nation. It is a dynamic partnership among UCLA Westwood, Charles Drew University of Medicine and Science, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, the Burns and Allen Research Institute at Cedars-Sinai Medical Center and our Los Angeles community. It is one of more than 60 NIH-funded CTSIs nationwide.

Pathfinder Award

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The UCLA Clinical and Translation Science Institute is accepting applications for Pathfinder Awards. This opportunity will support the study of (1) operational enhancements or innovations that build on existing CTSI infrastructure and (2) novel methods or technologies to enhance the development, testing or implementation of therapeutics or diagnostics for human disease.

Deadlines
Apr. 15, 2015: Opportunity opens, 3 PM
May 15, 2015: Submission deadline, 5 PM
July 1, 2015: Earliest start date

Purpose
The UCLA CTSI provides the infrastructure to support research that translates scientific discoveries to improve health and health care. Pathfinder grants test solutions to operational or scientific roadblocks that slow the pace of translation. Examples of proposals eligible for this opportunity include development and testing of software (e.g., research networking, survey tools, evaluation and tracking tools); user-friendly forms (e.g., IRB applications, informed consent documents); Web-based modules based on CTSI courses; data management for the research community; recruitment tools, new approaches to services; and novel methods or technologies to enhance the conduct of research (e.g., , informatics, phenotyping,  novel study design,).  Proposed solutions must be generalizable to the 62 institutions that belong to the NIH-supported Clinical and Translational Science Award (CTSA) consortium. Applications from multidisciplinary teams are especially welcome.

Award
This funding opportunity will provide up to four, one-year awards of up to $50,000 each.  Awards are expected to lead to submission of an application for extramural funding.  Proposals should not duplicate existing core infrastructure on CTSI campuses or simply extend an existing research project to propose a solution that is not generalizable or scalable. Proposals that address three CTSI priorities – community engagement, MULTIDISCIPLINARY team science, RESEARCH ACCELERATION multidisciplinary research – will receive highest priority. Proposals are not expected to address all three priorities. A brief consultation in the conduct of community-engaged research is required of all awardees and must be completed before funds are released. Awardees are required to participate in the Team Science Initiative, which involves a team-training workshop. Semiannual and end-of-project reports are required. Carryforward of funds is not allowed.

Eligibility

Faculty associated with UCLA and UCLA CTSI institutional partners (Cedars-Sinai Medical Center, Charles R. Drew University of Medicine and Science and Los Angeles Biomedical Institute at Harbor-UCLA Medical Center), and UCLA affiliates (VA Greater Los Angeles Healthcare System, Olive View-UCLA Medical Center, Santa Monica-UCLA Medical Center and RAND), in any series (including adjunct and professional research)

Application Information

Application components and page limits

  • Title of research proposal
  • Names, institutions, telephone numbers and emails of PI, Multiple PIs
  • IRB, IACUC, Stem Cell information, if applicable
  • Lay summary: 350 words (text box)
  • Specific Aims and Research Strategy:  3 pages total for specific aims and research strategy; no limit for references. PDF/Word upload.
  • Timeline, milestones and evaluation metrics:  1 page, PDF/Word upload
  • Budget:  Please complete and upload PHS 398 Form Pg. 4 "Detailed Budget for Initial Period” with budget justification
  • Biographical sketches:  Provide for PI, Multiple PI and Key Personnel. Use the PHS 398 biosketch form. NIH page limits apply. PDF/Word  upload.
  • Letters of Support: PDF/Word upload

Minimum technical specifications
Arial, 11-point, half-inch margins, 8.5x11 documents only.

Scoring and selection
Applications will be reviewed by study sections of subject experts from the UCLA CTSI. Ad hoc experts from external organizations will be recruited if needed. NIH review criteria and scoring will be used. NIH policies and conflict-of-interest rules apply. Allocation of funds will be based on scientific and technical merit, availability of funds, and relevance of the proposed project to CTSI priorities as delineated above.

Additional review criteria

  • Does the proposal address a significant roadblock to translation?
  • Is the proposed solution generalizable to the national network of 62 CTSA institutions?
  • Is it feasible within the time allowed and the budget proposed?
  • Does the proposal include a dissemination plan?
  • Is the team multidisciplinary?
  • Does the proposal involve community?
  • Will the proposed project, if successful, accelerate translation?

How to Apply

Application

Contact

RFA questions: Denise Gellene, Director of Scientific Communications and Research Development, dgellene@mednet.ucal.edu
Technical support for online application: Maryam Ariannejad, MArian@mednet.ucla.edu

About the UCLA CTSI
UCLA CTSI is an academic-community partnership to accelerate scientific discoveries and clinical breakthroughs to improve health and health care in Los Angeles, the most populous county, and among the most diverse, in the United States. Its mission is to create a borderless clinical and translational research institute that brings UCLA resources and innovations to bear on the greatest health needs of Los Angeles. It is one of 62 CTSAs supported by the National Center for Advancing Translational Sciences (NCATS) at NIH.
More information about the UCLA CTSI can be found at www.ctsi.ucla.edu. Information about the national CTSA consortium can be found here.

RMCAR-CHIME / CTSI - Pilot Award

UCLA/Charles R. Drew University - Resource Centers for Minority Aging Research 
"Center for Health Improvement of Minority Elderly" (RCMAR/CHIME) 
and UCLA Clinical and Translational Science Institute (CTSI): 
Pilot Project Award 2017-2018

Applications are being accepted for one-year Pilot-Project Awards of up to $40,000 for the project period 07/01/2017 - 06/30/2018

Who Should Apply: Applications are being accepted from minority junior- and mid-level faculty and post-doctoral researchers. Applicants are required to have an academic appointment between 07/01/2017 - 6/30/2018 at UCLA or at another academic institution/organization in the greater Los Angeles area. Applicants that are funded will conduct a pilot research project that focuses on minority elderly populations.

Funding Amount Available: Three (3) one-year pilot project awards are available. The maximum funding available per pilot project is $40,000: up to $20,000 from the RCMAR/CHIME (NIH/NIA Grant #P30-AG021684) and up to $20,000 from the CTSI (NIH/NCATS Grant #UL1TR001881).

Focus of Pilot Projects: Support will be given to pilot research projects that are consistent with the goal of the RCMAR/CHIME, which is: to provide research training and mentoring to minority junior- and mid-level faculty so they can advance their academic careers by conducting research that contributes to the reduction of health disparities affecting minority elders. Typically, pilot projects that are funded involve primary data collection and/or secondary data analysis and aim to address disparities in the healthcare of minority elders. Ideally, these pilot projects also demonstrate effective inter-institutional and/or academic-community partnerships. In addition, the proposed pilot project should lead to publication of at least one (1) first-authored, peer-reviewed manuscript plus subsequent funding from the National Institutes of Health (NIH), particularly the National Institute on Aging (NIA).

Note: We do not fund pilot projects focused on basic-science or clinical research (a branch of medical science that determines the safety and effectiveness of medications, devices, diagnostic products and treatment regimens intended for human use).

Application Timeline:

  1. By 12pm noon Friday, January 13, 2017, applicants must submit an online application on the RCMAR/CHIME website - http://chime.med.ucla.edu/apply - and upload the required supporting documents.
  2. By approximately Wednesday, February 1, 2017, candidates will be notified if they have been selected to prepare and submit proposals and supporting documents.
  3. By approximately Wednesday, March 1, 2017, selected candidates must submit proposals with supporting documents including a six-page, single-spaced research plan and detailed budgets and other requested documents.
  4. Candidates whose proposals are selected for funding will be notified as soon as possible. The full proposals and supporting documents will be forwarded to the NIH/NIA for final approval. The award will then be dispersed after July 1st, 2017.

Application Submission and Required Documents: Applicants must complete and submit the following required documents by 12pm noon, Friday, January 13, 2017:

  1. Complete the required online application form on the RCMAR/CHIME website http://chime.med.ucla.edu/apply and
  2. Upload the following required documents as Microsoft Word files on the RCMAR/CHIME website http://chime.med.ucla.edu/apply.
    1. A synopsis describing the proposed pilot project. The synopsis must be single-spaced in Arial font with 11-point typeface, one-inch margins, on 8.5"x11"-size page, limited to a maximum of two (2) pages and must include:
      1. Title of project;
      2. Description of proposed pilot project including brief description of project design, and data to be collected or used in the pilot project;
      3. A specific statement about how the proposed pilot project is related to the RCMAR goal of supporting minority junior- and mid-level faculty and post-doctoral fellows who can advance their academic and research careers by conducting a pilot research project that contributes to the reduction of health disparities affecting minority elders;
      4. A brief timeline that documents the feasibility of completing the pilot project in one year;
      5. A specific statement about how this pilot project will inform the applicant's future research and how it will lead to larger funding by the National Institutes of Health (NIH) or another agency;
      6. A description of the applicant and their role on the project; and
      7. Proposed mentor(s) and a statement about their involvement and the role they will play in conducting this pilot project.
    2. Applicant's current Curriculum Vitae (CV).
    3. Applicant's current NIH Biosketch in the new format.
    4. Mentor's (s') current NIH Biosketch in the new format.
    5. Institutional Letter of Support: You must submit an institutional letter of support from either your department chair or division chief confirming that you will have a junior- or mid-level faculty appointment between 07/01/2017 and 06/30/2018 and adequate "protected time" during that time period in which to conduct your proposed pilot project.

    Please contact Carole A. Nagy or Art Gongora at rcmarchime@mednet.ucla.edu with any questions.

    For more information about the RCMAR/CHIME and the UCLA CTSI visit http://chime.med.ucla.edu/ and http://www.ctsi.ucla.edu/.

Team Science - Basic and Clinical Approaches to HIV/AIDS

HIV Extinction Project Funding Opportunity
Multi-Disciplinary Collaboration

The UCLA Center for AIDS Research (CFAR), AIDS Institute and the UCLA Clinical and Translational Science Institute (CTSI) are accepting Letters of Intent for seed grant proposals to encourage multidisciplinary collaborations in HIV Cure research. Applicants are invited to submit proposals describing innovative approaches to ultimately cure HIV disease. The goal of these grants is to encourage collaborations between multiple disciplines in order to facilitate development of preliminary data for future submissions of program projects or equivalent. Collaboration with CTSI institutions (Cedars- Sinai, Charles R. Drew University, LA BioMed/Harbor-UCLA and UCLA) is encouraged.

Funding level: $100,000 (a total of $200,000 is available for 2 grants)

Deadline for receipt of Letters of Intent: Friday December 5, 2014

Applicants whose Letters of Intent are favorably reviewed will be invited to submit a formal proposal. Formal proposals will then be due by Friday January 30, 2015.

The project period will be two years, with the earliest start date of March 16, 2015.

Investigator eligibility
Investigators applying for seed grants must be:

  • Faculty (Adjunct, In-residence, or Regular Professor series, Assistant Research Biologists Step 2 and higher, or Clinical Instructor series and higher), at UCLA, an affiliated institution, or collaborating community-based organization.

Funding criteria

  • Established projects will not be considered.
  • Multi-disciplinary projects must involve novel collaborations involving two or more faculty members. The application must demonstrate that:
    • Each party's contribution to the collaboration comes from expertise in distinct disciplines without overlapping areas of research or technical know-how.
    • A substantial contribution is made by each party in the collaboration (for example, simple provision of reagents or advice by one party would not qualify)
    • The work could not be performed effectively without the collaboration.
  • Applicants should describe all preliminary data supporting the project.
  • Proposals should outline clearly how research funded by the seed grant can be translated into a larger collaborative project, such as a program project or equivalent.
  • Only US-based projects will be considered.
  • Although IRB and/or IACUC approval is not required prior to the submission of the application, release of funding will be contingent on receipt of IRB and/or IACUC approval notice(s) listing the UCLA CTSI grant number UL1TR000124 and the UCLA CFAR grant number 5P30 AI028697, as funding sources for the proposed project.
  • Please note that human subjects younger than 21 are classified as children (per NIH guidelines) and additional approvals such as informed consent will be required before funding can be released.
  • No indirect costs may be included.
  • Grants will be reviewed by a peer-review committee.
  • Progress reports and end of project reports will be required.

CFAR core facilities are available, on a recharge basis, in these areas: virology, cytometry, humanized mice, gene and cellular therapy, biostatistics, mucosal immunology, and clinical research facilitation (IRB and patient registry). For contact information, please see http://aidsinstitute.ucla.edu/site.cfm?id=32

Instructions for letters of intent
Letters of intent must be no longer than 2 pages, and must include the following:

  • Your name, degrees, and full contact information (email, phone, mailing address)
  • Brief summary of the proposed research project
  • Roles of the collaborating investigators
  • Brief summary of your experience conducting similar research
  • Total amount of funding requested
  • How this award would facilitate future submissions of program projects or similar collaborative grants.
  • Must also include NIH biosketch (does not count towards the 2 page limit)

Letters of intent must be received no later than 4:00 pm on Friday December 5, 2014. They can be sent via post or email to: UCLA AIDS Institute, 10940 Wilshire Blvd., Ste 960, Los Angeles, CA 90024, aidsinst@ucla.edu

Instructions for formal proposals will then be forwarded to applicants whose letters of intent are approved. Formal proposals will then be due no later than 4:00pm on Friday January 30, 2015.

Successful applicant PIs must provide their NIH Commons ID number. During the award period and for up to five years post-award, awardees must provide the following information to the UCLA CTSI by November 30 of each year: (1) all publications that resulted from CTSI-supported research with PubMed ID, and (2) all PHS and non-PHS federal support that contributed to or resulted from the CTSI-supported research. Questions about the UCLA CTSI can be directed to the CTSI Office of Investigator Services at 310-794- CTSI.

Questions about eligibility, letters of intent, or formal proposals can be directed to Jina Lee, aidsinst@ucla.edu, 310-794-5335

Team Science - Cardiac Fibrosis: Basic Biology and Translation to Human Heart Disease

Understanding Cardiac Fibrosis:
Basic Biology and Translation to Human Heart Disease

General Information:
The UCLA CTSI is pleased to announce an RFA for combined basic and clinical research in cardiac fibrosis. The awards are intended to catalyze extramural funding for innovative, collaborative and translational research at UCLA. This RFA will fund one or more project(s) that demonstrate collaborative and innovative research, and that will increase competiveness for NIH awards for translational research.

Proposal Submission Date and Time:
The proposal must be submitted by close of business on Friday, February 20, 2015 through online submission at http://rfp.ctsi.ucla.edu/Awards/cf

Projected Period Dates:
The award period will be for two years and the maximum budget is $200,000. Funding will start on June 1, 2015 upon approval from the CTSI, and after all required documents are received. Prior to transfer of funds, appropriate IRB/ARC approvals must be in place.

How to Apply:
Online via CTSI website at http://www.ctsi.ucla.edu or directly through the Cardiac Fibrosis link at http://rfp.ctsi.ucla.edu/Awards/cf

Grant Description:
Heart disease is the leading cause of mortality and morbidity in the United States. The heart exhibits a poor ability to regenerate after injury, and heals primarily via a fibrotic response characterized by replacement of lost muscle by scar tissue. Cardiac fibrosis is currently an irreversible condition that contributes not only to the development of systolic and diastolic heart failure, but importantly, to life-threatening electrical instability as well. Despite the clinical importance of cardiac fibrosis, no therapies are available to treat the process of fibrosis. The genetic and epigenetic regulation of fibrosis after heart injury remains unclear.

Proposals should address all of the following:

  • Systematic discovery of genes and epigenetic changes that contribute to fibrosis in the adult heart after acute or chronic injury
  • Identification of novel pharmacological targets for manipulating scars during and after the development of fibrosis
  • Integrated imaging and electrical mapping techniques for guiding direct interventions in cardiac scars in large animals and humans

Who May Apply:
Each applicant team must consist of at least three faculty from UCLA and no faculty can be a member of two teams.

Review Criteria:

  • Scientific excellence and potential scientific and clinical impact
  • Record of accomplishments of the team members
  • Potential of the project to lead to a multi-investigator grant
  • Extent to which the team includes researchers with diverse expertise, including clinical participants

Submission Guidelines:
The application should be prepared according to the instructions for an NIH R21 application. Specifically, the application should include a one-page Specific Aims document, a six-page Research Strategies document that includes Significance, Innovation, and Approach sections, and a Literature Cited section. These scientific sections should be accompanied by an NIH-style itemized budget and budget justification. No indirect costs are allowed. Biosketches for each key participant and a statement on plans to fund the project beyond the grant period (limited to 2,000 characters) are also required. Copies of IRB and ARC approvals or status of applications should also be included.

If awarded, CTSI will specify the following requirements:

  • The continued funding of the CTSI grants is dependent on the program’s success. For this reason, it is important that any publications (journal articles, websites, papers, testimonials, etc.) resulting in whole or in part from this project should acknowledge support from both by including the following statement: "This project received support from both the NIH/NCATS UCLA CTSI Grant Number UL1TR000124."
  • Please notify the CTSI of any subsequent extramural grant support obtained that is relevant to this grant funding.
  • Prior to transfer of these funds, appropriate IRB/ARC approvals must be in place. In accordance with NIH policy, please amend your relevant IRB and/or ARC protocol to disclose funding support from the UCLA CTSI Grant number UL1TR00124.
  • Copies of your IRB, and/or ARC approval will be required.
  • In the section on plans for supporting the project beyond the grant period, the applicants must specify the exact extramural funding mechanism being targeted and application deadline (e.g., NHLBI P01 for June 1, 2014).
  • Applicants must identify specific CTSI resources to be utilized and explain how the proposed research is translational.
  • Progress reports and end‐of‐project reports will be required; templates will be provided. Presentations of posters at CTSI‐sponsored meetings are encouraged.

Questions:
Please send questions related for RFA to Dion Baybridge at DBaybridge@mednet.ucla.edu

Team Science - Cardiovascular Theme Team Science Award

CTSI/Cardiovascular Theme Team Science Award

Letter of Intent Due Date: October 9, 2015, 5pm PST (Finalists for full applications notified by November 6th)

Application Due Date: January 29, 2016 5pm PST

Funding Period: April 4, 2016-April 3, 2017

Funding Amount: Up to $100,000/year for 1 year to support salary , benefits & research supplies

The UCLA Clinical and Translational Science Institute (CTSI) and the UCLA Cardiovascular Theme are pleased to announce the CTSI/Cardiovascular Theme Team Science, Award for research teams from UCLA and CTSI partner institutions (Cedars-Sinai, Charles Drew University, LA-Biomed) and CTSI-affiliated institutions (RAND, Olive View UCLA Medical Center, Santa Monica UCLA Medical Center, VA Greater Los Angeles Healthcare System) to conduct novel, multidisciplinary, team-oriented and high-impact research in diagnosis and treatment of cardiovascular diseases. The team-oriented approach is essential to the feasibility and potential success of theproposal. Applicants are encouraged to follow NIH-style grant guidelines and scientific review criteria for their research proposals. Teams are expected to generate data that will lead not only to academic products but also to the submission of highly competitive U-level, multi-PI RO1 or P01-level proposals to public agencies or private foundations.

The CTSI/Cardiovascular Theme Team Science Award will support two initial cardiovascular research teams, intended to be broadly and inclusively interpreted, to help investigators develop forums for this multidisciplinary work.

Specific Requirements:

  • The research team should propose development of expanding collaboration in research toward improving cardiovascular health.
  • The research team must be led by a Principal Investigator (PI) or multi-PIs who are full-time faculty members at UCLA or at an affiliate or CTSI-partner institution with a proven track record of high-impact research, productivity and leadership in the research area.
  • Principal Investigators and Co-Investigators must have a strong track record of collaboration among the participating team members.
  • The proposal must not overlap with current NIH-funded program projects in which team members participate.
  • A specific plan for future funding mechanisms, including targeted agencies and RFAs, should be presented.

Letter of Intent (LOI):
NOTE: This is a competitive LOI process requiring submission of the following information (3 page maximum):

  • Descriptive title of proposed research
  • Summary of the proposed research project, the study team’s credentials, and an estimated total budget.
  • Name, degree(s), address, and telephone number of the Principal Investigator
  • Names and affiliations of other key personnel and participating institutions
  • Submit LOI online by October 9, 2015, 5pm PST.

Full Application:

  • Standard NIH-style research plan (including specific aims, significance, innovation, and approach). Applications (Research Plan) should be no longer than 6 pages single-spaced, Arial font 11 point, 0.5” margins.
  • Standard NIH-style Biosketches and Other Support pages (note: two separate forms).
  • Standard NIH-style budget and budget justifications. There is no indirect cost rate - the entire budget may be allocated for direct costs.

Additional Requirements:

  • Grantees must provide their NIH Commons ID and, if applicable, their regulatory approvals (e,g., IRB and/or IACUC and ESCRO numbers) listing CTSI funding support, before funds will be released.
  • Periodic project progress reports will be required; template/instructions will be provided.
  • Grantees are expected to present research findings at CTSI/CRI sponsored events as well as participate in CTSI and Cardiovascular Theme events (i.e., annual CTSI retreat, Cardiovascular Theme Annual Symposium and seminar series).
  • On all relevant presentations and publications, awardees must include an acknowledgment of support as follows:
    "Research was supported by the Clinical and Translational Science Institute (NIH) and the UCLA Cardiovascular Theme."

Any questions related to submitting an LOI and application for this RFA, please address to:
Dion Baybridge
(310) 794-7374
DBaybridge@mednet.ucla.edu

For all other questions related to this Cardiovascular Theme, please contact:
Brianne Bear, Administrator
(310) 206-2677
Bbear@mednet.ucla.edu

Team Science - Center for Duchenne Muscular Dystrophy

Center for Duchenne Muscular Dystrophy (CDMD)
and
UCLA Clinical Translational Science Institute (CTSI)

Team Science Award

The Center for Duchenne Muscular Dystrophy (CDMD) and the UCLA CTSI are soliciting applications for a team science award. The CDMD provides an academic home to researchers in the Los Angeles area interested in discovery and translation of therapies in the muscular dystrophies. (www.cdmd.ucla.edu). The goals of the CDMD are to identify disease modifying drug targets, perform intelligent drug design and conduct clinical trials. To be eligible to apply, two or more PIs must jointly propose a new project that is likely to lead to extramural funding, and serve the dual purpose of promoting collaboration and attracting investigators that broaden the research base. Both basic science and clinical research studies will be considered.

CDMD/CTSI Team Science Grant Program

The purpose of the program is:

  1. To provide seed grants to PIs proposing promising or high risk projects in the muscle field, for which preliminary data are lacking,
  2. To support researchers who are not experienced in muscle research, but who have a novel idea or hypothesis that merits investigation and
  3. To provide support to junior level investigators interested in muscle research.

Eligibility
All applicants must join the Center at the time of application. Faculty located at all UCLA CTSI partner institutions are eligible to apply for CDMD membership.

The Application and Judging Process
Proposals will be evaluated by the Executive committee using the NIH scoring system (1-9 scale). When evaluating the proposals, the executive committee will consider the merits of each proposal based on the strength of the hypothesis, the experimental approach and potential to lead to a successful NIH grant application. Applications that are more aligned with the mission of the CDMD to promote translational research in the muscular dystrophies will be viewed with greater enthusiasm.

Award Details

  1. Each proposal is intended to be for a maximum of one year, but exceptions can be made.
  2. The maximal dollar amount that will be awarded is $100,000 per project. Budgets should be divided relatively equally between the partnership, unless justified.
  3. To foster collaboration, Center Investigators can be collaborators on Team Science projects more than one time.
  4. Projects using at least one CDMD core will be given priority. Some of the money committed to the use of cores will be provided as ‘voucher’ for Core usage
  5. An investigator that accepts funding is agreeing to submit a 1-page project report at prior to the end of each year of funding, acknowledge the funding from P30 on all publications, acknowledge CTSI on all publications, and update both the UCLA CTSI and CDMD on subsequent funding received on an annual basis.

How To Apply
The application deadline is July 5th, 2014 for a start date of July 15th, 2014. Applications should be made into a single pdf and emailed to Amy Martin (amymartin@ucla.edu).

A complete application in NIH format should include the following:

  1. An experimental plan (6 page maximum) that includes the following sections 1) Abstract 2) Background, 3) Preliminary Data, 4) Experimental Plan and 5) paragraph explaining how the data arising from the funding will promote muscle research in the PIs laboratory.
  2. NIH biosketch for each investigator involved in the application.
  3. An annual budget ($100,000 maximum for 1 year).

CTSI Specific Requirements:

  1. The continued funding of the CTSI grants is dependent on the program’s success. For this reason, it is important that any publications (journal articles, websites, papers, testimonials, etc.) resulting in whole or in part from this project should acknowledge support from both by including the following statement: “This project received support from both the NIH/NCATS UCLA CTSI Grant Number UL1TR000124” and the BRI.
  2. Please notify the CTSI and BRI of any subsequent extramural grant support obtained that is relevant to this grant funding.
  3. Prior to transfer of these funds, appropriate IRB/ARC approvals must be in place. In accordance with NIH policy, please amend your relevant IRB and/or ARC protocol to disclose funding support from the UCLA CTSI Grant number UL1TR00124.
  4. Please submit copies of your IRB, and/or ARC approval to Deborah Herman (dkherman@mednet.ucla.edu).
  5. The applicants must specify the exact extramural funding mechanism being targeted and application deadline (e.g., NHLBI P01 for July 1, 2014).
  6. Applicants must identify specific CTSI resources to be utilized and explain how the proposed research is translational.
  7. Progress reports and end‐of‐project reports will be required; templates will be provided. Presentations of posters at BRI and CTSI‐sponsored meetings are encouraged.

Team Science - Children's Discovery and Innovation Institute (CDI) and CTSI Children’s Health

Letter of Intent Due Date: February 10, 2015 (Finalists for full applications notified by March 6, 2015)
Application Due Date: May 1, 2015, 5 pm PST
Funding Period July 1, 2015 - June 30, 2016
Funding Amount: Up to $100,000/year for one year to support salary, benefits and research supplies
Online Application: https://rfp.ctsi.ucla.edu/Awards/chtsa-loi/

The UCLA Clinical and Translational Science Institute (CTSI) and the UCLA Children's Discovery and Innovation Institute (CDI) are pleased to announce the CTSI/CDI Children's Health Team Science Award for research teams from UCLA and CTSI partner institutions (Cedars-Sinai, Charles R. Drew University, LA-Biomed) and CTSI-affiliated institutions (RAND, Olive View UCLA Medical Center, Santa Monica UCLA Medical Center, VA Greater Los Angeles Healthcare System) to conduct novel, multidisciplinary, team-oriented and high-impact research in Children's Health. The team-oriented approach is essential to the feasibility and potential success of the proposal. Applicants are encouraged to follow NIH-style grant guidelines and scientific review criteria for their research proposals. Teams are expected to generate data that will lead not only to academic products but also to the submission of high-quality R01- level or P01-level proposals to public agencies or private foundations.

The CTSI/CDI Children's Health Team Science Award will support four initial CDI research themes, intended to be broadly and inclusively interpreted, to help investigators develop forums for this multidisciplinary work. Each team should have a central focus on a related set of clinical disorders related to these research themes.

  • Brain, Behavior, and Development
  • Cancer and Regeneration
  • Infection, Inflammation, and Immunity
  • Nutrition, Metabolism, and Growth

Specific Requirements:

  • The research team must be led by a Principal Investigator (PI) who is full-time faculty at UCLA or CTSI partner or affiliate institution with a proven track record of high-impact research and productivity and leadership in the research theme.
  • Principal Investigators and Co-Investigators must have a strong track record of collaboration among the participating team members.
  • Proposal must not overlap with current NIH-funded program projects in which team members participate.

Letter of Intent (LOI):
NOTE: This is a competitive LOI process requiring submission of the following information (3 page max):

  • Descriptive title of proposed research and the primary CDI research theme addressed
  • Summary of the proposed research project and the study team’s credentials, and an estimated total budget.
  • Name, degree(s), address, and telephone number of the Principal Investigator
  • Names and affiliations of other key personnel and participating institutions
  • Submit LOI online at: https://rfp.ctsi.ucla.edu/Awards/chtsa-loi/ by February 10, 2015

Full Application:

  • Standard NIH-style research plan (including specific aims, significance, innovation, and approach). Applications (Research Plan) should be no longer than 12 pages single-spaced, Arial font 11, 0.5” margins.
  • Standard NIH-style Biosketches and Other Support pages (note: two separate forms).
  • Standard NIH-style budget and budget justifications. There is no indirect cost rate - the entire budget may be allocated for direct costs.

Additional Requirements:

  • Grantees must provide their NIH Commons ID and, if applicable, their regulatory approvals (eg. IRB and/or IACUC and ESCRO numbers) listing both CTSI and CDI funding support, before funds will be released.
  • Periodic project progress reports will be required; template/instructions will be provided.
  • Grantees are expected to present research findings at CTSI/CDI sponsored events as well as participate in CTSI and CDI events (i.e., annual CTSI retreat, annual CDI research symposium and seminar series).
  • On all relevant presentations and publications, awardees must include an acknowledgment of support to read "Research was supported by the Clinical and Translational Science Institute (NIH) and the UCLA Children's Discovery and Innovation Institute” (logos will be provided).

Any questions related to submitting an LOI and application for this RFA, please address to:
Dion Baybridge
(310) 794-7374
DBaybridge@mednet.ucla.edu

For all other questions related to this CDI research program, please contact:
Candace J. Wilkinson, Ph.D.
Scientific Officer, UCLA Children’s Discovery and Innovation Institute (CDI)
(310) 794-4336
CWilkinson@mednet.ucla.edu

Team Science - Immunity, Inflammation, Infection and Transplantation (I3T)

IMMUNITY, INFLAMMATION, INFECTION, AND TRANSPLANTATION (I3T) THEME
REQUEST FOR APPLICATIONS FOR TEAM SCIENCE AWARDS

Posted: February 10, 2014
Letter of Intent Due Date: March 3, 2014
Letter of Intent Decisions: March 10, 2014
Application Due Date: April 28, 2014
Earliest Funding Date: June 1, 2014

Grant Type: Team Science Award
Award Period: One Year
Number of Awards: One or Two Each Year
Direct Costs: $200,000 Maximum

Hundreds of laboratories within the David Geffen School of Medicine, within CTSI partner institutions, and throughout the UCLA campus have research interests and expertise that are relevant to the recently established Theme in Immunity, Inflammation, Infection, and Transplantation (I3T) within the School of Medicine. Additionally, UCLA physicians and physician-scientists have expert knowledge of relevant clinical needs and access to patients and patient samples. Given this breadth of activity, it should be possible to assemble teams of basic researchers, physicians, and physician scientists, sometimes including engineers, public health researchers, and social scientists, to pursue major scientific challenges and unmet clinical needs. Although individual investigator-initiated research projects will continue to yield important advances, there is a growing realization that team efforts have lagged behind, despite the potential impact of projects that bring together researchers and clinicians with complementary expertise. Furthermore, more and more funding from the NIH and from other government agencies and private foundations is being devoted to team efforts, and team efforts are of greater interest to philanthropists and potential corporate partners.

With the above issues in mind, the UCLA I3T Theme, in partnership with the CTSI, announces its first round of Team Science Awards. Each applicant team must consist of at least three faculty from UCLA and/or a CTSI partner institution. Co-Investigators from other institutions are permitted, but only when added to a team that includes at least three faculty from UCLA or a CTSI partner. Research projects that address a specific clinical need and that involve both basic researchers and clinicians are of greatest interest, but any new collaborative effort will be given full consideration.

The five most important review criteria will be:

  • Scientific excellence and potential scientific or clinical impact
  • Record of accomplishments of the team members
  • Potential of the project to lead to a multi-investigator grant, a corporate partnership, or intellectual property
  • Extent to which the project addresses a clinical need
  • Extent to which the team includes researchers with diverse expertise, including clinical participants


The application timeline is listed above. Letters of intent (LOIs) should include a 1-2-page description of the project, the names and affiliations of key faculty participants in the project (please indicate the project leader), and NIH-style biosketches for each key participant. These documents should be assembled into a single PDF, which can be forwarded to Dion Baybridge at dbaybridge@mednet.ucla.edu.

Those who are invited to submit a full application should prepare an application according to the instructions for an NIH R21 application. Specifically, the application should include a one-page Specific Aims document, a six-page Research Strategies document that includes Significance, Innovation, and Approach sections, and a Literature Cited section. Preliminary results are not necessary, but should be included if available. These scientific sections should be accompanied by an NIH-style itemized budget and biosketches for each key participant. Copies of IRB and ARC approvals or status of applications should also be included.

Team Science - Neuroscience

Submission: Online CTSI website at http://www.ctsi.ucla.edu/Awards/TSATansNeuro/tsa-neuro-view

Date & Time: Proposal should be submitted by 5:00 pm PST on April 1, 2013.

Grant Description: The Neuroscience/CTSI community is accepting applications for Team Science Award in Translational Neuroscience from research teams at CTSI partner and affiliate institutions to conduct multidisciplinary, team-oriented and high-impact research in the area of neuroscience. Each research team will receive up to $100,000 from CTSI to be matched by an equal amount in matching funds shared by the UCLA Brain Research Institute, the Departments of Neurobiology, Neurology, Neurosurgery and Psychology, and the Semel Institute for Neuroscience and Human Behavior. The award provides maximum support of up to $200K for one year for salary support, benefits and research supplies. We intend to fund 1-2 proposals.

Specific Information:
Team Science Award in Translational Neurosciences
The Neuroscience Community in collaboration with the UCLA Clinical and Translational Science Institute is pleased to announce the UCLA Neuroscience/CTSI Team Science Award in Translational Neurosciences for research teams from CTSI partner institutions (UCLA, Cedars-Sinai, Charles R. Drew University, LA-Biomed) and CTSI-affiliated institutions (RAND, Olive View UCLA Medical Center, Santa Monica UCLA Medical Center, VA Greater Los Angeles Healthcare System) to conduct novel, multidisciplinary, team-oriented and high-impact research in the area of neuroscience. The Team Science Award in Translational Neurosciences is intended to catalyze team science among CTSI partner and affiliate institutions to plan for submission of large extramural grants. Neuroscience related disorders and diseases represent a major challenge in health care with limited therapeutic options. This initiative is specifically designed to meet an important goal of the UCLA CTSI: To support emerging, high-impact, multidisciplinary research programs that aim to tackle the multi-factorial complexity in the mechanisms and manifestations of the diseases, and to promote accelerated translation between basic science research and clinical practice.

Who May Apply:
The Neuroscience/CTSI Team Science Award seeks to fund new research teams of established investigators utilizing innovative, shared research approaches, tools, models and concepts to bring a new paradigm to our current understanding and to have a transformative impact in the field.

Specific Requirements:

  • The research team must have multiple projects that revolve around a specific area of translational neuroscience and use complimentary and synergistic approaches. The team-oriented approach is essential to the feasibility and potential success of the proposal.
  • Research teams must be led by a principal investigator (PI) who is full-time faculty at a CTSI partner or affiliate institution with a proven track record of high-impact research and productivity and leadership in the research area.
  • Each research project must be led by a project leader who is a full-time faculty at one of the CTSI partner or affiliate institutions and has recognized expertise to lead the proposed project.
  • The proposal should not overlap with any current NIH-funded program projects or center grants in which team members participate.

Selection Criteria:

  • Significance: The proposal should have substantial impact to advance our current understanding of a brain disorder or disease and to translate the new knowledge into more effective and personalized therapies.
  • Innovation: The novelty of the proposal will be evaluated at conceptual, methodological and organizational   levels. Newly established collaborative efforts will be a priority for this funding source.
  • Teamwork: The proposal should foster stronger interaction among existing collaborations and create new opportunities for additional collaborations to enhance synergy. Projects that cross CTSI partner affiliate institutions are preferred but not required.
  • Feasibility: Strong preliminary results and track record of the expertise among team members.
  • Productivity: Record of high-impact publications among team members.

Submission Guidelines: (must use standard NIH page setup and font requirements)

  • An abstract of maximal 600 character limit research description in Lay language
  • One page of Specific Aims limited to 3,000 characters
  • No more than FIVE pages of Research Proposal including Significance, Innovation, Preliminary Data and Experimental Plan.
  • Program Development. One-page describing team organization, synergy and program development.
  • Plans for supporting the project beyond the grant period limited to 3,000 characters.
  • NIH-formatted biosketches (4-page limit with maximal of 15 representative publications) for the principal investigator, project leaders and key personnel.
  • A consolidated resource page stating major infrastructure and institutional support specifically for the proposal.
  • Review will be conducted by a committee charged by the Neuroscience Planning Committee. This includes initial distribution to experts for peer review and evaluation with scoring on a scale from 1 to 10. Please note that written critiques cannot be provided as CTSI guarantees all Faculty members that their comments and scores are confidential

Additional Requirements:
The applicants must specify the exact extramural funding mechanism being targeted and application deadline (e.g., NHLBI P01 for June 1, 2013). Applicants must identify specific CTSI resources to be utilized and explain how the proposed research is translational. Progress reports and end-of-project reports will be required; templates will be provided. Presentations of posters at BRI and CTSI-sponsored meetings are encouraged. Successful applicant Co-PIs must provide their field of specialization and their NIH Commons ID.

CTSI Specific Requirements:
Prior to transfer of these funds, appropriate IRB/ARC approvals must be in place. In accordance with NIH policy, please amend your relevant IRB and/or ARC protocol to disclose funding support from the UCLA CTSI Grant number UL1TR00124; please submit copies of your IRB, and/or ARC approval to Dion Baybridge, (catalyst@ctsi.ucla.edu).
The continued funding of the CTSI grants is dependent on the program’s success. For this reason, it is important that any publications (journal articles, websites, papers, testimonials, etc.) resulting in whole or in part from this project should acknowledge support from both by including the following statement: “This project received support from both the NIH/NCATS UCLA CTSI Grant Number UL1TR000124”. Please notify the CTSI of any subsequent extramural grant support obtained that is relevant to this grant funding.

Budgets:
Proposals must include budget and budget justification using NIH format, including personnel costs, specific planning activity costs and other support for key personnel. No indirect costs are allowed.

Award Date:
Funding will start on July 1, 2013 upon approval from CTSI and after all required documents are received by the Brain Research Institute. The award period will be for one year.

How to Apply:
Online CTSI website at http://www.ctsi.ucla.edu/Awards/TSATansNeuro/tsa-neuro-view
Please address questions related to this RFA, to Ms. Terry Novorr at tnovorr@mednet.ucla.edu

UCLA Brain Research Institute (BRI)
695 Charles E. Young Drive South #1506
Los Angeles, CA 90095
(310) 825-5062 (Phone)
(310) 206-5855 (Fax)

Translational Neurodegeneration/Neural Repair Research

Brain Research Institute, Integrative Center for Neural Repair & the Clinical and Translational Science Institute Research Awards

General Information:
RFA for Proposals in Translational Neurodegeneration and Neural Repair The UCLA BRI and Integrated Center for Neural Repair (ICNR) in collaboration with the CTSI is pleased to announce an RFA for Awards for Translational Neurodegeneration/Neural Repair Research.

The awards are intended to catalyze extramural funding for innovative, collaborative and translational neuroscience within and among CTSI partner and affiliate institutions.

Proposal Submission Date & Time:
Proposal must be submitted by the close of business on February 28th, 2014 by 5:00 pm PST.

Project Period Dates:
The award period will be for one year. Funding will start on July 1, 2014 upon approval from BRI and CTSI, and after all required documents are received. Prior to transfer of funds, appropriate IRB/ARC approvals must be in place.

How to Apply:
Online via CTSI website - click here to go to online application.

Grant Description:
UCLA Brain Research Institute (BRI) donors have given $100,000 specifically in support of Alzheimer's and Parkinson's research. The UCLA Clinical and Translational Science Institute (CTSI) has agreed to co‐sponsor with the BRI an RFA with matching funds of an additional $100,000 allowing increased scope of proposals to include translational research in all aspects of Neurodegeneration or Neural Repair. Evaluation of proposals will be conducted by the Integrative Center for Neural Repair (ICNR) and the Committee overseeing the new DGSoM Regeneration/Degeneration and Repair theme. This RFA will fund up to 4 projects (maximum $50,000 per project) that demonstrate collaborative and innovative research, and that will increase competiveness for NIH awards for translational research or clinical trials. Two of the four projects will be funded within the Alzheimer’s and/or Parkinson’s fields. The remaining two projects can be within basic science or clinical study of neurodegeneration or neural repair. Priority will be given to projects from productive faculty facing financial obstacles as a result of the current funding climate.

Who May Apply:
Applications must be from a faculty member in a CTSI partner institution or a CTSI‐affiliated institution: UCLA, Cedars‐Sinai, Charles R. Drew University, LA‐Biomed, Olive View UCLA Medical Center, RAND, Santa Monica UCLA Medical Center, VA Greater Los Angeles Healthcare System.

If there are questions concerning responsivity to the RFA of a potential application please contact Marie-Francoise Chesselet at mchesselet@mednet.ucla.edu.

Specific Requirements:

  • The research must be led by a principal investigator (PI) who is full‐time faculty at a CTSI partner or affiliate institution (UCLA applications must be from a PI who is a member of the Academic Senate), with a proven track record of high‐impact research.
  • Applications are welcome both from investigators refocusing their research to studies of neurodegeneration or neural repair as well as those established in this area of neuroscience.
  • The research project should aim to be translational, collaborative, multidisciplinary and innovative.
  • The proposal should not overlap with any current NIH‐funded projects.
  • Funding should not be used for PI salary support.

Selection Criteria:
Impact: The proposal should have substantial impact to advance our current understanding and potential treatments of a neurodegenerative disease or neural repair process.
Novelty: The novelty of the proposal will be evaluated.
Collaborative and Multidisciplinary: Projects that are multidisciplinary and collaborative will be a high priority.
Feasibility and Productivity: Preliminary results and track record will be considered in relation to current funding.

Submission Guidelines:
Please refer to example NIH forms and their guidelines, use standard NIH form page/formats, and use NIH font/format requirements when completing the following documents. All character counts referenced below include spaces.

  1. An abstract research description in lay language, limited to 600 characters.
  2. One page Specific Aims, limited to 2,000 characters.
  3. No more than a 3 page Research Proposal including Significance, Innovation, Preliminary Data and Experimental Plan.
  4. NIH‐formatted Biosketch with all other financial support listed (4‐page limit with maximal of 15 representative publications) for PI and all key personnel.
  5. Plans for supporting the project beyond the grant period, limited to 2,000 characters.
  6. NIH form page 4 budget page/s, and a detailed budget justification for supply/other direct costs, and support of all personnel. No indirect costs are allowed.

CTSI Specific Requirements:

  1. The continued funding of the CTSI grants is dependent on the program's success. For this reason, it is important that any publications (journal articles, websites, papers, testimonials, etc.) resulting in whole or in part from this project should acknowledge support from both by including the following statement: "This project received support from both the NIH/NCATS UCLA CTSI Grant Number UL1TR000124" and the BRI.
  2. Please notify the CTSI and BRI of any subsequent extramural grant support obtained that is relevant to this grant funding.
  3. Prior to transfer of these funds, appropriate IRB/ARC approvals must be in place. In accordance with NIH policy, please amend your relevant IRB and/or ARC protocol to disclose funding support from the UCLA CTSI Grant number UL1TR00124.
  4. Please submit copies of your IRB, and/or ARC approval to Deborah Herman (dkherman@mednet.ucla.edu).
  5. The applicants must specify the exact extramural funding mechanism being targeted and application deadline (e.g., NHLBI P01 for June 1, 2014).
  6. Applicants must identify specific CTSI resources to be utilized and explain how the proposed research is translational.
  7. Progress reports and end‐of‐project reports will be required; templates will be provided. Presentations of posters at BRI and CTSI‐sponsored meetings are encouraged.

Questions:
Please send questions related to this RFA, to Ms. Terry Novorr (tnovorr@mednet.ucla.edu).
UCLA Brain Research Institute (BRI)
695 Charles E. Young Drive South #1506
Los Angeles, CA 90095
(310) 825-5062 (Phone) (310) 206-5855 (Fax)

UCLA California Behavioral Health Center of Exellence / CTSI Rapid Research Advances for Progress In Disparities (RRAPID) Mental Health Awards

UCLA California Behavioral Health Center of Excellence at UCLA and
UCLA Clinical Translational Science Institute (CTSI)
Rapid Research Advances for Progress in Disparities (RRAPID)
Mental Health Awards

OVERVIEW:  The California Behavioral Health Center of Excellence at UCLA is collaborating with the UCLA CTSI to stimulate rapid progress in addressing mental health disparities through quick turnaround, high-yield research projects and innovative approaches that foster community and stakeholder partnerships to advance fundamental science, services and outcomes with a focus on those suffering mental illness and populations facing disparities in mental health services access, quality or outcomes.  The goals are to produce a research product and build partnerships through two-way knowledge exchange between researchers and stakeholders (systems, providers, clients/families).  The research should have relevance or potential relevance for the California Mental Health Services Act (MHSA; prevention, early intervention, services innovation and full-service partnerships for mental disorders; addressing mental health disparities; suicide prevention and criminal recidivism) or for the CTSI more broadly for behavioral disorders (ie., including neurodevelopmental disorder and degenerative disease).  The awards may support research and partnership development across a broad range of science, from basic and translational to clinical, behavioral, services, community engagement and policy. The mechanism supports publications and partnership development for early stage investigators as defined by NIH (see NIH definition here: http://grants.nih.gov/grants/new_investigators/index.htm#earlystage). For example, papers from dissertations or other existing data, or pilot data on partnership development and documentation of strategies to address challenges of research engagement, to increase feasibility, external validity and success of a proposal with stakeholder input, collaboration, and community translation.

The disparity populations featured to date by the MHSA include: African American, Latino, Asian and Pacific Islander, Native American, LGBTQ and rural communities. Inclusion of MSHA-relevant stakeholders in basic and translational science projects can increase the capacity to understand and utilize such advances in underserved populations. Because disparity populations are often under-represented in research, the provision of developmental support will be considered for projects focusing on populations with little prior MHSA-relevant research.

Projects should:

  1. have relevance or potential relevance to issues of importance to the MHSA;
  2. promote stakeholder input/capacity building and researcher knowledge of stakeholder-relevant issues;
  3. result in a research paper, research proposal or stakeholder workshop or other activity within 1 year;
  4. lead to a presentation or poster for the Center Research & Stakeholder Advisory Board and CTSI;
  5. feature a lead role for an early stage investigator;
  6. identify a senior faculty mentor from a UCLA CTSI institution (no compensation); a consultant or co-mentor from a Semel Institute research center is preferred to facilitate fund management and coordination. A consultant or mentor from another CTSI institution (e.g., UC Davis, USC) is encouraged but not required.


Eligible applicants must submit a “letter of intent” summarizing the proposed work and identifying a mentor. This concept piece should be limited to 400 words and e-mailed as a pdf to liz7@ucla.edu. Selected applicants will be notified by 1/31/16 and invited to submit a full application.

Key Dates

Letter of Intent deadline: January 15, 2016 by 5PM

Full Application deadline: March 15, 2016 by 5PM

Earliest start date: April 1, 2016

Budget period: April 1, 2016 - March 31, 2017

Award Budget: Direct costs are limited to $25,000 (this mechanism does not fund Indirect Costs)

Funds can be used for an early stage investigator investigator and support staff salary, consultation from partners/methodologists, participant payments, community events, supplies or travel. At least 10% of the budget should facilitate stakeholder involvement, such as consultant, community workshop.

Eligible Applicants 

Junior faculty, psychiatry residents in training, pre or post-doc fellows at UCLA Semel Institute or CTSI-affiliated institution (Cedars, Harbor, Charles R Drew) but preferably collaborating with a Semel Institute research center to facilitate fund management and coordination.

The Center is developing relationships with diverse stakeholders across Los Angeles County relevant to MHSA goals, with a focus on public sector agencies serving under-resourced populations. These stakeholders can be available as community mentors for RRAPID Awards upon request.

The Center with CTSI support will support up to 10 awards (4/1/16 - 3/31/17).


APPLICATION INSTRUCTIONS
Beginning February 1, 2016, invited applicants will be able to submit an application via the following link: http://hss.semel.ucla.edu/rrapid. Complete the information requested online and attach the items described below in the order listed as a single pdf document. Formatting requirements for the attachments includes use of Arial font size 11 or larger and .5 inch margins all around.

Research Plan

The research plan consists of the below sections:

Specific Aims
limited to 1 page
The specific aims should summarize the expected outcomes of the research proposal.

Research Strategy
limited to 5 pages
The research strategy should articulate how the proposed work is relevant or potentially relevant to the MHSA and specify the approach being proposed.  The Investigator team including stakeholders should be identified and a brief description of their role should be included.  In addition, the specific end product should be described along with a timeline for carrying out the work.

References limited to 1 page
Provide a bibliography of any references cited in the research plan following the AMA citation style.

Other Required Sections
NIH biosketchlimited to 4 pages
An NIH biosketch is required for the early stage investigator and senior mentor.
A resume is required for the stakeholder partner.  If no stakeholder is identified at the time of proposal submission, please check “Request for Stakeholder Assignment” box.

Budget and Budget Justification no page limit
A PHS 398-style detailed budget is required along with a budget justification describing how the funds requested directly support the proposed work.

Letter of Recommendation
limited to 2 pages
A letter of recommendation from the senior mentor describing the junior investigator’s qualifications is required.  The letter should include a statement regarding the mentor’s commitment to protecting time for the early stage investigator to conduct the proposed work and describe resources available to him or her.

IRB Approval Letter

Attach a copy of the IRB approval for the proposed work.

Please direct any questions regarding this funding opportunity to Elizabeth Lizaola, liz7@ucla.edu.

UCLA Center for Autism Research and Treatment (CART) - Pilot Grant

Pilot Funding Available for UCLA Researchers

APPLICATION DEADLINE: April 21, 2017 (Friday, by 5 pm)
FUNDING AMOUNT: $25,000 per project (direct costs only)
BUDGET PERIOD: July 1, 2017 - June 30, 2018


The UCLA Center for Autism Research and Treatment (CART) invites applications for grants to fund pilot and/or feasibility studies for biomedical, epidemiological, or behavioral research. This funding is made available with departmental “Autism Initiative” funds to CART and matching funds via the UCLA CTSI Voucher Fund. The UCLA CART houses several ACE Networks funded by NIH as part of a nationwide set of research programs. UCLA CART activities are wide-ranging and include the integration of clinical, imaging, genetic, and basic science research to create a synergistic milieu that maximizes the productivity of the participants and attracts other investigators to the field of autism.

PURPOSE: The purpose of these awards is to foster interactions and interdisciplinary research projects in the basic and clinical areas of autism. Preference will be given to projects that are likely to lead to successful future funding (by R01-type awards, etc). Proposals addressing the mechanism and treatment of autism are encouraged. Projects can also build upon the UCLA CART’s mission and current research activities. Descriptions of CART’s mission and research, including the previously funded pilot grants, are available at our website at: www.autism.ucla.edu.

ELIGIBILITY: Funds are available to the UCLA academic community, faculty associated with UCLA CTSI institutional partners (Cedars-Sinai Medical Center, Charles Drew University of Medicine and Science and Los Angeles Biomedical Institute at Harbor-UCLA Medical Center), and UCLA affiliates (VA Greater Los Angeles Healthcare System, Olive View-UCLA Medical Center, Santa Monica-UCLA Medical Center, and RAND), in any series (including adjunct and professional research) including new investigators, investigators from other fields willing to bring their research expertise to autism studies, and for investigators whoseproposed research would constitute feasibility testing. Funds are not intended to supplement ongoing supported research of an established investigator. Only full-time faculty are eligible. Postdoctoral fellows are not eligible.

AWARD TERMS: These pilot project awards are for one-year only and are limited up to $25,000 (direct costs only) per project. Funds will not be awarded for equipment costs, for salary or benefits for the principal investigator, or for postdoctoral fellows or any study personnel who hold an academic appointment. An investigator is eligible only once for the pilot support unless the additional proposed study constitutes a substantial departure from the previous research. All applications involving humans or animals must have IRB or ARC approval at UCLA or an UCLA-affiliated institute before the funds will be released. The funding period for the FY 2017-18 award is July 1, 2017 - June 30, 2018.

APPLICATION GUIDELINES: The proposals must present a testable hypothesis, clearly delineate the question(s) being asked, detail the procedures to be followed, and discuss how the data will be analyzed. Specifically, the proposals may be up to 5 pages and must include: Abstract (250 words or less), Specific Aims, Background, Preliminary Studies, Experimental Design and Methods, and Significance. In addition, the literature references should be attached along with the following NIH (PHS 398) standard forms: the investigator’s 5-page biographical sketch, budget with detailed justification, and other outside funding support. If funded, the investigator will also need to provide a summary of the project in lay language and be willing to present the findings at a CART lecture series and meetings.

Please email the complete application as one PDF on or before Friday, April 21, 2017, by 5pm to the CART Director of Operations: Monica Belli, mbelli@mednet.ucla.edu.

If you have questions, contact Monica Belli at 310-825-9041 or e-mail: mbelli@mednet.ucla.edu.

UCLA Center for Ulcer Research and Education (CURE): Digestive Diseases Research Center Pilot and Feasibility Study (PFS)

CTSI/CURE Pilot and Feasibility Study (PFS)

The Center for Ulcer Research and Education: Digestive Diseases Research Center (CURE: DDRC) and the UCLA Clinical and Translational Science Institute (CTSI) invite applications (new or second year renewal) for the 2017 academic year. Funding will be available for high quality and innovative research in the biology, function and diseases of the digestive system, which is of relevance to the overall CURE Research Program, with special emphasis on receptor and signal transduction mechanisms, brain-gut interactions, gastrointestinal and pancreatic physiology and inflammation, and mechanisms underlying diseases of the digestive system. Proposed projects should lead to peer-reviewed extramural funding such as NIH, VA or related agency research grants in which PFS awardees serve as Principal Investigators. Awards range from $20,000 to $35,000/year.

Eligibility

Category 1. New investigators without current or past NIH or related agency research support as principal investigators, who are seeking to establish their own independent research program. Young investigators supported by Career Development or Mentor awards (e.g. K01, K08 or similar) are considered eligible for category 1 and encouraged to apply for PFS funding.
Category 2. Established investigators with currently active research support, who have not been involved in research of the digestive system and who want to enter this field of research.
Category 3. Established investigators with currently active support for research in the digestive system, who want to pursue a new research direction in the field of gastroenterology, which represents a significant departure from their funded research.  

Highly innovative proposals are encouraged. Category 1 is given preference.

Award Terms

  1. Applicants must hold a Ph.D., M.D. or equivalent degree and have at least 2 years of postgraduate research experience.
  2. Trainees who are recipient of an NRSA individual award (F32) or are supported by an institutional training grant (T32), or fellowship are eligible in their last year of training.
  3. Applicants must have a UCLA appointment in an academic track (research fellows or postdoctoral scholars are included) by the time of the award.
  4. New investigators without independent support need to provide documentation of support (i.e. space available and financial support beyond the PFS fund) of a UCLA or VA faculty sponsor.
  5. An investigator is eligible only once for PFS support with the exception of new investigators (category 1) whose previous PFS has resulted in independent funding and are now eligible to apply as category 3.
  6. Applicants are required to use at least one Center core in addition to the Administrative Core (see website for list of Cores and services at http://www.cure.med.ucla.edu) and must perform research at CURE (VA or UCLA) and/or UCLA only. 
  7. Applications establishing collaborative interactions within the Center are encouraged.
  8. CTSI Reporting Requirements will be distributed at the time of the award notification.

Application Process

Letter of Intent
The deadline for the submission of the one-page letter of intent and the applicant’s NIH-style biosketch has been extended to September 19, 2016. Please, submit it as e-mail attachment to the program coordinator, Jacqueline Ismen (JIsmen@mednet.ucla.edu). The letter of intent should include 1) the applicant name, rank and affiliation, 2) the category (see eligibility for the categories) for which the applicant wishes to apply, 3) the proposal title, 4) the hypothesis and a paragraph describing the salient features of the project, 5) which core(s) of the CURE: DDRC will be used, 6) the mentor’s funded research project(s), if the applicant is a junior investigator without independent funding, or of other funded project(s), if the applicant is a senior investigator, and 7) how the proposed project will differ from the funded projects. If the applicant is a PFS awardee who wishes to apply for a second year funding, a progress report of past supported research must be added to the letter of intent for evaluation. Applicants will be notified of their eligibility to submit a full application. The letter of intent (no more than one page in length), the NIH biosketch and the progress report (if applicable) should be submitted as a single pdf document. Documents not conforming will be returned. Applicants will be notified of their eligibility to submit a full application. The template for the letter of intent and instructions for full applications can be found on the CURE:DDRCC website http://www.cure.med.ucla.edu).

Full Application Deadline

Full Application Deadline: November 7, 2016
Starting Date: March 1, 2017 

UCLA/CDU RCMAR/CHIME & CTSI Pilot-Study Awards

UCLA/CDU Resource Centers for Minority Aging Research
Center for Health Improvement of Minority Elderly (RCMAR/CHIME) and
UCLA Clinical and Translational Science Institute (CTSI)

http://www.chime.med.ucla.edu/apply

Applications being accepted for three (3) one-year NIH/NIA-funded Pilot-Project Awards up to $40,000 each for project period between 07/01/2016 to 06/30/2017

Who Should Apply: Applications are being accepted from minority junior- and mid-level faculty and post-doctoral researchers who have or will have an appointment between 07/01/2016 – 6/30/2017 at UCLA or another academic institution in the greater Los Angeles area and who are interested in conducting a pilot research project on minority elderly populations.

Funding Amount Available: Three (3) one-year pilot-project awards are available of up to a total of $40,000 each: up to $20,000 from the UCLA / Charles R. Drew University (CDU) Resource Center for Minority Aging Research / Center for Health Improvement of Minority Elderly (RCMAR/CHIME) (NIH/NIA Grant #P30-AG021684) and up to $20,000 from the UCLA Clinical and Translational Science Institute (CTSI) (NIH/NCATS Grant #UL1TR000124).

Focus of Pilot-Study Projects: Support will be given to pilot research projects that are consistent with the goal of the UCLA/CDU RCMAR/CHIME, which is to provide a research infrastructure of training and mentoring to minority junior- and mid-level faculty and post-doctoral fellows so that they can advance their academic careers by conducting projects that contribute to the reduction of health disparities affecting minority elders. Typically, pilot projects that are selected involve primary data collection and/or secondary data analysis that aim to address disparities in the health care of minority elders. Ideally, these pilot projects demonstrate effective inter-institutional and/or academic-community partnerships. We do not fund pilot projects focused on basic science or clinical research (a branch of medical science that determines the safety and effectiveness of medications, devices, diagnostic products and treatment regimens intended for human use).

Application Submission Timeline and Selection Process: By 12pm, Friday January 8th, 2016, applicants must complete and submit the following required documents:

  1. Complete the required on-line application form on the RCMAR/CHIME website:
    http://www.chime.med.ucla.edu/apply
  2. Email the following required documents as Microsoft Word attachments to Arturo Gongora, RCMAR/CHIME Project Coordinator,agongora@mednet.ucla.edu
    1. A two-page synopsis describing the proposed pilot project single-spaced using Arial font 11-point typeface, with one-inch margins, on 8.5”x11”-size page, that must include:
      1. Title of project;
      2. Description of proposed pilot project including brief description of project design, and data to be collected or used in the pilot project;
      3. A specific statement about how the proposed pilot project is related to the RCMAR goal of supporting minority junior- and mid-level faculty and post-doctoral fellows who can advance their academic and research careers by conducting a pilot research project that contributes to the reduction of health disparities affecting minority elders;
      4. A brief timeline that documents the feasibility of completing the pilot project in one year;
      5. A specific statement about how this pilot project will inform the applicant’s future research and how it will lead to larger NIH or other agency funding;
      6. A description of the proposed pilot-study project investigator(s) and their roles on the project; and
      7. Proposed mentor(s) and a statement about their involvement and the role they will play in conducting this pilot project.
    2. Applicant's current Curriculum Vitae (CV).
    3. Proposed investigators and mentor’s(s’) newly formatted,current NIH Biosketch.
    4. Institutional Letter of Support: You must submit an institutional letter of support from either your department chair or division chief confirming that you will have a junior- or mid-level faculty or post-doctoral appointment between 07/01/2016 to 06/30/2017 and adequate "protected time" to conduct your proposed project.

Criteria for Selection of Synopses of Pilot Study: Applicants will be selected to submit a full proposal based on:

  1. Completing the required on-line application form and emailing the required documents listed above in Section 2A, 2B, 2C and 2D.
  2. Meeting junior- or mid-level faculty or post-doctoral fellow appointment and minority status requirements;
  3. Having academic and research credentials to conduct the proposed research;
  4. Demonstrating sufficient protected time to conduct the pilot project between 07/01/2016 and 06/30/2017.
  5. Qualifications of mentor(s) to assist with conducting proposed pilot project and career development;
  6. Quality of proposed pilot project and feasibility of it being completed within one year;
  7. Relatedness of proposed pilot project to the RCMAR/CHIME goal of supporting research that contributes to the reduction of health disparities affecting minority elderly populations; and
  8. Likelihood that proposed pilot project will lead to publication of at least one (1) first-authored, peer- reviewed manuscript plus subsequent funding from the National Institutes of Health, particularly the National Institute on Aging.

Timeline for Processing of Synopses:

  1. By 12pm Friday, January 8th, 2016, applicants must submit an on-line application on the RCMAR/CHIME website – http://www.chime.med.ucla.edu/apply – and must email the above-listed required documents to Arturo Gongora, at agongora@mednet.ucla.edu
  2. By approximately Friday, January 29th, 2016, candidates will be notified if they have been selected to prepare and submit proposals and some supporting documents.
  3. By approximately Monday, February 29th, 2016, selected candidates must submit proposals with supporting documents including a six-page, single-spaced research plan and detailed budgets and other supporting documents to Arturo Gongora at agongora@mednet.ucla.edu. Those candidates whose proposals are selected will be notified as soon as possible to submit full proposals and supporting documents that will be forwarded to the National Institutes of Health/National Institute on Aging (NIH/NIA), which funds the UCLA/CDU RCMAR/CHIME, for final approval before the funded- award can be dispersed after July 1st, 2016.

For more information about the UCLA/CDU RCMAR/CHIME (NIA Grant #P30-AG021684) & the UCLA CTSI (NCATS Grant #UL1-TR000124 go to:

UCLA CTSI-Los Angeles County Department of Health Services Collaboration Grants

UCLA Clinical and Translational Science Institute-Los Angeles County Department of Health Services (LAC DHS) Collaboration Grants provide up to $30,000 for a period of one year to test solutions that enable LAC DHS to improve and increase delivery of high quality, patient-centered services without increasing costs.  UCLA CTSI and LAC DHS anticipate making up to five (5) awards.

For information about deadlines, eligibility and requirements and the review process, please see the RFA.

This round of applications are due February 15, 2013 at 5:00 pm, 2013, Pacific Time.  Click here for details and to apply.

Primary Contact
Dion Baybridge

(310) 794-7374


How to co-fund a Team Science Award

Team Science Awards support, multidisciplinary teams and enable them to obtain preliminary data for extramural grants. They are co-funded by CTSI and other entities (e.g., departments or centers) and issued in amounts ranging from $25,000 to $200,000 for one or two years. They are non-renewable and awarded through competitive, peer-review using an open RFA.

Partnering with CTSI

To initiate the process, a department, center, ORU, etc. must send a letter of intent (LOI) to Dion Baybridge, Director of Research, David Geffen School of Medicine, dbaybridge@mednet.ucla.edu. The programmatic department, institute, center, ORU, etc. must raise and provide matching funds that would be available to all CTSI partner institutes. Faculty are not eligible to apply individually for this LOI as it is intended only for departments, institutes, centers, ORUs, etc. to develop the RFA.

The LOI must include:

  1. the scientific focus of the proposed RFA
  2. an administrative leadership plan
  3. total award and total non-CTSI co-funding (minimum non-CTSI share is 50% of award)

Previous Team Science Awards

CTSI has partnered with departments, centers to develop Team Science RFAs and issue competitive, peer- reviewed, co-funded awards. Examples include:

  • CTSI-UCLA Department of Medicine, Department of Anesthesiology
    • Yibin Wang, “Systems Genetics of Heart Failure: Paving the Road to Translation.”
  • CTSI-UCLA Department of Medicine, Division of Infectious Disease
    • Debika Bhattacharya, “Cardiovascular and Metabolic Complications of HIV and HCV Co-Infection”
  • CTSI-UCLA Department of Human Genetics
    • Steve Horvath, “Diagnostic and Prognostic Biomarkers for HIV-Associated Non-AIDS (HANA) Condition”