Jing Wen

Title(s)Assistant Adjunct Professor, MIMG
SchoolMedicine
ORCID ORCID Icon0000-0002-6127-6276 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Dalian University of Technology, Dalian, ChinaB.S.2006Chemical Engineering
    Tianjin University, Tianjin, ChinaPh.D2011Biomedical Engineering
    University of California Los Angeles , Los AngelesPostdoctoral Fellow2016Immunotherapy and gene therapy for HIV
    University of California Los Angeles, Los AngelesProject Scientist 2020Immunotherapy for infectious disease and tumor

    Collapse Overview 
    Collapse Overview
    The development of biologics, including protein and gene agents, represents a major advancement towards better therapeutics with high potency and specificity. Their broader adoption, however, has been limited by factors such as undesired biodistribution, low stability, and immunogenicity. The Wen lab focuses on developing advanced biologics through nano-encapsulation and molecule-architecture design that mitigate such limitations, leading to various therapeutics for viral infection, central nervous system diseases (e.g., brain tumor, systemic tumor with brain metastases, and spinal cord injury), and cancers via immune modulation and other pathways.

    Collapse Research 
    Collapse Research Activities and Funding
    An antioxidant enzyme to suppress hyperinflammation induced by SARS-CoV-2
    NIH R56AI163386Aug 18, 2022 - Aug 17, 2023
    Role: Principal Investigator
    Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
    NIH R01DA052841Sep 30, 2020 - Jul 31, 2025
    Role: Co-Investigator
    Targeting delivery of mAbs to CNS metastases
    NIH R01CA253215Aug 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    (Attack)2: Genetic engineering of cellular and humoral immunity to cure HIV
    NIH U19AI149504May 7, 2020 - Apr 30, 2025
    Role: Co-Investigator
    In Vivo Gene Editing for HIV-1 Cure
    NIH R01AI145038Feb 11, 2019 - Jan 31, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy. Sci Transl Med. 2023 10 11; 15(717):eadd2712. Cao Z, Xu D, Harding J, Chen W, Liu X, Wang Z, Wang L, Qi T, Chen S, Guo X, Chen ISY, Guo J, Lu Y, Wen J. PMID: 37820006; PMCID: PMC10720694.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Efficacy of Antibodies Targeting TfR1 in Xenograft Mouse Models of AIDS-Related Non-Hodgkin Lymphoma. Cancers (Basel). 2023 Mar 17; 15(6). Daniels-Wells TR, Candelaria PV, Kranz E, Wen J, Wang L, Kamata M, Almagro JC, Martínez-Maza O, Penichet ML. PMID: 36980702; PMCID: PMC10046321.
      View in: PubMed   Mentions: 2  
    3. Rapid prototyping of functional acoustic devices using laser manufacturing. Lab Chip. 2022 11 08; 22(22):4327-4334. Zhang X, Son R, Lin YJ, Gill A, Chen S, Qi T, Choi D, Wen J, Lu Y, Lin NYC, Chiou PY. PMID: 36285690; PMCID: PMC10122935.
      View in: PubMed   Mentions: 1     Fields:    
    4. Reactive oxygen species associated immunoregulation post influenza virus infection. Front Immunol. 2022; 13:927593. Wang L, Cao Z, Wang Z, Guo J, Wen J. PMID: 35967412; PMCID: PMC9373727.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Targeted Nanocarrier Delivery of RNA Therapeutics to Control HIV Infection. Pharmaceutics. 2022 Jun 26; 14(7). Agbosu EE, Ledger S, Kelleher AD, Wen J, Ahlenstiel CL. PMID: 35890248; PMCID: PMC9324444.
      View in: PubMed   Mentions:
    6. Real-Time Quantification of Cell Internalization Kinetics by Bioluminescent Probes. Methods Mol Biol. 2022; 2525:93-107. Castillo R, Wu D, Cao Z, Yan R, Fajardo K, Ren J, Lu Y, Wen J. PMID: 35836062.
      View in: PubMed   Mentions:    Fields:    
    7. Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation. Adv Mater. 2022 Jan; 34(1):e2105670. Yan R, Ren J, Wen J, Cao Z, Wu D, Qin M, Xu D, Castillo R, Li F, Wang F, Gan Z, Liu C, Wei P, Lu Y. PMID: 34617335.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques. PLoS Pathog. 2021 07; 17(7):e1009738. Wen J, Cheever T, Wang L, Wu D, Reed J, Mascola J, Chen X, Liu C, Pegu A, Sacha JB, Lu Y, Haigwood NL, Chen ISY. PMID: 34283885; PMCID: PMC8323878.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model. J Immunother Cancer. 2021 02; 9(2). Wen J, Wang L, Ren J, Kranz E, Chen S, Wu D, Kanazawa T, Chen I, Lu Y, Kamata M. PMID: 33593826; PMCID: PMC7888328.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. An Antioxidant Enzyme Therapeutic for COVID-19. Adv Mater. 2020 Oct; 32(43):e2004901. Qin M, Cao Z, Wen J, Yu Q, Liu C, Wang F, Zhang J, Yang F, Li Y, Fishbein G, Yan S, Xu B, Hou Y, Ning Z, Nie K, Jiang N, Liu Z, Wu J, Yu Y, Li H, Zheng H, Li J, Jin W, Pang S, Wang S, Chen J, Gan Z, He Z, Lu Y. PMID: 32924219.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. The clonal repopulation of HSPC gene modified with anti-HIV-1 RNAi is not affected by preexisting HIV-1 infection. Sci Adv. 2020 07; 6(30):eaay9206. Suryawanshi GW, Khamaikawin W, Wen J, Shimizu S, Arokium H, Xie Y, Wang E, Kim S, Choi H, Zhang C, Yu H, Presson AP, Kim N, An DS, Chen ISY, Kim S. PMID: 32766447; PMCID: PMC7385479.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates. Front Immunol. 2019; 10:3132. Qin M, Wang L, Wu D, Williams CK, Xu D, Kranz E, Guo Q, Guan J, Vinters HV, Lee Y, Xie Y, Luo Y, Sun G, Sun X, He Z, Lu Y, Kamata M, Wen J, Chen ISY. PMID: 32047498; PMCID: PMC6996053.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    13. Real-Time Quantification of Cell Internalization Kinetics by Functionalized Bioluminescent Nanoprobes. Adv Mater. 2019 Sep; 31(39):e1902469. Wu D, Yang Y, Xu P, Xu D, Liu Y, Castillo R, Yan R, Ren J, Zhou G, Liu C, Qin M, Du J, Hou L, Chen I, Kang C, Jin L, Wen J, Chen W, Lu Y. PMID: 31402525.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    14. Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice. Nat Biomed Eng. 2019 09; 3(9):706-716. Wen J, Wu D, Qin M, Liu C, Wang L, Xu D, Vinters HV, Liu Y, Kranz E, Guan X, Sun G, Sun X, Lee Y, Martinez-Maza O, Widney D, Lu Y, Chen ISY, Kamata M. PMID: 31384008; PMCID: PMC6736720.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    15. Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration. Adv Mater. 2019 Aug; 31(33):e1900727. Xu D, Wu D, Qin M, Nih LR, Liu C, Cao Z, Ren J, Chen X, He Z, Yu W, Guan J, Duan S, Liu F, Liu X, Li J, Harley D, Xu B, Hou L, Chen ISY, Wen J, Chen W, Pourtaheri S, Lu Y. PMID: 31125138.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    16. A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System. Adv Mater. 2019 May; 31(18):e1807557. Wu D, Qin M, Xu D, Wang L, Liu C, Ren J, Zhou G, Chen C, Yang F, Li Y, Zhao Y, Huang R, Pourtaheri S, Kang C, Kamata M, Chen ISY, He Z, Wen J, Chen W, Lu Y. PMID: 30803073; PMCID: PMC6701476.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    17. Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy. Adv Mater. 2019 May; 31(19):e1805697. Han L, Liu C, Qi H, Zhou J, Wen J, Wu D, Xu D, Qin M, Ren J, Wang Q, Long L, Liu Y, Chen I, Yuan X, Lu Y, Kang C. PMID: 30773720.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    18. Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. Mol Ther Methods Clin Dev. 2018 Jun 15; 9:23-32. Khamaikawin W, Shimizu S, Kamata M, Cortado R, Jung Y, Lam J, Wen J, Kim P, Xie Y, Kim S, Arokium H, Presson AP, Chen ISY, An DS. PMID: 29322065; PMCID: PMC5751878.
      View in: PubMed   Mentions: 8  
    19. Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S59-S69. Chan J, Kim PY, Kranz E, Nagaoka Y, Lee Y, Wen J, Elsaesser HJ, Qin M, Brooks DG, Ringpis GE, Chen ISY, Kamata M. PMID: 29140111; PMCID: PMC5684681.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules. Chem Commun (Camb). 2016 Nov 15; 52(93):13608-13611. Li J, Zhang L, Liu Y, Wen J, Wu D, Xu D, Segura T, Jin J, Lu Y, Wang H. PMID: 27808287.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration. ACS Nano. 2016 08 23; 10(8):7362-9. Tian H, Du J, Wen J, Liu Y, Montgomery SR, Scott TP, Aghdasi B, Xiong C, Suzuki A, Hayashi T, Ruangchainikom M, Phan K, Weintraub G, Raed A, Murray SS, Daubs MD, Yang X, Yuan XB, Wang JC, Lu Y. PMID: 27227573.
      View in: PubMed   Mentions: 12     Fields:    
    22. Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules. PLoS One. 2016; 11(4):e0151572. Wen J, Yan M, Liu Y, Li J, Xie Y, Lu Y, Kamata M, Chen IS. PMID: 27049645; PMCID: PMC4822841.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs. PLoS One. 2015; 10(6):e0127986. Yan M, Wen J, Liang M, Lu Y, Kamata M, Chen IS. PMID: 26035832; PMCID: PMC4452785.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    24. Efficient delivery of therapeutic miRNA nanocapsules for tumor suppression. Adv Mater. 2015 Jan 14; 27(2):292-7. Liu C, Wen J, Meng Y, Zhang K, Zhu J, Ren Y, Qian X, Yuan X, Lu Y, Kang C. PMID: 25400269.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. Single siRNA nanocapsules for enhanced RNAi delivery. J Am Chem Soc. 2012 Aug 22; 134(33):13542-5. Yan M, Liang M, Wen J, Liu Y, Lu Y, Chen IS. PMID: 22866878; PMCID: PMC4318836.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    26. Controlled protein delivery based on enzyme-responsive nanocapsules. Adv Mater. 2011 Oct 18; 23(39):4549-53. Wen J, Anderson SM, Du J, Yan M, Wang J, Shen M, Lu Y, Segura T. PMID: 21910141; PMCID: PMC3263975.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    27. High-performance supercapacitors based on intertwined CNT/V2O5 nanowire nanocomposites. Adv Mater. 2011 Feb 08; 23(6):791-5. Chen Z, Augustyn V, Wen J, Zhang Y, Shen M, Dunn B, Lu Y. PMID: 21287644.
      View in: PubMed   Mentions: 29     Fields:    
    28. Single-crystal-like titania mesocages. Angew Chem Int Ed Engl. 2011 Feb 01; 50(5):1105-8. Bian Z, Zhu J, Wen J, Cao F, Huo Y, Qian X, Cao Y, Shen M, Li H, Lu Y. PMID: 21268205.
      View in: PubMed   Mentions: 3     Fields:    
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