Stephen G Young

Title(s)Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0001-7270-317 Additional info
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    Other Positions
    Title(s)Professor, Human Genetics


    Collapse Biography 
    Collapse Education and Training
    Princeton University, Princeton, NJ.AB1974History
    Washington University, St. Louis, MOMD1978Medicine
    UCSF, San Francisco1981Internal Medicine
    UCSD, La Jolla1983Cardiovascular Disease
    Collapse Awards and Honors
    2016National Academy of Sciences
    2021Corresponding Member Abroad of the Austrian Academy of Sciences
    2010Ernst Jung Prize in Medicine
    2009Doctor Honoris Causa (Medicine) University of Gothenburg, Sweden
    2021Inaugural Fellow of the American Society for Biochemistry and Molecular Biology
    2021Inaugural Fellow of the American Society for Biochemistry and Molecular Biology

    Collapse Overview 
    Collapse Overview
    Stephen Young grew up in Topeka, Kansas and studied history at Princeton University. After obtaining a medical degree from Washington University in St. Louis, he trained in internal medicine at UCSF and cardiology at UCSD. He did a postdoctoral research fellowship in lipid metabolism at UCSD with Dr. Joseph Witztum. After stints on the faculty at UCSD and UCSF (Gladstone Institutes), he moved to UCLA in 2004. Along with two UCLA faculty colleagues (Loren Fong and Anne Beigneux), he runs a research laboratory focused on plasma lipid metabolism and diseases of the nuclear envelope. Stephen Young is a member of the National Academy of Sciences. He also holds the Edward W. Carter Chair in Internal Medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    New approaches for understanding lipid movement in health and disease
    NIH P01HL146358May 1, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Investigating Mechanisms for Lipid Transport in Health and Disease
    NIH R35HL139725Jul 1, 2018 - Jun 30, 2025
    Role: Principal Investigator
    Defining mechanisms for lipid transport across capillary endothelial cells
    NIH R01HL125335Jul 2, 2015 - Apr 30, 2019
    Role: Principal Investigator
    ZMPSTE24, HIV treatment regimens, and atherosclerotic heart disease
    NIH R01HL126551Sep 12, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Antibodies to Define Molecular Mechanisms of Hypertriglyceridemia
    NIH RC1HL100008Sep 30, 2009 - Aug 31, 2011
    Role: Principal Investigator
    New Molecules in Triglyceride Metabolism and Adipogenesis
    NIH P01HL090553Dec 1, 2007 - Nov 30, 2019
    Role: Principal Investigator
    Refining Physiologic Mechanisms for Intravascular Triglyceride Metabolism
    NIH R01HL087228Feb 1, 2007 - May 31, 2025
    Role: Principal Investigator
    Hutchinson Gilford Progeria Syndrome and Atherosclerosis
    NIH R01HL076839Sep 1, 2005 - Aug 31, 2011
    Role: Principal Investigator
    CAAX Processing Enzymes as Anticancer Targets
    NIH R21CA103999Apr 1, 2004 - Mar 31, 2006
    Role: Principal Investigator
    Postisoprenylation Processing and the Nuclear Lamina
    NIH R01AR050200Sep 15, 2003 - Jun 30, 2009
    Role: Principal Investigator
    CaaX Protein Processing and Human Disease
    NIH R01AG035626Aug 15, 2003 - Jun 30, 2015
    Role: Principal Investigator
    CAAX Protein Processing and Cancer Therapy
    NIH R01CA099506Aug 1, 2003 - May 31, 2009
    Role: Principal Investigator
    NHLBI Bay Area Functional Genomics Consortium
    NIH U01HL066621Sep 30, 2000 - Jul 31, 2008
    Role: Principal Investigator
    THE NHLBI BAY AREA FUNCTIONAL GENOMICS COMSORTIUM
    NIH U01HL066590Sep 30, 2000 - Jul 31, 2005
    Role: Principal Investigator
    METABOLISM OF SPONTANEOUSLY DAMAGED PROTEINS IN AGING
    NIH R01AG015451Jul 1, 1998 - Jun 30, 2003
    Role: Principal Investigator
    LIPOPROTEIN STRUCTURE/FUNCTION IN CHOLESTEROL METABOLISM
    NIH P01HL041633Feb 1, 1989 - Jan 31, 2005
    Role: Principal Investigator
    HETEROGENEITY IN LOW DENSITY LIPOPROTEINS
    NIH K08HL001672Jan 1, 1986 - Dec 31, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Quantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay. J Lipid Res. 2024 Apr 11; 65(4):100532. Kimura T, Miyashita K, Fukamachi I, Fukamachi K, Ogura K, Yokoyama E, Tsunekawa K, Nagasawa T, Ploug M, Yang Y, Song W, Young SG, Beigneux AP, Nakajima K, Murakami M. PMID: 38608546.
      View in: PubMed   Mentions:
    2. T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption. bioRxiv. 2024 Mar 11. Gao Y, Kennelly JP, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen AH, Weston T, Uchiyama LF, Lee MS, Young SG, Bensinger SJ, Tontonoz P. PMID: 38559079; PMCID: PMC10979874.
      View in: PubMed   Mentions:
    3. Aster-B-dependent estradiol synthesis protects female mice from diet-induced obesity. J Clin Invest. 2024 Jan 04; 134(4). Xiao X, Kennelly JP, Feng AC, Cheng L, Romartinez-Alonso B, Bedard A, Gao Y, Cui L, Young SG, Schwabe JW, Tontonoz P. PMID: 38175723; PMCID: PMC10866650.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen. J Clin Invest. 2023 Dec 01; 133(23). Yang Y, Beigneux AP, Song W, Nguyen LP, Jung H, Tu Y, Weston TA, Tran CM, Xie K, Yu RG, Tran AP, Miyashita K, Nakajima K, Murakami M, Chen YQ, Zhen EY, Kim JR, Kim PH, Birrane G, Tontonoz P, Ploug M, Konrad RJ, Fong LG, Young SG. PMID: 37824203; PMCID: PMC10688983.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science. 2023 11 10; 382(6671):eadf0966. Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. PMID: 37943936.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Imaging the ANGPTL3/8-mediated regulation of lipoprotein lipase in the heart. J Lipid Res. 2023 12; 64(12):100467. Yang Y, Jung H, Konrad RJ, Fong LG, Young SG. PMID: 37898405; PMCID: PMC10755034.
      View in: PubMed   Mentions:    Fields:    
    7. The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing. Proc Natl Acad Sci U S A. 2023 Oct 31; 120(44):e2313825120. Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen LP, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane G, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. PMID: 37871217; PMCID: PMC10623010.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice. Nucleus. 2023 12; 14(1):2262308. Kim JR, Kim PH, Presnell A, Tu Y, Young SG. PMID: 37754663; PMCID: PMC10538457.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake. bioRxiv. 2023 Jul 10. Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. PMID: 37503112; PMCID: PMC10369906.
      View in: PubMed   Mentions:
    10. Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase. Proc Natl Acad Sci U S A. 2023 05 02; 120(18):e2221888120. Kumari A, Grønnemose AL, Kristensen KK, Winther AL, Young SG, Jørgensen TJD, Ploug M. PMID: 37094117; PMCID: PMC10160976.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    11. Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2219833120. Song W, Yang Y, Heizer P, Tu Y, Weston TA, Kim JR, Munguia P, Jung H, Fong JL, Tran C, Ploug M, Beigneux AP, Young SG, Fong LG. PMID: 36787365; PMCID: PMC9974459.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat Metab. 2023 01; 5(1):165-181. Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. PMID: 36646756; PMCID: PMC9995220.
      View in: PubMed   Mentions: 4     Fields:    
    13. CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization. Nature. 2023 01; 613(7942):160-168. Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, Lin CH, Jin B, DeNardo LA, Black DL, Whitelegge JP, Wohlschlegel JA, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Tontonoz P. PMID: 36477540; PMCID: PMC9995219.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Subcellular Partitioning of Arsenic Trioxide Revealed by Label-Free Imaging. Anal Chem. 2022 10 11; 94(40):13889-13896. Huang S, Chen K, Leung JK, Guagliardo P, Chen W, Song W, Clode P, Xu J, Young SG, Jiang H. PMID: 36189785.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. NanoSIMS imaging of lipid absorption by intestinal enterocytes. J Lipid Res. 2022 11; 63(11):100290. Chen K, Song W, Russell R, Ferrari A, Darwish T, Tontonoz P, Young SG, Jiang H. PMID: 36179912; PMCID: PMC9672438.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2211136119. Young SG, Song W, Yang Y, Birrane G, Jiang H, Beigneux AP, Ploug M, Fong LG. PMID: 36037340; PMCID: PMC9457329.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells. J Clin Invest. 2022 03 01; 132(5). Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. PMID: 35229724; PMCID: PMC8884915.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. The zinc finger and BTB domain containing protein ZBTB20 regulates plasma triglyceride metabolism by repressing lipoprotein lipase gene transcription in hepatocytes. Hepatology. 2022 05; 75(5):1169-1180. Li H, Liu G, Wan X, Zhou L, Qin ZB, Ma XH, Su K, Liu YJ, Yuan J, Wei CC, Ren AJ, Chen YX, Young SG, Zhang H, Xie Z, Zhang WJ. PMID: 34580885; PMCID: PMC9118135.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome. JCI Insight. 2021 08 23; 6(16). Kim PH, Chen NY, Heizer PJ, Tu Y, Weston TA, Fong JL, Gill NK, Rowat AC, Young SG, Fong LG. PMID: 34423791; PMCID: PMC8409987.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity. Front Cell Dev Biol. 2021; 9:702508. Kristensen KK, Leth-Espensen KZ, Kumari A, Grønnemose AL, Lund-Winther AM, Young SG, Ploug M. PMID: 34336854; PMCID: PMC8319833.
      View in: PubMed   Mentions: 14  
    21. Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts. Proc Natl Acad Sci U S A. 2021 06 22; 118(25). Chen NY, Kim PH, Tu Y, Yang Y, Heizer PJ, Young SG, Fong LG. PMID: 34161290; PMCID: PMC8237679.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding. J Lipid Res. 2021; 62:100071. Lund Winther AM, Kumari A, Young SG, Ploug M. PMID: 33771536; PMCID: PMC8175412.
      View in: PubMed   Mentions: 4     Fields:    
    23. The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). Leth-Espensen KZ, Kristensen KK, Kumari A, Winther AL, Young SG, Jørgensen TJD, Ploug M. PMID: 33723082; PMCID: PMC8000434.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    24. High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS). Nucleic Acids Res. 2021 01 11; 49(1):1-14. He C, Migawa MT, Chen K, Weston TA, Tanowitz M, Song W, Guagliardo P, Iyer KS, Bennett CF, Fong LG, Seth PP, Young SG, Jiang H. PMID: 33275144; PMCID: PMC7797060.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies. Nucleus. 2020 12; 11(1):237-249. Chen NY, Kim PH, Fong LG, Young SG. PMID: 32910721; PMCID: PMC7529418.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Chylomicronemia from GPIHBP1 autoantibodies. J Lipid Res. 2020 11; 61(11):1365-1376. Miyashita K, Lutz J, Hudgins LC, Toib D, Ashraf AP, Song W, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32948662; PMCID: PMC7604722.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    27. Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane. Mol Cell Biol. 2020 09 14; 40(19). Ferrari A, He C, Kennelly JP, Sandhu J, Xiao X, Chi X, Jiang H, Young SG, Tontonoz P. PMID: 32719109; PMCID: PMC7491948.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report. Ann Intern Med. 2020 11 03; 173(9):764-765. Lutz J, Dunaj-Kazmierowska M, Arcan S, Kassner U, Miyashita K, Murakami M, Ploug M, Fong LG, Young SG, Nakajima K, Beigneux AP. PMID: 32777186; PMCID: PMC8174005.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. J Lipid Res. 2020 10; 61(10):1347-1359. Luz JG, Beigneux AP, Asamoto DK, He C, Song W, Allan CM, Morales J, Tu Y, Kwok A, Cottle T, Meiyappan M, Fong LG, Kim JE, Ploug M, Young SG, Birrane G. PMID: 32690595; PMCID: PMC7529051.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. Peroxidasin-mediated bromine enrichment of basement membranes. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15827-15836. He C, Song W, Weston TA, Tran C, Kurtz I, Zuckerman JE, Guagliardo P, Miner JH, Ivanov SV, Bougoure J, Hudson BG, Colon S, Voziyan PA, Bhave G, Fong LG, Young SG, Jiang H. PMID: 32571911; PMCID: PMC7354931.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    31. Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10976-10982. Belling JN, Heidenreich LK, Tian Z, Mendoza AM, Chiou TT, Gong Y, Chen NY, Young TD, Wattanatorn N, Park JH, Scarabelli L, Chiang N, Takahashi J, Young SG, Stieg AZ, De Oliveira S, Huang TJ, Weiss PS, Jonas SJ. PMID: 32358194; PMCID: PMC7245081.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    32. Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10476-10483. He C, Jiang H, Song W, Riezman H, Tontonoz P, Weston TA, Guagliardo P, Kim PH, Jung R, Heizer P, Fong LG, Young SG. PMID: 32354992; PMCID: PMC7229689.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    33. ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain. J Lipid Res. 2020 09; 61(9):1253. Kristensen KK, Leth-Espensen KZ, Young SG, Ploug M. PMID: 32327484; PMCID: PMC7469884.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    34. The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes. J Lipid Res. 2020 06; 61(6):815. Jiang H, He C, Fong LG, Young SG. PMID: 32241805; PMCID: PMC7269765.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid. Front Cell Dev Biol. 2020; 8:144. Van Veldhoven PP, de Schryver E, Young SG, Zwijsen A, Fransen M, Espeel M, Baes M, Van Ael E. PMID: 32266253; PMCID: PMC7106852.
      View in: PubMed   Mentions: 12  
    36. Images in Lipid Research. J Lipid Res. 2020 05; 61(5):589-590. Young SG. PMID: 32132143; PMCID: PMC7193954.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells. J Lipid Res. 2020 05; 61(5):591. Meng X, Zeng W, Young SG, Fong LG. PMID: 32132144; PMCID: PMC7193966.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    38. Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4337-4346. Kristensen KK, Leth-Espensen KZ, Mertens HDT, Birrane G, Meiyappan M, Olivecrona G, Jørgensen TJD, Young SG, Ploug M. PMID: 32034094; PMCID: PMC7049152.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    39. Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies. J Clin Lipidol. 2020 Mar - Apr; 14(2):197-200. Ashraf AP, Miyashita K, Nakajima K, Murakami M, Hegele RA, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 32107180; PMCID: PMC7166156.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    40. Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores. J Lipid Res. 2020 03; 61(3):413-421. Heizer PJ, Yang Y, Tu Y, Kim PH, Chen NY, Hu Y, Yoshinaga Y, de Jong PJ, Vergnes L, Morales JE, Li RL, Jackson N, Reue K, Young SG, Fong LG. PMID: 31941672; PMCID: PMC7053845.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    41. An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death. Proc Natl Acad Sci U S A. 2019 12 17; 116(51):25870-25879. Chen NY, Yang Y, Weston TA, Belling JN, Heizer P, Tu Y, Kim P, Edillo L, Jonas SJ, Weiss PS, Fong LG, Young SG. PMID: 31796586; PMCID: PMC6926041.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    42. Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. Elife. 2019 09 05; 8. Hu X, Weston TA, He C, Jung RS, Heizer PJ, Young BD, Tu Y, Tontonoz P, Wohlschlegel JA, Jiang H, Young SG, Fong LG. PMID: 31486771; PMCID: PMC6750930.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    43. GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Cell Metab. 2019 07 02; 30(1):51-65. Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. PMID: 31269429; PMCID: PMC6662658.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    44. DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces. Front Cell Dev Biol. 2019; 7:103. Gill NK, Ly C, Kim PH, Saunders CA, Fong LG, Young SG, Luxton GWG, Rowat AC. PMID: 31294022; PMCID: PMC6606767.
      View in: PubMed   Mentions: 7  
    45. GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients. Elife. 2019 06 06; 8. Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H. PMID: 31169500; PMCID: PMC6594755.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    46. Evolution and Medical Significance of LU Domain-Containing Proteins. Int J Mol Sci. 2019 Jun 05; 20(11). Leth JM, Leth-Espensen KZ, Kristensen KK, Kumari A, Lund Winther AM, Young SG, Ploug M. PMID: 31195646; PMCID: PMC6600238.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    47. Lipoprotein lipase is active as a monomer. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6319-6328. Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. PMID: 30850549; PMCID: PMC6442593.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    48. Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina. Proc Natl Acad Sci U S A. 2019 03 05; 116(10):4307-4315. Nmezi B, Xu J, Fu R, Armiger TJ, Rodriguez-Bey G, Powell JS, Ma H, Sullivan M, Tu Y, Chen NY, Young SG, Stolz DB, Dahl KN, Liu Y, Padiath QS. PMID: 30765529; PMCID: PMC6410836.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    49. An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner. J Lipid Res. 2019 04; 60(4):869-879. Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG. PMID: 30598475; PMCID: PMC6446700.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    50. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1723-1732. Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. PMID: 30559189; PMCID: PMC6358717.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    51. Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. J Clin Invest. 2019 01 02; 129(1):281-295. Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K. PMID: 30507612; PMCID: PMC6307960.
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    52. GPIHBP1 autoantibody syndrome during interferon β1a treatment. J Clin Lipidol. 2019 Jan - Feb; 13(1):62-69. Eguchi J, Miyashita K, Fukamachi I, Nakajima K, Murakami M, Kawahara Y, Yamashita T, Ohta Y, Abe K, Nakatsuka A, Mino M, Takase S, Okazaki H, Hegele RA, Ploug M, Hu X, Wada J, Young SG, Beigneux AP. PMID: 30514621; PMCID: PMC6379125.
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    53. Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness. JCI Insight. 2018 10 04; 3(19). Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J. PMID: 30282816; PMCID: PMC6237469.
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    54. An ELISA for quantifying GPIHBP1 autoantibodies and making a diagnosis of the GPIHBP1 autoantibody syndrome. Clin Chim Acta. 2018 Dec; 487:174-178. Miyashita K, Fukamachi I, Machida T, Nakajima K, Young SG, Murakami M, Beigneux AP, Nakajima K. PMID: 30287259; PMCID: PMC6349362.
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    55. Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. Sci Transl Med. 2018 09 26; 10(460). Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG. PMID: 30257952; PMCID: PMC6166472.
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    56. Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10100-10105. Chen NY, Kim P, Weston TA, Edillo L, Tu Y, Fong LG, Young SG. PMID: 30224463; PMCID: PMC6176609.
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    57. NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes. Biochem Biophys Res Commun. 2018 10 12; 504(4):899-902. He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H. PMID: 30224066; PMCID: PMC6476570.
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    58. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell. 2018 10 04; 175(2):514-529.e20. Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P. PMID: 30220461; PMCID: PMC6469685.
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    59. Macrophages release plasma membrane-derived particles rich in accessible cholesterol. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8499-E8508. He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. PMID: 30127022; PMCID: PMC6130402.
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    60. A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):E6020-E6029. Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M. PMID: 29899144; PMCID: PMC6042107.
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    61. NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes. Cell Metab. 2018 May 01; 27(5):1055-1066.e3. He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H. PMID: 29719224; PMCID: PMC5945212.
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    62. Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure. J Lipid Res. 2018 04; 59(4):706-713. Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG. PMID: 29449313; PMCID: PMC5880501.
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    63. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. PMID: 29249357; PMCID: PMC5766418.
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    64. An enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum. J Clin Lipidol. 2018 Jan - Feb; 12(1):203-210.e1. Miyashita K, Fukamachi I, Nagao M, Ishida T, Kobayashi J, Machida T, Nakajima K, Murakami M, Ploug M, Beigneux AP, Young SG, Nakajima K. PMID: 29246728; PMCID: PMC5963937.
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    65. Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1. JCI Insight. 2017 10 19; 2(20). He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG. PMID: 29046479; PMCID: PMC5846916.
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    66. Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice. J Dermatol Sci. 2018 Jan; 89(1):85-87. Allan CM, Heizer PJ, Jung CJ, Tu Y, Tran D, Young LC, Fong LG, de Jong PJ, Beigneux AP, Young SG. PMID: 29017797; PMCID: PMC6108176.
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    67. A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency. Exp Dermatol. 2017 11; 26(11):1134-1136. Allan CM, Tran D, Tu Y, Heizer PJ, Young LC, Fong LG, Beigneux AP, Young SG. PMID: 28418591; PMCID: PMC5705011.
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    68. Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL. J Lipid Res. 2017 09; 58(9):1893-1902. Larsson M, Allan CM, Jung RS, Heizer PJ, Beigneux AP, Young SG, Fong LG. PMID: 28694296; PMCID: PMC5580902.
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    69. GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia. J Clin Lipidol. 2017 Jul - Aug; 11(4):964-971. Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP. PMID: 28666713; PMCID: PMC5568906.
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    70. Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding. J Lipid Res. 2017 07; 58(7):1453-1461. Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG. PMID: 28476858; PMCID: PMC5496041.
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    71. Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation. Nat Commun. 2017 04 20; 8:15098. Gigante CM, Dibattista M, Dong FN, Zheng X, Yue S, Young SG, Reisert J, Zheng Y, Zhao H. PMID: 28425486; PMCID: PMC5411488.
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    72. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. N Engl J Med. 2017 04 27; 376(17):1647-1658. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. PMID: 28402248; PMCID: PMC5555413.
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    73. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. J Clin Invest. 2017 Mar 01; 127(3):987-1004. Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P. PMID: 28192372; PMCID: PMC5330726.
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    74. High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2000-2005. He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H. PMID: 28167768; PMCID: PMC5338444.
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    75. The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding. Elife. 2016 12 08; 5. Mysling S, Kristensen KK, Larsson M, Kovrov O, Bensadouen A, Jørgensen TJ, Olivecrona G, Young SG, Ploug M. PMID: 27929370; PMCID: PMC5148603.
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    76. Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL. J Lipid Res. 2017 01; 58(1):208-215. Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 27875259; PMCID: PMC5234723.
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    77. Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries. J Lipid Res. 2017 01; 58(1):216-225. Allan CM, Larsson M, Jung RS, Ploug M, Bensadoun A, Beigneux AP, Fong LG, Young SG. PMID: 27811232; PMCID: PMC5234724.
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    78. NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues. J Investig Med. 2017 03; 65(3):669-672. He C, Fong LG, Young SG, Jiang H. PMID: 27793974; PMCID: PMC5493309.
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    79. LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A. Nucleus. 2016 Sep 02; 7(5):512-521. Tu Y, Sánchez-Iglesias S, Araújo-Vilar D, Fong LG, Young SG. PMID: 27841971; PMCID: PMC5120598.
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    80. Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. Nat Chem. 2016 12; 8(12):1152-1158. Mehmood S, Marcoux J, Gault J, Quigley A, Michaelis S, Young SG, Carpenter EP, Robinson CV. PMID: 27874871; PMCID: PMC5123592.
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    81. An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1. J Lipid Res. 2016 10; 57(10):1889-1898. Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. PMID: 27494936; PMCID: PMC5036369.
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    82. GPIHBP1 and Plasma Triglyceride Metabolism. Trends Endocrinol Metab. 2016 07; 27(7):455-469. Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M. PMID: 27185325; PMCID: PMC4927088.
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    83. Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor Function. J Neurosci. 2016 05 04; 36(18):5107-14. Christiansen JR, Pendse ND, Kolandaivelu S, Bergo MO, Young SG, Ramamurthy V. PMID: 27147662; PMCID: PMC4854971.
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    84. Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development. Mol Biol Cell. 2016 06 15; 27(12):1928-37. Razafsky D, Ward C, Potter C, Zhu W, Xue Y, Kefalov VJ, Fong LG, Young SG, Hodzic D. PMID: 27075175; PMCID: PMC4907726.
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    85. Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes. J Lipid Res. 2016 09; 57(9):1670-83. Dijk W, Beigneux AP, Larsson M, Bensadoun A, Young SG, Kersten S. PMID: 27034464; PMCID: PMC5003152.
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    86. Modulation of LMNA splicing as a strategy to treat prelamin A diseases. J Clin Invest. 2016 Apr 01; 126(4):1592-602. Lee JM, Nobumori C, Tu Y, Choi C, Yang SH, Jung HJ, Vickers TA, Rigo F, Bennett CF, Young SG, Fong LG. PMID: 26999604; PMCID: PMC4811112.
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    87. The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. Elife. 2016 Jan 03; 5:e12095. Mysling S, Kristensen KK, Larsson M, Beigneux AP, Gårdsvoll H, Fong LG, Bensadouen A, Jørgensen TJ, Young SG, Ploug M. PMID: 26725083; PMCID: PMC4755760.
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    88. SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res. 2016 Mar; 57(3):410-21. Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K. PMID: 26685326; PMCID: PMC4766990.
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    89. Palmoplantar Keratoderma in Slurp2-Deficient Mice. J Invest Dermatol. 2016 Feb; 136(2):436-443. Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP. PMID: 26967477; PMCID: PMC4789766.
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    90. JCL Roundtable: Hypertriglyceridemia due to defects in lipoprotein lipase function. J Clin Lipidol. 2015 May-Jun; 9(3):274-80. Brown WV, Goldberg IJ, Young SG. PMID: 26073384; PMCID: PMC4578811.
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    91. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015 Mar 25; 4. Rong X, Wang B, Dunham MM, Hedde PN, Wong JS, Gratton E, Young SG, Ford DA, Tontonoz P. PMID: 25806685; PMCID: PMC4400582.
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    92. Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015; 10(3):e0116196. Tapia O, Fong LG, Huber MD, Young SG, Gerace L. PMID: 25790465; PMCID: PMC4366207.
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    93. Mice that express farnesylated versions of prelamin A in neurons develop achalasia. Hum Mol Genet. 2015 May 15; 24(10):2826-40. Yang SH, Procaccia S, Jung HJ, Nobumori C, Tatar A, Tu Y, Bayguinov YR, Hwang SJ, Tran D, Ward SM, Fong LG, Young SG. PMID: 25652409; PMCID: PMC4406294.
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    94. GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding. Circ Res. 2015 Feb 13; 116(4):624-32. Beigneux AP, Fong LG, Bensadoun A, Davies BS, Oberer M, Gårdsvoll H, Ploug M, Young SG. PMID: 25387803; PMCID: PMC4329087.
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    95. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metab. 2014 Nov 04; 20(5):910-918. Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P. PMID: 25440061; PMCID: PMC4261644.
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    96. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014 Dec; 124(12):5368-84. Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD. PMID: 25347472; PMCID: PMC4348973.
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    97. An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Mol Cell Biol. 2014 Dec; 34(24):4534-44. Jung HJ, Tatar A, Tu Y, Nobumori C, Yang SH, Goulbourne CN, Herrmann H, Fong LG, Young SG. PMID: 25312645; PMCID: PMC4248738.
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    98. High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. J Lipid Res. 2014 Oct; 55(10):2156-66. Jiang H, Goulbourne CN, Tatar A, Turlo K, Wu D, Beigneux AP, Grovenor CR, Fong LG, Young SG. PMID: 25143463; PMCID: PMC4174007.
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    99. Do lamin B1 and lamin B2 have redundant functions? Nucleus. 2014 Jul-Aug; 5(4):287-92. Lee JM, Jung HJ, Fong LG, Young SG. PMID: 25482116; PMCID: PMC4152341.
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    100. Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain. J Biol Chem. 2014 Jul 11; 289(28):19491-9. Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gårdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP. PMID: 24847059; PMCID: PMC4094059.
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    101. Nuclear lamins and neurobiology. Mol Cell Biol. 2014 Aug; 34(15):2776-85. Young SG, Jung HJ, Lee JM, Fong LG. PMID: 24842906; PMCID: PMC4135577.
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    102. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. PMID: 24726386; PMCID: PMC4143151.
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    103. Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter. Biochim Biophys Acta. 2014 Jul; 1841(7):963-9. Turlo K, Leung CS, Seo JJ, Goulbourne CN, Adeyo O, Gin P, Voss C, Bensadoun A, Fong LG, Young SG, Beigneux AP. PMID: 24704550; PMCID: PMC4212522.
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    104. A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase. Biochim Biophys Acta. 2014 Jul; 1841(7):970-6. Bensadoun A, Mottler CD, Pelletier C, Wu D, Seo JJ, Leung CS, Adeyo O, Goulbourne CN, Gin P, Fong LG, Young SG, Beigneux AP. PMID: 24681165; PMCID: PMC4222086.
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    105. Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014 May; 25(10):1666-75. Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG. PMID: 24672053; PMCID: PMC4019497.
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    106. Response to Gerlic et al. Cell Metab. 2014 Mar 04; 19(3):346-7. Im SS, Young SG, Raffatellu M, Osborne TF. PMID: 24606892.
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    107. Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun; 134(6):1589-1598. Adeyo O, Allan BB, Barnes RH, Goulbourne CN, Tatar A, Tu Y, Young LC, Weinstein MM, Tontonoz P, Fong LG, Beigneux AP, Young SG. PMID: 24499735; PMCID: PMC4214150.
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    108. Lipin-1 and lipin-3 together determine adiposity in vivo. Mol Metab. 2014 Apr; 3(2):145-54. Csaki LS, Dwyer JR, Li X, Nguyen MH, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong L, Young SG, Reue K. PMID: 24634820; PMCID: PMC3953701.
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    109. New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome. Hum Mol Genet. 2014 Mar 15; 23(6):1506-15. Jung HJ, Tu Y, Yang SH, Tatar A, Nobumori C, Wu D, Young SG, Fong LG. PMID: 24203701; PMCID: PMC3929089.
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    110. Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. PLoS One. 2013; 8(6):e65967. MacKay KB, Tu Y, Young SG, Clarke SG. PMID: 23840384; PMCID: PMC3688711.
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    111. Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science. 2013 Jun 14; 340(6138):1330-3. Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, Bergo MO. PMID: 23686339; PMCID: PMC4295631.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    112. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):E1923-32. Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG. PMID: 23650370; PMCID: PMC3666708.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    113. Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res. 2013 Jul; 52(3):305-16. Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K. PMID: 23603613; PMCID: PMC3830937.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    114. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Elife. 2013 Apr 09; 2:e00444. Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D. PMID: 23580231; PMCID: PMC3622177.
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    115. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 05; 17(3):423-35. Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 23473036; PMCID: PMC3626567.
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    116. Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev. 2013 Mar 01; 27(5):459-84. Young SG, Zechner R. PMID: 23475957; PMCID: PMC3605461.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    117. Targeting protein prenylation in progeria. Sci Transl Med. 2013 Feb 06; 5(171):171ps3. Young SG, Yang SH, Davies BS, Jung HJ, Fong LG. PMID: 23390246; PMCID: PMC3725554.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    118. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol. 2013 Apr; 33(8):1503-14. Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. PMID: 23382078; PMCID: PMC3624246.
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    119. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation. 2013 Feb 19; 127(7):782-90. Khan OM, Akula MK, Skålen K, Karlsson C, Ståhlman M, Young SG, Borén J, Bergo MO. PMID: 23334894; PMCID: PMC3940160.
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    120. Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency. BMC Physiol. 2012 Nov 27; 12:14. Nyrén R, Chang CL, Lindström P, Barmina A, Vorrsjö E, Ali Y, Juntti-Berggren L, Bensadoun A, Young SG, Olivecrona T, Olivecrona G. PMID: 23186339; PMCID: PMC3537605.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    121. Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One. 2012; 7(10):e47196. Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S. PMID: 23077570; PMCID: PMC3471957.
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    122. Nuclear lamins in the brain - new insights into function and regulation. Mol Neurobiol. 2013 Feb; 47(1):290-301. Jung HJ, Lee JM, Yang SH, Young SG, Fong LG. PMID: 23065386; PMCID: PMC3538886.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    123. Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. J Lipid Res. 2012 Dec; 53(12):2690-7. Davies BS, Goulbourne CN, Barnes RH, Turlo KA, Gin P, Vaughan S, Vaux DJ, Bensadoun A, Beigneux AP, Fong LG, Young SG. PMID: 23008484; PMCID: PMC3494248.
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    124. Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2541-6. Zhang L, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 22936343; PMCID: PMC4280256.
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    125. Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):E2486-95. Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K. PMID: 22908270; PMCID: PMC3443145.
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    126. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res. 2012 Sep; 53(9):1920-31. Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD. PMID: 22781001; PMCID: PMC3413231.
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    127. Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Hum Mol Genet. 2012 Jul 01; 21(13):2961-72. Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BS, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG. PMID: 22493000; PMCID: PMC3373243.
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    128. Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. J Lipid Res. 2012 Jun; 53(6):1176-82. Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG. PMID: 22448028; PMCID: PMC3351824.
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    129. Lowering plasma cholesterol by raising LDL receptors--revisited. N Engl J Med. 2012 Mar 22; 366(12):1154-5. Young SG, Fong LG. PMID: 22435375; PMCID: PMC5611813.
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    130. Understanding the roles of nuclear A- and B-type lamins in brain development. J Biol Chem. 2012 May 11; 287(20):16103-10. Young SG, Jung HJ, Coffinier C, Fong LG. PMID: 22416132; PMCID: PMC3351360.
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    131. New wrinkles in lipoprotein lipase biology. Curr Opin Lipidol. 2012 Feb; 23(1):35-42. Davies BS, Beigneux AP, Fong LG, Young SG. PMID: 22123668; PMCID: PMC3383841.
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    132. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):E423-31. Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BS, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG. PMID: 22308344; PMCID: PMC3289373.
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    133. Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):230-5. Weinstein MM, Goulbourne CN, Davies BS, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG. PMID: 22173228; PMCID: PMC3281771.
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    134. Are B-type lamins essential in all mammalian cells? Nucleus. 2011 Nov-Dec; 2(6):562-9. Yang SH, Jung HJ, Coffinier C, Fong LG, Young SG. PMID: 22127257; PMCID: PMC3324344.
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    135. Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. J Lipid Res. 2012 Jan; 53(1):77-86. Yang SH, Chang SY, Tu Y, Lawson GW, Bergo MO, Fong LG, Young SG. PMID: 22039581; PMCID: PMC3243483.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    136. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 2011 Nov 02; 14(5):671-83. Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT. PMID: 21982743; PMCID: PMC3216113.
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    137. Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell. 2011 Dec; 22(23):4683-93. Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG. PMID: 21976703; PMCID: PMC3226484.
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    138. GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res. 2011 Nov; 52(11):1869-84. Young SG, Davies BS, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP. PMID: 21844202; PMCID: PMC3196223.
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    139. An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Hum Mol Genet. 2011 Sep 15; 20(18):3537-44. Yang SH, Chang SY, Yin L, Tu Y, Hu Y, Yoshinaga Y, de Jong PJ, Fong LG, Young SG. PMID: 21659336; PMCID: PMC3159554.
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    140. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab. 2011 May 04; 13(5):540-9. Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF. PMID: 21531336; PMCID: PMC3090630.
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    141. Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7980-4. Voss CV, Davies BS, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG. PMID: 21518912; PMCID: PMC3093490.
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    142. Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase. J Biol Chem. 2011 Jun 03; 286(22):19735-43. Beigneux AP, Davies BS, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG. PMID: 21478160; PMCID: PMC3103352.
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    143. Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4997-5002. Verstraeten VL, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J. PMID: 21383178; PMCID: PMC3064351.
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    144. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol. 2011 May; 31(9):1885-93. Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P. PMID: 21343340; PMCID: PMC3133228.
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    145. Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques. Circulation. 2011 Mar 08; 123(9):989-98. Feig JE, Parathath S, Rong JX, Mick SL, Vengrenyuk Y, Grauer L, Young SG, Fisher EA. PMID: 21339485; PMCID: PMC3131163.
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    146. Investigating the purpose of prelamin A processing. Nucleus. 2011 Jan-Feb; 2(1):4-9. Davies BS, Coffinier C, Yang SH, Barnes RH, Jung HJ, Young SG, Fong LG. PMID: 21647293; PMCID: PMC3104803.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    147. Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Hum Mol Genet. 2011 Feb 01; 20(3):436-44. Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG. PMID: 21088111; PMCID: PMC3016906.
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    148. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010 Nov 10; 5(11):e13919. Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS. PMID: 21085708; PMCID: PMC2978080.
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    149. Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. J Biol Chem. 2011 Jan 07; 286(1):380-90. Vergnes L, Chin R, Young SG, Reue K. PMID: 21044951; PMCID: PMC3012996.
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    150. Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2504-9. Shu X, Nelbach L, Weinstein MM, Burgess BL, Beckstead JA, Young SG, Ryan RO, Forte TM. PMID: 20966404; PMCID: PMC2988087.
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    151. Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):176-82. Gin P, Beigneux AP, Voss C, Davies BS, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 20966398; PMCID: PMC3004026.
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    152. Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. J Biol Chem. 2010 Dec 10; 285(50):39239-48. Olafsen T, Young SG, Davies BS, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG. PMID: 20889497; PMCID: PMC2998116.
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    153. Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria. Dev Cell. 2010 Sep 14; 19(3):413-25. Hernandez L, Roux KJ, Wong ES, Mounkes LC, Mutalif R, Navasankari R, Rai B, Cool S, Jeong JW, Wang H, Lee HS, Kozlov S, Grunert M, Keeble T, Jones CM, Meta MD, Young SG, Daar IO, Burke B, Perantoni AO, Stewart CL. PMID: 20833363; PMCID: PMC2953243.
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    154. Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2106-13. Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG. PMID: 20814015; PMCID: PMC2959134.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    155. LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. Nucleus. 2010 Sep-Oct; 1(5):407-11. Coffinier C, Fong LG, Young SG. PMID: 21278813; PMCID: PMC3027074.
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    156. GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab. 2010 Jul 07; 12(1):42-52. Davies BS, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG. PMID: 20620994; PMCID: PMC2913606.
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    157. Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010 Jul 02; 285(27):20818-26. Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG. PMID: 20439468; PMCID: PMC2898298.
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    158. An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet. 2010 Jul 01; 19(13):2682-94. Davies BS, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG. PMID: 20421363; PMCID: PMC2883346.
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    159. Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6471-6. Liu M, Sjogren AK, Karlsson C, Ibrahim MX, Andersson KM, Olofsson FJ, Wahlstrom AM, Dalin M, Yu H, Chen Z, Yang SH, Young SG, Bergo MO. PMID: 20308544; PMCID: PMC2852017.
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    160. Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5076-81. Coffinier C, Chang SY, Nobumori C, Tu Y, Farber EA, Toth JI, Fong LG, Young SG. PMID: 20145110; PMCID: PMC2841930.
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    161. Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects. Circ Cardiovasc Genet. 2010 Apr; 3(2):169-78. Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel AW, Bensadoun A, Kastelein JJ, Fong LG, Dallinga-Thie GM, Beigneux AP. PMID: 20124439; PMCID: PMC2858258.
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    162. Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet. 2010 Apr 15; 19(8):1603-17. Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG. PMID: 20106865; PMCID: PMC2846164.
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    163. Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia. J Lipid Res. 2010 Jun; 51(6):1535-45. Olivecrona G, Ehrenborg E, Semb H, Makoveichuk E, Lindberg A, Hayden MR, Gin P, Davies BS, Weinstein MM, Fong LG, Beigneux AP, Young SG, Olivecrona T, Hernell O. PMID: 20026666; PMCID: PMC3035517.
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    164. Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria. J Lipid Res. 2010 Feb; 51(2):400-5. Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG. PMID: 19965595; PMCID: PMC2803242.
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    165. Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):20-3. Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG. PMID: 19815815; PMCID: PMC2796285.
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    166. A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis. 2009 Oct; 30(20):3598-606. Chan LN, Hart C, Guo L, Nyberg T, Davies BS, Fong LG, Young SG, Agnew BJ, Tamanoi F. PMID: 19784953; PMCID: PMC2855049.
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    167. Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase. J Biol Chem. 2009 Oct 30; 284(44):30240-7. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Fong LG, Young SG. PMID: 19726683; PMCID: PMC2781579.
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    168. Biventricular adaptation to volume overload in mice with aortic regurgitation. J Cardiovasc Magn Reson. 2009 Aug 11; 11:27. Berry CJ, Miller JD, McGroary K, Thedens DR, Young SG, Heistad DD, Weiss RM. PMID: 19671155; PMCID: PMC2731737.
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    169. Laminopathies and the long strange trip from basic cell biology to therapy. J Clin Invest. 2009 Jul; 119(7):1825-36. Worman HJ, Fong LG, Muchir A, Young SG. PMID: 19587457; PMCID: PMC2701866.
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    170. Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Mol Cell Biol. 2009 Sep; 29(17):4864-72. Im SS, Hammond LE, Yousef L, Nugas-Selby C, Shin DJ, Seo YK, Fong LG, Young SG, Osborne TF. PMID: 19564420; PMCID: PMC2725716.
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    171. GPIHBP1 and lipolysis: an update. Curr Opin Lipidol. 2009 Jun; 20(3):211-6. Beigneux AP, Weinstein MM, Davies BS, Gin P, Bensadoun A, Fong LG, Young SG. PMID: 19369870; PMCID: PMC2810420.
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    172. The small molecule phenamil induces osteoblast differentiation and mineralization. Mol Cell Biol. 2009 Jul; 29(14):3905-14. Park KW, Waki H, Kim WK, Davies BS, Young SG, Parhami F, Tontonoz P. PMID: 19433444; PMCID: PMC2704753.
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    173. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation. 2009 May 26; 119(20):2693-701. Miller JD, Weiss RM, Serrano KM, Brooks RM, Berry CJ, Zimmerman K, Young SG, Heistad DD. PMID: 19433756; PMCID: PMC2740986.
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    174. Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides. Hum Mol Genet. 2009 Jul 01; 18(13):2462-71. Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. PMID: 19376814; PMCID: PMC2694694.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    175. Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):956-62. Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM, Young SG. PMID: 19304573; PMCID: PMC2811263.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    176. The posttranslational processing of prelamin A and disease. Annu Rev Genomics Hum Genet. 2009; 10:153-74. Davies BS, Fong LG, Yang SH, Coffinier C, Young SG. PMID: 19453251; PMCID: PMC2846822.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    177. Caution! Analyze transcripts from conditional knockout alleles. Transgenic Res. 2009 Jun; 18(3):483-9. Yang SH, Bergo MO, Farber E, Qiao X, Fong LG, Young SG. PMID: 19093225; PMCID: PMC2679093.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    178. GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins. J Lipid Res. 2009 Apr; 50 Suppl:S57-62. Beigneux AP, Davies BS, Bensadoun A, Fong LG, Young SG. PMID: 18854402; PMCID: PMC2674691.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    179. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem. 2008 Dec 12; 283(50):34511-8. Weinstein MM, Yin L, Beigneux AP, Davies BS, Gin P, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG. PMID: 18845532; PMCID: PMC2596386.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    180. Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. J Clin Invest. 2008 Oct; 118(10):3291-300. Yang SH, Andres DA, Spielmann HP, Young SG, Fong LG. PMID: 18769635; PMCID: PMC2525700.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    181. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol. 2008 Nov; 22(11):2496-504. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. PMID: 18787041; PMCID: PMC2582544.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    182. Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res. 2009 Jan; 50(1):126-34. Davies BS, Yang SH, Farber E, Lee R, Buck SB, Andres DA, Spielmann HP, Agnew BJ, Tamanoi F, Fong LG, Young SG. PMID: 18757838; PMCID: PMC3837462.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    183. The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. J Biol Chem. 2008 Oct 24; 283(43):29554-62. Gin P, Yin L, Davies BS, Weinstein MM, Ryan RO, Bensadoun A, Fong LG, Young SG, Beigneux AP. PMID: 18713736; PMCID: PMC2662032.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    184. HIV-protease inhibitors block the enzymatic activity of purified Ste24p. Biochem Biophys Res Commun. 2008 Sep 19; 374(2):365-8. Hudon SE, Coffinier C, Michaelis S, Fong LG, Young SG, Hrycyna CA. PMID: 18639527; PMCID: PMC2543933.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    185. PCSK9 function and physiology. J Lipid Res. 2008 Jul; 49(7):1595-9. Peterson AS, Fong LG, Young SG. PMID: 18663786; PMCID: PMC3837453.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    186. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep; 49(9):2038-44. Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L. PMID: 18515909; PMCID: PMC3837456.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    187. Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease. Blood. 2008 Aug 15; 112(4):1357-65. Wahlstrom AM, Cutts BA, Liu M, Lindskog A, Karlsson C, Sjogren AK, Andersson KM, Young SG, Bergo MO. PMID: 18502828; PMCID: PMC2515151.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    188. PCSK9 function and physiology. J Lipid Res. 2008 Jun; 49(6):1152-6. Peterson AS, Fong LG, Young SG. PMID: 18375913; PMCID: PMC2386899.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    189. Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase. J Lipid Res. 2008 Jun; 49(6):1312-21. Beigneux AP, Gin P, Davies BS, Weinstein MM, Bensadoun A, Ryan RO, Fong LG, Young SG. PMID: 18340083; PMCID: PMC3055742.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    190. Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models. Curr Drug Targets. 2008 Mar; 9(3):174-89. Véniant MM, Beigneux AP, Bensadoun A, Fong LG, Young SG. PMID: 18336235; PMCID: PMC3034977.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    191. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. J Biol Chem. 2008 Apr 11; 283(15):10048-57. Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G. PMID: 18238778; PMCID: PMC2442282.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    192. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem. 2008 Apr 11; 283(15):9797-804. Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann HP, Hrycyna CA, Fong LG, Young SG. PMID: 18230615; PMCID: PMC2442292.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    193. Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele. J Biol Chem. 2008 Mar 14; 283(11):7094-9. Yang SH, Qiao X, Farber E, Chang SY, Fong LG, Young SG. PMID: 18178963.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    194. Genetic analyses of the role of RCE1 in RAS membrane association and transformation. Methods Enzymol. 2008; 438:367-89. Bergo MO, Wahlstrom AM, Fong LG, Young SG. PMID: 18413262; PMCID: PMC2386417.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    195. Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation. Biochim Biophys Acta. 2008 Jan-Feb; 1781(1-2):36-9. Yang SH, Qiao X, Fong LG, Young SG. PMID: 18082640; PMCID: PMC2266774.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    196. Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem. 2008 Jan 18; 283(3):1456-1462. Wu G, Aoyama C, Young SG, Vance DE. PMID: 18029352; PMCID: PMC3033886.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    197. Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution. Biochim Biophys Acta. 2007 Dec; 1771(12):1464-8. Gin P, Beigneux AP, Davies B, Young MF, Ryan RO, Bensadoun A, Fong LG, Young SG. PMID: 17997385; PMCID: PMC2266775.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    198. Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. Hum Mutat. 2007 Sep; 28(9):882-9. Moulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH. PMID: 17469202.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    199. ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol. 2007 Sep 18; 17(18):1561-7. Lee JA, Beigneux A, Ahmad ST, Young SG, Gao FB. PMID: 17683935.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansAnimalsCells
    200. GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons. Curr Opin Lipidol. 2007 Aug; 18(4):389-96. Young SG, Davies BS, Fong LG, Gin P, Weinstein MM, Bensadoun A, Beigneux AP. PMID: 17620854; PMCID: PMC2888298.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    201. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13432-7. Coffinier C, Hudon SE, Farber EA, Chang SY, Hrycyna CA, Young SG, Fong LG. PMID: 17652517; PMCID: PMC1948915.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    202. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS One. 2007 Jul 18; 2(7):e617. Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. PMID: 17637833; PMCID: PMC1910612.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    203. 10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins. Enzymes. 2006; 24:273-301. Young SG, Clarke SG, Bergoc MO, Phillips M, Fong LG. PMID: 26718044.
      View in: PubMed   Mentions: 3     Fields:    
    204. Cell nuclei spin in the absence of lamin b1. J Biol Chem. 2007 Jul 06; 282(27):20015-26. Ji JY, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J. PMID: 17488709.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    205. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8461-6. Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR. PMID: 17485678; PMCID: PMC1866184.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    206. GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest. 2007 May; 117(5):1294-304. Sjogren AK, Andersson KM, Liu M, Cutts BA, Karlsson C, Wahlstrom AM, Dalin M, Weinbaum C, Casey PJ, Tarkowski A, Swolin B, Young SG, Bergo MO. PMID: 17476360; PMCID: PMC1857236.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    207. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab. 2007 Apr; 5(4):279-91. Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG. PMID: 17403372; PMCID: PMC1913910.
      View in: PubMed   Mentions: 229     Fields:    Translation:AnimalsCells
    208. Mouse models of the laminopathies. Exp Cell Res. 2007 Jun 10; 313(10):2144-56. Stewart CL, Kozlov S, Fong LG, Young SG. PMID: 17493612; PMCID: PMC1949387.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    209. Prelamin A farnesylation and progeroid syndromes. J Biol Chem. 2006 Dec 29; 281(52):39741-5. Young SG, Meta M, Yang SH, Fong LG. PMID: 17090536.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    210. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation. 2006 Nov 07; 114(19):2065-9. Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD. PMID: 17075015.
      View in: PubMed   Mentions: 93     Fields:    Translation:Animals
    211. Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease. Blood. 2007 Jan 15; 109(2):763-8. Wahlstrom AM, Cutts BA, Karlsson C, Andersson KM, Liu M, Sjogren AK, Swolin B, Young SG, Bergo MO. PMID: 16973961; PMCID: PMC1785091.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    212. Protein farnesyltransferase inhibitors and progeria. Trends Mol Med. 2006 Oct; 12(10):480-7. Meta M, Yang SH, Bergo MO, Fong LG, Young SG. PMID: 16942914.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    213. Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development. 2006 Oct; 133(19):3919-28. Ishimura A, Ng JK, Taira M, Young SG, Osada S. PMID: 16943282.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    214. Inactivation of hepatic microsomal triglyceride transfer protein protects mice from diet-induced gallstones. Gastroenterology. 2006 Dec; 131(6):1870-8. Amigo L, Castro J, Miquel JF, Zanlungo S, Young S, Nervi F. PMID: 17064699.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    215. A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest. 2006 Aug; 116(8):2115-21. Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, Majumdar S, Bergo MO, Young SG, Fong LG. PMID: 16862216; PMCID: PMC1513052.
      View in: PubMed   Mentions: 140     Fields:    Translation:Animals
    216. Lamins A and C but not lamin B1 regulate nuclear mechanics. J Biol Chem. 2006 Sep 01; 281(35):25768-80. Lammerding J, Fong LG, Ji JY, Reue K, Stewart CL, Young SG, Lee RT. PMID: 16825190.
      View in: PubMed   Mentions: 336     Fields:    Translation:AnimalsCells
    217. Behavioural alterations in male mice lacking the gene for D-aspartate oxidase. Behav Brain Res. 2006 Aug 10; 171(2):295-302. Weil ZM, Huang AS, Beigneux A, Kim PM, Molliver ME, Blackshaw S, Young SG, Nelson RJ, Snyder SH. PMID: 16725213.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    218. Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues. J Lipid Res. 2006 Aug; 47(8):1733-8. Minehira-Castelli K, Leonard SW, Walker QM, Traber MG, Young SG. PMID: 16710047.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    219. Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice. Biochim Biophys Acta. 2006 Mar; 1761(3):313-23. Steenbergen R, Nanowski TS, Nelson R, Young SG, Vance JE. PMID: 16627002.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    220. D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. J Neurosci. 2006 Mar 08; 26(10):2814-9. Huang AS, Beigneux A, Weil ZM, Kim PM, Molliver ME, Blackshaw S, Nelson RJ, Young SG, Snyder SH. PMID: 16525061; PMCID: PMC6675153.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    221. A mouse monoclonal antibody specific for mouse apoB48 and apoB100 produced by immunizing "apoB39-only" mice with mouse apoB48. Biochim Biophys Acta. 2006 Feb; 1761(2):182-5. Nguyen AT, Braschi S, Geoffrion M, Fong LG, Crooke RM, Graham MJ, Young SG, Milne R. PMID: 16551509.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    222. Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest. 2006 Mar; 116(3):743-52. Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. PMID: 16511604; PMCID: PMC1386109.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    223. Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T. Infect Immun. 2006 Mar; 74(3):1712-7. Fueller F, Bergo MO, Young SG, Aktories K, Schmidt G. PMID: 16495543; PMCID: PMC1418669.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    224. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science. 2006 Mar 17; 311(5767):1621-3. Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. PMID: 16484451.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    225. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res. 2006 Apr; 47(4):734-44. Beigneux AP, Vergnes L, Qiao X, Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. PMID: 16449762; PMCID: PMC3196597.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    226. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res. 2006 Apr; 47(4):745-54. Vergnes L, Beigneux AP, Davis R, Watkins SM, Young SG, Reue K. PMID: 16436371; PMCID: PMC2901549.
      View in: PubMed   Mentions: 64     Fields:    Translation:Animals
    227. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D642-8. Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE. PMID: 16381950; PMCID: PMC1347459.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    228. Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. Methods Enzymol. 2006; 407:144-59. Svensson AW, Casey PJ, Young SG, Bergo MO. PMID: 16757321.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    229. Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem. 2006 Feb 17; 281(7):4075-86. Xie Y, Newberry EP, Young SG, Robine S, Hamilton RL, Wong JS, Luo J, Kennedy S, Davidson NO. PMID: 16354657.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    230. Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis. J Lipid Res. 2005 Dec; 46(12):2531-58. Young SG, Fong LG, Michaelis S. PMID: 16207929.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    231. Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. J Biol Chem. 2005 Dec 02; 280(48):40032-40. Steenbergen R, Nanowski TS, Beigneux A, Kulinski A, Young SG, Vance JE. PMID: 16192276; PMCID: PMC2888304.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    232. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12873-8. Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG. PMID: 16129834; PMCID: PMC1193538.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    233. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. J Biol Chem. 2005 Sep 23; 280(38):32768-74. Takahashi K, Nakagawa M, Young SG, Yamanaka S. PMID: 16046393.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    234. Transgene insertion on mouse chromosome 6 impairs function of the uterine cervix and causes failure of parturition. Biol Reprod. 2005 Nov; 73(5):1046-56. Word RA, Landrum CP, Timmons BC, Young SG, Mahendroo MS. PMID: 16034000.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    235. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10291-6. Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG. PMID: 16014412; PMCID: PMC1174929.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    236. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4336-41. Winter-Vann AM, Baron RA, Wong W, dela Cruz J, York JD, Gooden DM, Bergo MO, Young SG, Toone EJ, Casey PJ. PMID: 15784746; PMCID: PMC555472.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    237. N-myristoyltransferase 1 is essential in early mouse development. J Biol Chem. 2005 May 13; 280(19):18990-5. Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG, Peters LL, Chuang PT, Young SG, Bergo MO. PMID: 15753093.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    238. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol Biol Cell. 2005 Apr; 16(4):1606-16. Michaelson D, Ali W, Chiu VK, Bergo M, Silletti J, Wright L, Young SG, Philips M. PMID: 15659645; PMCID: PMC1073645.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    239. High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res. 2005 Apr; 46(4):769-78. Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. PMID: 15654123.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    240. Assembly of lipoprotein particles containing apolipoprotein-B: structural model for the nascent lipoprotein particle. Biophys J. 2005 Apr; 88(4):2789-800. Richardson PE, Manchekar M, Dashti N, Jones MK, Beigneux A, Young SG, Harvey SC, Segrest JP. PMID: 15653747; PMCID: PMC1305374.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    241. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18111-6. Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. PMID: 15608054; PMCID: PMC536056.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    242. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology. 2004 Oct; 127(4):1139-49. Anant S, Murmu N, Houchen CW, Mukhopadhyay D, Riehl TE, Young SG, Morrison AR, Stenson WF, Davidson NO. PMID: 15480992.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    243. The knockout mouse project. Nat Genet. 2004 Sep; 36(9):921-4. Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B. PMID: 15340423; PMCID: PMC2716027.
      View in: PubMed   Mentions: 250     Fields:    Translation:Animals
    244. Lamin B1 is required for mouse development and nuclear integrity. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10428-33. Vergnes L, Péterfy M, Bergo MO, Young SG, Reue K. PMID: 15232008; PMCID: PMC478588.
      View in: PubMed   Mentions: 196     Fields:    Translation:AnimalsCells
    245. A public gene trap resource for mouse functional genomics. Nat Genet. 2004 Jun; 36(6):543-4. Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J, International Gene Trap Consortium. PMID: 15167922; PMCID: PMC2716026.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    246. CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med. 2004 May; 10(5):535-9. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS. PMID: 15107843.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    247. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation. 2004 May 04; 109(17):2129-35. Cozen AE, Moriwaki H, Kremen M, DeYoung MB, Dichek HL, Slezicki KI, Young SG, Véniant M, Dichek DA. PMID: 15096455.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    248. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 2004 Feb; 113(4):539-50. Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG. PMID: 14966563; PMCID: PMC338259.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    249. ATP-citrate lyase deficiency in the mouse. J Biol Chem. 2004 Mar 05; 279(10):9557-64. Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG. PMID: 14662765; PMCID: PMC2888281.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    250. On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem. 2004 Feb 06; 279(6):4729-36. Bergo MO, Lieu HD, Gavino BJ, Ambroziak P, Otto JC, Casey PJ, Walker QM, Young SG. PMID: 14625273.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    251. A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation. J Cell Biol. 2003 Sep 29; 162(7):1223-32. Maske CP, Hollinshead MS, Higbee NC, Bergo MO, Young SG, Vaux DJ. PMID: 14504265; PMCID: PMC2173957.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    252. Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6529-34. Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ. PMID: 12750467; PMCID: PMC164480.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    253. Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion. Circulation. 2003 Mar 11; 107(9):1315-21. Lieu HD, Withycombe SK, Walker Q, Rong JX, Walzem RL, Wong JS, Hamilton RL, Fisher EA, Young SG. PMID: 12628954.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    254. Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER. J Lipid Res. 2003 May; 44(5):978-85. Liao W, Hui TY, Young SG, Davis RA. PMID: 12588952.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    255. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 01; 31(1):278-81. Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE. PMID: 12520002; PMCID: PMC165511.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    256. Immunochemical evidence that human apoB differs when expressed in rodent versus human cells. J Lipid Res. 2003 Mar; 44(3):547-53. Wang X, Chauhan V, Nguyen AT, Schultz J, Davignon J, Young SG, Boren J, Innerarity TL, Rutai H, Milne RW. PMID: 12562832.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    257. Hematologic effects of inactivating the Ras processing enzyme Rce1. Blood. 2003 Mar 15; 101(6):2250-2. Aiyagari AL, Taylor BR, Aurora V, Young SG, Shannon KM. PMID: 12433685.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    258. Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13049-54. Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, Van Bruggen N, Carano RA, Michaelis S, Griffey SM, Young SG. PMID: 12235369; PMCID: PMC130584.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    259. Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J Biol Chem. 2002 Oct 11; 277(41):38358-63. Beigneux A, Withycombe SK, Digits JA, Tschantz WR, Weinbaum CA, Griffey SM, Bergo M, Casey PJ, Young SG. PMID: 12151402.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    260. Extra Rabs unsnarl a lipid traffic jam. Nat Med. 2002 Jul; 8(7):662-4. Bergo MO, Young SG. PMID: 12091897.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    261. Human CYP7A1 deficiency: progress and enigmas. J Clin Invest. 2002 Jul; 110(1):29-31. Beigneux A, Hofmann AF, Young SG. PMID: 12093884; PMCID: PMC151039.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    262. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol Cell Biol. 2002 Jan; 22(1):171-81. Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, Balmain A, Young SG. PMID: 11739732; PMCID: PMC134215.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    263. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Biol Chem. 2002 Feb 15; 277(7):5476-83. Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG. PMID: 11739387.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
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