Symptoms are typically made worse by exertion of any sort. Criteria for diagnosis include a substantial reduction or impairment in ability to engage in usual activities that persists for 6 months, accompanied by new or definite onset fatigue which is not the result of excessive exertion, is not substantially alleviated by rest, and is characterized by post-exertional malaise and unrefreshing sleep. At least one of two additional manifestations is required for diagnosis: cognitive impairment and/or orthostatic intolerance.
A link to the Institute of Medicine’s ME/CFS report, is here: http://www.nationalacademies.org/hmd/Reports/2015/ME-CFS.aspx. A PDF of the report is downloadable for free at this web address: https://www.nap.edu/read/19012/chapter/1.
Investigators interested in studying potential etiologies for ME/CFS are encouraged to consider use of the Solve ME/CFS biobank, a repository of phenotypes and bio specimens contributed by individuals with this condition. Solve ME/CFS has assembled a toolkit for researchers, which includes biobank information. The toolkit is available at https://solvecfs.org/wp-content/uploads/2021/02/Toolkit-2021.pdf.
Investigators may request up $40,000 for a one year period.
The Review Committee will review letters of intent and contact investigators whom they wish to submit full pilot proposals by Monday, October 18th 2021. Funded projects will begin January 1, 2022. Criteria for selection include: (a) quality of the proposed research; (b) potential of the research to expand understanding of ME/CFS; (c) potential of the pilot funding to expand capacity for research on this topic at UCLA and affiliated sites; and (d) credentials of PI and Co-investigators (if included). Funding may be requested for any purpose which meets the needs of the investigator(s) and complies with UCLA policies for expenditure of funds. Please note that highest priority for the pilots will be given to pilots that would likely lead to R01s (or equivalent level funding from extramural sources) within 2-3 years.
Submission of Letter of Intent
The letter of intent, biosketch(s), and other attachments should be e-mailed to the attention of Kara E Justeson, KJusteson@mednet.ucla.edu; (310-794-8063). The letter of intent, biosketch(s), and other requested materials must be received by noon, Monday, October 11th, 2021. Any materials received after noon, Monday, October 11th, 2021, will not be considered.