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Top 10 Causes of Premature Death

In partnership with community groups, patient advocates and the Los Angeles Health Agency,  CTSI is advancing clinical and translational research to address the leading causes of premature death  in Los Angeles County. From 2011-2019, CTSI investigators have received a total of 182 extramural awards and authored 836 research  publications concerning the top 10 causes of premature death.

The CTSI is continuing to stimulate research to address the leading causes of premature death in Los Angeles with a particular focus on health risks that have not yet attracted wide CTSI-supported investigation, specifically drug overdose, motor vehicle accidents, suicide and violence. CTSI orchestrates the team-based collaborations among our faculty, patients, and community stakeholders to bring our collective innovations to impact health.  

Leading Causes of Premature Death in Los Angeles County, 2017

Rank Cause of Death # Extramural Awards Total Amount Awarded # Publications in Area Examples of CTSI-supported Outcomes
1 Heart Disease 59 $105M 443 A cluster-randomized trial of blood-pressure reduction in black barbershops. NEJM
2 Unintentional Drug Overdose 15 $28M 5 Physician prescribing of opioids to patients at increased risk of overdose from benzodiazepine use. JAMA Psychiatry
3 Suicide 0 0 4 At-school substance use as a marker for serious health risks. Acad Pediatrics
4 Motor Vehicle Crash 0 0 2 Traumatic brain injury related hospitalization and mortality in California. BioMed Research Intl
5 Homicide 2 $4M 5 Examination of the short-and long-term impact of school shootings. DOJ Award 2015-VF-GX-K113
6 Liver Disease /Cirrhosis 8 $15M 29 Genome-wide associations related to hepatic histology in nonalcoholic fatty liver disease in Hispanic boys. J Pediatrics
7 Diabetes 21 $39M 149 Implementation and evaluation of a large-scale teleretinal diabetic retinopathy screening program in the Los Angeles County Department of Health Services. JAMA Int Med
8 Stroke 4 $16M 70 SIRRACT: An international randomized clinical trial of activity feedback during inpatient stroke rehabilitation enabled by wireless sensing. Neurorehabilitation and Neural Repair
9 Lung Cancer 50 $75M 51 In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature
10 Breast Cancer 23 $25M 78 Modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4. Cell Reports