The Rodent Genetics Core at Cedars-Sinai provides specialized services for the production of genetically modified animals. The core offers high-quality, specific pathogen-free transgenic and knockout (knock-in) mice focused on genes of specific interest to a broad range of biomedical research projects to investigators, as well as affiliated and outside institutions. The core also helps design the DNA constructs for pronuclear microinjection or gene targeting with the most up-to-date genetic technologies such as the CRISPR/Cas9 genome editing system.

The core also offers assisted fertilization services followed by embryo transfer to save poorly breeding mutant mouse lines, as well as cryopreservation of embryos and sperm for conservation of genetic resources. The core encourages interactive usage of these animals among all CTSI-affiliated investigators. Other services include PCR genotyping, embryonic fibroblast preparation, intrabursal delivery of various substances (e.g., viral vectors, tumor cells, etc.) and blastocyst injection of ES/iPS cells.

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Last updated
February 10, 2023